A5058634658- Dermatology and Skin Diseases
- Hair Growth and Disorders
- Lipoproteins and Cardiovascular Health
- Immune Cell Function and Interaction
- Osteoarthritis Treatment and Mechanisms
- Drug Transport and Resistance Mechanisms
- Drug Solubulity and Delivery Systems
- Cancer, Lipids, and Metabolism
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Skin Protection and Aging
- Bone health and treatments
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
Mokpo National University
2022-2023
To prepare a topical formulation of bimatoprost (BIM) with high skin permeability, we designed solvent mixture system composed ethanol, diethylene glycol monoethyl ether, cyclomethicone, and butylated hydroxyanisole, serving as volatile solvent, nonvolatile co-solvent, spreading agent, antioxidant, respectively. The ideal BIM (BIM-TF#5) exhibited 4.60-fold higher human flux 529% increase in dermal drug deposition compared to ethanol. In addition, the other formulations, BIM-TF#5 maximally...
Atorvastatin (ATV) has attracted considerable attention as a potential therapeutic agent for cancer because it inhibits cell proliferation by suppressing the mevalonate pathway. However, of its low oral absorption, high doses ATV are required chemotherapeutic applications. In this study, we constructed ATV-loaded nanoemulsions (ATV-NEs) containing multivalent intestinal transporter-targeting lipids to improve bioavailability ATV. ATV-NEs were prepared via oil-in-water emulsification...
Atraric acid (AA) is a phenolic compound isolated from Stereocaulon japonicum that has demonstrated anti-androgen properties and was used to design an alternative formulation for the treatment of alopecia. This new topical designed using solvent mixture system composed ethanol as volatile vehicle, oleic permeation enhancer, water skin hydration. The ideal AA (AA-TF#15) exhibited 8.77-fold higher human flux 570% increase in dermal drug deposition, compared 1% (w/w) ethanol. In addition, other...