A5088634786- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Lymphatic System and Diseases
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Gut microbiota and health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Research and Treatments
- Clusterin in disease pathology
- Cellular Mechanics and Interactions
Quadram Institute
2019-2024
Norwich Research Park
2019-2024
University of East Anglia
2024
Angiogenesis relies on the ability of endothelial cells (ECs) to migrate over extracellular matrix via integrin receptors respond an angiogenic stimulus. Of two neuropilin (NRP) orthologs be identified, both have been reported expressed normal blood and lymphatic ECs, play roles in formation vascular networks during angiogenesis. Whilst role NRP1 its interactions with integrins angiogenesis has widely studied, NRP2 ECs is poorly understood. Here we demonstrate that promotes Rac-1 mediated EC...
The ability to form a variety of cell-matrix connections is crucial for angiogenesis take place. Without stable anchorage the extracellular matrix (ECM), endothelial cells (ECs) are unable sense, integrate and disseminate growth factor stimulated responses that drive vascular bed. Neuropilin-2 (NRP2) widely expressed membrane-bound multifunctional non-tyrosine kinase receptor, which has previously been implicated in influencing cell adhesion migration by interacting with α5-integrin...
The mechanosensing properties of endothelial cell-cell junctions are essential for vascular beds to respond the mechanical forces exerted by blood flow. In states disturbed flow, cells (ECs) become activated and transition a pro-inflammatory, atheroprone phenotype. Here, we investigated role transmembrane glycoprotein neuropilin 2 (NRP2) in maintaining adherens junction integrity using cultured immortalised mouse ECs genetically modified model demonstrate effects an endothelial-specific...
Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles facilitating tumorigenesis by promoting invasive vessel growth. Despite this, it remains unclear as whether NRP1 and NRP2 act a synergistic manner enhance pathologic angiogenesis. Here we demonstrate, using NRP1ECKO, NRP2ECKO, NRP1/NRP2ECKO mouse models, that maximum inhibition...
Abstract Integrin trafficking to and from membrane adhesions is a crucial mechanism that dictates many aspects of cell’s behaviour, including motility, polarisation, invasion. In endothelial cells (ECs), the intracellular traffic α5 integrin regulated by both neuropilin 1 (NRP1) 2 (NRP2), yet redundancies in function between these co-receptors remain unclear. Moreover, endocytic complexes participate NRP-directed poorly annotated. Here we identify an important role for GTPase-activating...
<title>Abstract</title> Integrin trafficking to/from membrane adhesions is a crucial mechanism that dictates many aspects of cell’s behaviour, including motility, polarisation, and invasion. In endothelial cells (ECs), the intracellular traffic α5-integrin regulated by both neuropilin-1 (NRP1) neuropilin-2 (NRP2), yet redundancies in function between these co-receptors remain unclear. Moreover, endocytic complexes participate NRP-directed poorly annotated. Using comprarative label-free...
Gut microbes have merged as powerful regulators of cancer responses, with Bifidobacterium species and strains playing a key role in promoting anti-tumour immunity. While they represent promising candidates for therapeutics, the specific underlying microbial mechanisms driving their efficacy remains poorly understood. In this study, we demonstrate broad potential to inhibit breast progression across multiple pre-clinical mouse models. We identify novel strain, pseudocatenulatum 210, which...
Abstract Angiogenesis relies on the ability of endothelial cells (ECs) to migrate over extracellular matrix via integrin receptors respond an angiogenic stimulus. Of two neuropilin (NRP) orthologs be identified, both have been reported expressed normal blood and lymphatic ECs, play roles in formation vascular networks during angiogenesis. Whilst role NRP1 its interactions with integrins angiogenesis has widely studied, NRP2 ECs is poorly understood. Here we demonstrate that promotes Rac-1...
<div><p>Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles facilitating tumorigenesis by promoting invasive vessel growth. Despite this, it remains unclear as whether NRP1 and NRP2 act a synergistic manner enhance pathologic angiogenesis. Here we demonstrate, using NRP1<i><sup>ECKO</sup></i>,...
<div><p>Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles facilitating tumorigenesis by promoting invasive vessel growth. Despite this, it remains unclear as whether NRP1 and NRP2 act a synergistic manner enhance pathologic angiogenesis. Here we demonstrate, using NRP1<i><sup>ECKO</sup></i>,...
<p>NRP co-depletion promotes VEGF receptor degradation</p>
<p>Angiogenesis is inhibited in PyMT-BO1 tumours upon NRP1 and NRP2 depletion</p>
<p>Co-targeting NRP1 and NRP2 inhibits tumour growth angiogenesis</p>
<p>NRP co-depletion promotes VEGF receptor degradation</p>
<p>Angiogenesis is inhibited in PyMT-BO1 tumours upon NRP1 and NRP2 depletion</p>
<p>Co-targeting NRP1 and NRP2 inhibits tumour growth angiogenesis</p>
Abstract The ability to form a variety of cell-matrix connections is crucial for angiogenesis take place. Without stable anchorage the extracellular matrix (ECM), endothelial cells (ECs) are unable sense, integrate and disseminate growth factor stimulated responses that drive vascular bed. Neuropilin-2 (NRP2) widely expressed membrane-bound multifunctional non-tyrosine kinase receptor, has previously been implicated in influencing cell adhesion migration by interacting with α5-integrin...