A5045212323- Antibiotic Resistance in Bacteria
- Brucella: diagnosis, epidemiology, treatment
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Gout, Hyperuricemia, Uric Acid
- Burkholderia infections and melioidosis
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Receptor Mechanisms and Signaling
- Adaptive optics and wavefront sensing
- Viral gastroenteritis research and epidemiology
- Inflammasome and immune disorders
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer therapeutics and mechanisms
- Food Safety and Hygiene
- Medicinal Plants and Neuroprotection
- Ginseng Biological Effects and Applications
- Renin-Angiotensin System Studies
- Antibiotic Use and Resistance
- Animal Diversity and Health Studies
- Nosocomial Infections in ICU
- Phytochemistry and biological activities of Ficus species
- Chemical Synthesis and Analysis
Erzincan Binali Yıldırım University
2024-2025
Akdeniz University
2021-2024
Dicle University
2018
Diyarbakır Askeri Hastanesi
2011-2013
Gaziantep Children's Hospital
2011
A multiple-locus variable-number tandem-repeat analysis (MLVA) was applied to investigate the epidemiological relationship and genetic diversity among 162 human Brucella isolates collected from all geographic regions of Turkey in an 8-year period (2001 2008). The were genotyped by using MLVA assay developed Orsay, France (MLVA-16(Orsay)) including eight minisatellite (panel 1) microsatellite 2, subdivided into 2A 2B) markers. Panels 1 distinguish 14 genotypes; two these represented 85%...
The Angiotensin II type-2 receptor (AGTR2) is a G-protein coupled (GPCR) in the Renin-Angiotensin System (RAS), mediating essential roles cardiovascular regulation. Overactivation of AGTR2 causes to pathologies, ranging from hypertension cancer. Despite its physiological importance, molecular mechanisms driving activation remain poorly understood. Using long-timescale dynamics (MD) simulations, we investigated ligand binding effects (Ang II) and 1-7 1-7) on inactive active states. Our...
Multi-domain proteins, comprising both folded and intrinsically disordered regions, play pivotal roles in various biological processes, yet characterizing their conformational ensembles dynamics presents significant challenges. Here we address this challenge by introducing the Quality Evaluation Based Simulation Selection (QEBSS) protocol that enables detailed interpretation of multi-domain proteins using a combination MD simulations protein backbone 15N T1 T2 spin relaxation times hetNOE...
Abstract Multi-domain proteins, comprising both folded and intrinsically disordered regions, play pivotal roles in various biological processes, yet characterizing their conformational ensembles dynamics presents significant challenges. Here we introduce the Quality Evaluation Based Simulation Selection (QEBSS) protocol to address this challenge by systematically selecting from molecular (MD) simulation data that enable detailed interpretation of nuclear magnetic resonance (NMR) experiments....
Hyperuricemia during hypertension is associated with aberrant vascular functions and increased oxidative stress, which affects endothelial dysfunction. Nevertheless, the molecular mechanisms underlying effects of uric acid on smooth muscle cells (VSMCs) through stress remain unclear. The aim present study was to investigate dose- time-dependent p53 protein expression in VSMCs. VSMCs were incubated various concentrations (0-50 mg/dl) for different time periods (1-24 h). Thiobarbituric...
Hyperuricemia may be a risk factor for cardiovascular diseases such as hypertension and atherosclerosis, but the mechanisms underlying uric acid-induced pathological conditions remain unknown. In this study, we investigated effect of short time long-term administration increasing acid concentrations on cell viability, proliferative apoptotic pathways in vascular smooth muscle cells (VSMCs). Cell viability/proliferation was determined with WST-1 assay. Expression levels mitogen-activated...
Background: Brucellosis is a zoonotic disease caused by Brucella species. Although brucellosis considered as an occupational in adults, recently it has become infectious affecting all age groups, including children. Molecular epidemiological studies are crucial for control and treatment of Objectives: This study aimed at identifying species, to detect antibiotic susceptibilities define transmission dynamics between the isolates Methods: A total 77 were identified conventional polymerase...
Objective: We report two foodborne outbreaks caused by Salmonella enterica serovar Enteritidis occurred in four youth hostels and private schools Diyarbakir, Turkey to identify the involving pathogen(s) possible source of infection, control prevent further outbreaks. Material Methods: An outbreak survey was conducted food items, water supply, work surface samples stool cultures were analyzed. Results: Out 346 persons, a questionnaire administered 208 117 affected ill 91 healthy describe...
Possible allosteric inhibitors of MPro were investigated using in silico methods. To this end, FDA-approved drugs the DrugBank database subjected to virtual screening, and that strongly bind distant from catalytic site identified molecular docking. Among drugs, Dihydroergotamine (DHE) was chosen for further investigation due its highest binding score against docking experiment. The inhibition potential DHE toward demonstrated by applying some computational tools on trajectory files which...
The understanding of the connections between Angiotensin peptides with receptors in Renin-angiotensin system (RAS) is not clear yet. ACE2/Ang (1-7)/MAS axis, commonly referred to as protective arm RAS, plays a crucial role maintaining homeostasis within cardiovascular system. 1-7 (Ang 1-7) heptapeptide an integral part RAS and acts ligand binding MAS receptor. Understanding signaling which occupies important place can be considered serious putative target for development new cancer drugs. It...