A5082718095- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Dermatology and Skin Diseases
- Phytochemicals and Antioxidant Activities
- Hair Growth and Disorders
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
- Drug Solubulity and Delivery Systems
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Natural Antidiabetic Agents Studies
- Nanoparticle-Based Drug Delivery
- Skin Protection and Aging
- Medicinal Plants and Neuroprotection
- Mesenchymal stem cell research
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Phytochemicals and Medicinal Plants
- Belt Conveyor Systems Engineering
- Nail Diseases and Treatments
- Lipoproteins and Cardiovascular Health
- Osteoarthritis Treatment and Mechanisms
Mokpo National University
2020-2025
Pokhara University
2025
Toronto Metropolitan University
2021-2024
Tribhuvan University
2016-2023
Merrill (United States)
2015
Background Crateva unilocularis, Millettia extensa, and Plumbago zeylanica are commonly used traditional medicinal plants in Nepal for treating various skin ailments. Objectives The ethanol extracts of these were analyzed qualitative quantitative phytochemical content, antioxidant potential, anti-tyrosinase activity. Methods Folin-Ciocalteu technique was to measure the total phenolic aluminum chloride method assess flavonoid content.In vitro activity evaluated via 2,2-...
To prepare a topical formulation of bimatoprost (BIM) with high skin permeability, we designed solvent mixture system composed ethanol, diethylene glycol monoethyl ether, cyclomethicone, and butylated hydroxyanisole, serving as volatile solvent, nonvolatile co-solvent, spreading agent, antioxidant, respectively. The ideal BIM (BIM-TF#5) exhibited 4.60-fold higher human flux 529% increase in dermal drug deposition compared to ethanol. In addition, the other formulations, BIM-TF#5 maximally...
In this study, a system for oral delivery of etoposide (ETP) was designed to avoid the problems associated with low and variable bioavailability commercially available ETP emulsion comprised polyethylene glycol, glycerol, citric acid anhydrous. complexed low-molecular-weight methylcellulose (ETP/LMC) loaded into water-in-oil-in-water multiple nanoemulsion formulate an ETP/LMC-nanoemulsion (ELNE). To further enhance bioavailability, ionic complex formed by anionic lipid...
The anticancer efficacy of orally administered chemotherapeutics is often constrained by low intestinal membrane permeability and oral bioavailability. In this context, we designed a solid formulation oxaliplatin (OP), third-generation cisplatin analog, to improve bioavailability investigate its application in metronomic chemotherapy.An ion-pairing complex OP with permeation enhancer, Nα-deoxycholyl-l-lysyl-methylester (DLM), was successfully prepared then mixed dispersing agents (including...
In this study, a stable and highly skin-permeable topical delivery system for itraconazole (ITZ) was designed to provide effective treatment against superficial mycosis. Herein, ITZ incorporated into solution composed of ethanol, benzyl alcohol, hydrochloric acid, Transcutol P, cyclomethicone as vehicle, solubilizer, protonating agent, permeation enhancer, spreading respectively. At 72 h, the optimal formulation (ITZ–TF#11) exhibited 135% enhanced skin permeability, which led increases in...
In this study, we developed oral pemetrexed (PMX) for metronomic dosing to enhance antitumor immunity. PMX was electrostatically complexed with positively charged lysine-linked deoxycholic acid (DL) as an intestinal permeation enhancer, forming PMX/DL, its permeability. PMX/DL also incorporated into a colloidal dispersion (CD) comprised of the block copolymer poly(ethylene oxide) and poly(propylene oxide), caprylocaproyl macrogol-8 glycerides (PMX/DL-CD). CD-containing complex in 1:1 molar...
Atorvastatin (ATV) has attracted considerable attention as a potential therapeutic agent for cancer because it inhibits cell proliferation by suppressing the mevalonate pathway. However, of its low oral absorption, high doses ATV are required chemotherapeutic applications. In this study, we constructed ATV-loaded nanoemulsions (ATV-NEs) containing multivalent intestinal transporter-targeting lipids to improve bioavailability ATV. ATV-NEs were prepared via oil-in-water emulsification...
Atraric acid (AA) is a phenolic compound isolated from Stereocaulon japonicum that has demonstrated anti-androgen properties and was used to design an alternative formulation for the treatment of alopecia. This new topical designed using solvent mixture system composed ethanol as volatile vehicle, oleic permeation enhancer, water skin hydration. The ideal AA (AA-TF#15) exhibited 8.77-fold higher human flux 570% increase in dermal drug deposition, compared 1% (w/w) ethanol. In addition, other...
Abstract Background Despite the effectiveness of glucagon-like peptide-1 agonist (GLP-1A) in treatment diabetes, its large molecular weight and high hydrophilicity result poor cellular permeability, thus limiting oral bioavailability. To address this, we developed a chimeric GLP-1A that targets transporter-mediated endocytosis to enhance permeability by utilizing transporters available intestine, particularly apical sodium-dependent bile acid transporter (ASBT). Methods In silico docking...
Type 2 diabetes is a chronic disease characterized by insulin resistance and often worsened obesity. Effective management involves the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to assist with glycemic control weight management. However, these drugs must be administered subcutaneously due their low oral bioavailability. We developed an liraglutide (LRG) formulation electrostatic complexation GLP-1 RA bile acid derivatives nanomicelle (NM) formation, non-ionic surfactant...
Utilities typically depend on customers to call and inform them of the service interruptions due outages by entering their addresses. After sufficient calls are received, utility is able pinpoint location outages. It essential for have a good idea before sending crew restoration work optimally utilize resources. This article uses an idiotypic immune system model simulate radial distribution identify operated protective devices The incoming modeled as antigens, antibodies. Using differential...
Lithological and microstructural study carried out in Bhainse –Manahari area, central Nepal reveals that the rock sequences of Bhainse–Manahari area can be divided into two successions: Nawakot Complex Kathmandu Complex. These Complexes are separated by a distinct thrust boundary, Mahabharat Thrust (MT). The consists low-grade metamorphic rocks like slate, phyllite, quartzite limestone while comprises medium grade (up to garnet grade) garnet-schist, marble mica-schist. (MT) Manahari (MnT)...
Diabetes mellitus, a physiological disorder is characterized by low secretion of insulin due to the attack in producing beta cell (Type I) or body become resistance II). This study was designed evaluate DPPH lowering effect, in-vitro alpha amylase and glucose diffusion inhibition selected medicinal plants. Five different plant sample Amomum subulatum, Choerospondias axillaris, Musa sp, Myrica esculenta Nephrolepis cordifolia were taken for study. From result it revealed that methanol...
<p>The acoustic mechanism of ultrasound- Microbubble (MB) mediated sonoporation enhanced permeability cell membranes has been associated with inertial and stable cavitations. The main objective this study was to characterise behaviour MB, under varying pressure pulse duration using passive cavitation detection(PCD) technique. MBs were exposed 1 MHz ultrasound at (0-1.5 MPa), (5-30μs) repetition frequency KHz for insonation time second. phenomena detected passively two transducers...
Acoustic Characteristics Of Microbubbles: Effect Pressure And Pulse Duration
<p>The acoustic mechanism of ultrasound- Microbubble (MB) mediated sonoporation enhanced permeability cell membranes has been associated with inertial and stable cavitations. The main objective this study was to characterise behaviour MB, under varying pressure pulse duration using passive cavitation detection(PCD) technique. MBs were exposed 1 MHz ultrasound at (0-1.5 MPa), (5-30μs) repetition frequency KHz for insonation time second. phenomena detected passively two transducers...