A5039989318- Chemotherapy-induced cardiotoxicity and mitigation
- Electron Spin Resonance Studies
- Cancer Immunotherapy and Biomarkers
- Ion channel regulation and function
- Takotsubo Cardiomyopathy and Associated Phenomena
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Memory and Neural Mechanisms
- Pericarditis and Cardiac Tamponade
- Cancer Treatment and Pharmacology
- Pharmacological Receptor Mechanisms and Effects
- Atrial Fibrillation Management and Outcomes
- Sirtuins and Resveratrol in Medicine
- Carbon Nanotubes in Composites
- Respiratory Support and Mechanisms
- Analytical Chemistry and Sensors
- Polymer Nanocomposite Synthesis and Irradiation
- Non-Invasive Vital Sign Monitoring
- Neuroendocrine regulation and behavior
- Breast Lesions and Carcinomas
- CAR-T cell therapy research
- Cardiac Arrhythmias and Treatments
- Brain Metastases and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
Fourth Hospital of Hebei Medical University
2015-2024
Hebei Medical University
2015-2024
Abstract Background Over the past decade, immune checkpoint inhibitors (ICIs) have significantly transformed cancer treatment. However, ICIs inevitably may cause a spectrum of immune‐related adverse events, among which cardiovascular toxicity, particularly myocarditis, while infrequent, has garnered increasing attention due to its high fatality rate. Methods We conducted multicenter retrospective study characterize ICI‐associated events. Logistic regression was performed explore risk factors...
Abstract Histone modifications have been implicated in learning and memory. Our previous transcriptome data showed that expression of sirtuins 6 (SIRT6), a member deacetylases (HDACs) family the hippocampal cornu ammonis 1 (CA1) was decreased after contextual fear conditioning. However, role SIRT6 formation memory is still elusive. In present study, we found conditioning inhibited translational CA1. Microinfusion lentiviral vector-expressing into theCA1 region selectively enhanced impaired...
Abstract Drug addiction is considered an aberrant form of learning and drug-associated memories evoked by the presence associated stimuli (drug context or drug-related cues) contribute to recurrent craving reinstatement. Epigenetic changes mediated DNA methyltransferase (DNMT) have been implicated in reconsolidation fear memory. Here, we investigated role DNMT activity cocaine-associated memories. Rats were trained over 10 days intravenously self-administer cocaine nosepokes. Each injection...
Introduction. Patients receiving chemotherapy for breast cancer may be at risk of developing cardiac dysfunction and electrophysiological abnormalities. The aim this study is to evaluate alterations in electrocardiographic (ECG) parameters patients chemotherapy. Materials Methods. This was a prospective single-center cohort conducted the Fourth Hospital Hebei Medical University, China. Participants with referred from May 1, 2019, October were invited participate study. Standard 12-lead ECG...
Abstract Background The risk of arrhythmia is usually assessed by the length corrected QT interval (QTc) when patients use antipsychotics. Prolonged QTc intervals are thought to increase probability malignant ventricular arrhythmias, and if we focus only on interval, may be influenced a single factor make decisions that not conducive effective treatment. index cardiac electrophysiological balance (iCEB) considered more valuable than for predicting drug-induced arrhythmias. It has been used...
Wellens syndrome is a comprehensive electrocardiographic (ECG) diagnosis that combines medical history with characteristic ECG changes. These changes, characterized by biphasic T-wave inversions or symmetric and deep in the anterior precordial leads, often indicate left descending coronary artery at high risk of severe stenosis. Chemotherapy-related cardiovascular toxicity refers to damage system caused chemotherapeutic drugs, which unpredictable may occur during after chemotherapy.
To evaluate the incidence of arrhythmias and electrocardiographic (ECG) characteristics in cancer patients treated with immune checkpoint inhibitors (ICIs).
This case report describes a patient in their early 70s with sudden onset squeezing precordial chest pain, back and nausea, history of long-term lung cancer treatment.
Objective To explore the reference values of impulse oscillometry system (IOS) for healthy adults in Hebei district. Methods To survey pulmonary function by a 409 different occupations, which were accordance with requirements determination European respiratory society.Observation parameters included impedance (Zrs), breathing resistance R5, R20 (kPa·L-1·s-1) 5 Hz、20 Hz, reactance (X5)、the center (Rc)、peripheral (Rp), response elastic was equal to inertial frequency (Fres), R5、R20...
This case report describes a woman in her 20s who had 1-day history of palpitations and dyspnea. Her medical was significant for breast cancer.
<title>Abstract</title> <bold>Objective </bold>Antipsychotics can prolong the time of ventricular repolarization. Multiple-drug interactions may increase risk developing cardiac arrhythmias. It is generally recommended to avoid combination drugs that repolarization or interact with pharmacokinetics, but in real world,the inevitable. We retrospectively analyzed heart rate, QRS duration, QT, QTc, TpTe, TpTe / QRS, QTc consecutive patients schizophrenia, electrophysiological balance index...
本文报道1例男性患者，62岁。入院诊断为心房扑动，高血压3级。行心房扑动射频消融术后19 h，动态心电图记录到罕见的房室结三径路现象。本例慢-快型房室结折返性心动过速折返环较长，心室率较慢，消融后期随访尚未发生心悸及突发性心率增快等现象。.
Abstract Funding Acknowledgements Type of funding sources: None. Background Patients receiving chemotherapy for breast cancer (BC) may develop cardiac electrophysiological abnormalities. The aim this study is to examined possible alterations in parameters detected by three-dimensional vectorcardiograms (3D-VCGs) BC patients who received chemotherapy. Methods This was a prospective single-center cohort conducted. with referred from May 1, 2019, October 2019 were invited participate the study....