A5035222381- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Cell Adhesion Molecules Research
- Lymphatic System and Diseases
- Cellular Mechanics and Interactions
- Monoclonal and Polyclonal Antibodies Research
Quadram Institute
2021-2024
Norwich Research Park
2021-2024
The ability to form a variety of cell-matrix connections is crucial for angiogenesis take place. Without stable anchorage the extracellular matrix (ECM), endothelial cells (ECs) are unable sense, integrate and disseminate growth factor stimulated responses that drive vascular bed. Neuropilin-2 (NRP2) widely expressed membrane-bound multifunctional non-tyrosine kinase receptor, which has previously been implicated in influencing cell adhesion migration by interacting with α5-integrin...
Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles facilitating tumorigenesis by promoting invasive vessel growth. Despite this, it remains unclear as whether NRP1 and NRP2 act a synergistic manner enhance pathologic angiogenesis. Here we demonstrate, using NRP1ECKO, NRP2ECKO, NRP1/NRP2ECKO mouse models, that maximum inhibition...
Abstract Integrin trafficking to and from membrane adhesions is a crucial mechanism that dictates many aspects of cell’s behaviour, including motility, polarisation, invasion. In endothelial cells (ECs), the intracellular traffic α5 integrin regulated by both neuropilin 1 (NRP1) 2 (NRP2), yet redundancies in function between these co-receptors remain unclear. Moreover, endocytic complexes participate NRP-directed poorly annotated. Here we identify an important role for GTPase-activating...
<div><p>Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles facilitating tumorigenesis by promoting invasive vessel growth. Despite this, it remains unclear as whether NRP1 and NRP2 act a synergistic manner enhance pathologic angiogenesis. Here we demonstrate, using NRP1<i><sup>ECKO</sup></i>,...
<div><p>Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles facilitating tumorigenesis by promoting invasive vessel growth. Despite this, it remains unclear as whether NRP1 and NRP2 act a synergistic manner enhance pathologic angiogenesis. Here we demonstrate, using NRP1<i><sup>ECKO</sup></i>,...
<p>NRP co-depletion promotes VEGF receptor degradation</p>
<p>Angiogenesis is inhibited in PyMT-BO1 tumours upon NRP1 and NRP2 depletion</p>
<p>Co-targeting NRP1 and NRP2 inhibits tumour growth angiogenesis</p>
<p>NRP co-depletion promotes VEGF receptor degradation</p>
<p>Angiogenesis is inhibited in PyMT-BO1 tumours upon NRP1 and NRP2 depletion</p>
<p>Co-targeting NRP1 and NRP2 inhibits tumour growth angiogenesis</p>
Abstract The ability to form a variety of cell-matrix connections is crucial for angiogenesis take place. Without stable anchorage the extracellular matrix (ECM), endothelial cells (ECs) are unable sense, integrate and disseminate growth factor stimulated responses that drive vascular bed. Neuropilin-2 (NRP2) widely expressed membrane-bound multifunctional non-tyrosine kinase receptor, has previously been implicated in influencing cell adhesion migration by interacting with α5-integrin...