A5100784406- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Gut microbiota and health
- Effects and risks of endocrine disrupting chemicals
- Circadian rhythm and melatonin
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Toxin Mechanisms and Immunotoxins
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Bone Metabolism and Diseases
- Toxic Organic Pollutants Impact
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Environmental Quality and Pollution
- Epigenetics and DNA Methylation
- Atherosclerosis and Cardiovascular Diseases
- Memory and Neural Mechanisms
- Protease and Inhibitor Mechanisms
- Receptor Mechanisms and Signaling
- Water Quality Monitoring and Analysis
- Eicosanoids and Hypertension Pharmacology
- Technology and Human Factors in Education and Health
- Genetics and Neurodevelopmental Disorders
Hebei Medical University
2011-2025
Hebei Chemical and Pharmaceutical College
2020-2021
Peking Union Medical College Hospital
2014
Chinese Academy of Medical Sciences & Peking Union Medical College
2014
Zhejiang A & F University
2013
East China Normal University
2011
Tourette syndrome (TS) is a common chronic neuropsychiatric disorder with prevalence of approximately 1% in children and adolescents. TS characterized by sudden involuntary motor tics along vocal tics. A pathological study on postmortem patients has reported 50-60% reduction striatal gamma-aminobutyric acidergic (GABAergic) interneurons, suggesting role for GABAergic system imbalances tic development. However, the effect exogenous GABA administration alleviation remains unreported. In this...
Smooth muscle cell marker, SM22α, was down-regulated in the pathogenesis of arterial diseases including atherosclerosis, restenosis and abdominal aortic aneurysms. However, question still exists whether this down-regulation actively contributes to vascular diseases. In an ongoing effort understand role here we explored transcriptome profiling by RNA-Seq from arteries SM22α(-/-) SM22α(+/+) mice. Analysis revealed that most enriched pathways caused SM22α-knockout were hematopoiesis,...
Abstract Histone modifications have been implicated in learning and memory. Our previous transcriptome data showed that expression of sirtuins 6 (SIRT6), a member deacetylases (HDACs) family the hippocampal cornu ammonis 1 (CA1) was decreased after contextual fear conditioning. However, role SIRT6 formation memory is still elusive. In present study, we found conditioning inhibited translational CA1. Microinfusion lentiviral vector-expressing into theCA1 region selectively enhanced impaired...
Depression is a global health problem, and there pressing need for better understanding of its pathogenesis. Semaphorin 3B (Sema 3B) an important axon guidance molecule that primarily expressed in neurons contributes to synaptic plasticity. Our previous studies using high-throughput microarray assay suggested Sema expression was tremendously decreased during the development depression, but specific role mechanisms depression are still unknown. Herein, we report levels protein hippocampus...
BackgroundPostweaning is a pivotal period for brain development and individual growth. As an important chemical used in medicines, foods beverages, sodium citrate (SC) commonly available. Although some effects of SC exposure on physiology have been demonstrated, the potential long-lasting postweaning dietary supplementation social behaviours are still elusive.MethodsBoth male female C57BL/6 mice were exposed to through drinking water total 3 weeks. A series behavioural tests, including...
Background The pathogenesis of depression is closely related to changes in hippocampal synaptic plasticity; however, the underlying mechanism still unclear. Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2), a postsynaptic scaffold excitatory synapses important for plasticity, highly expressed hippocampus and has been implicated several psychiatric disorders. However, role BAIAP2 remains poorly understood. Methods In present study, mouse model was established via exposure...
Background: Gut microbiota and its metabolites can influence brain function related behaviors. Trimethylamine N-oxide (TMAO), an indirect metabolite of gut microbiota, has been linked to aging, cognitive impairment, many disorders, but potential effects on socioemotional behaviors remain elusive. Methods: The present study investigated the early life systemic TMAO exposure intra-hippocampal infusion during adulthood in mice. Hippocampal metabolomics analysis was performed explore mechanisms....