A5101739050- Higher Education and Teaching Methods
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Hearing Impairment and Communication
- NF-κB Signaling Pathways
- Education and Work Dynamics
- Circular RNAs in diseases
- Educational Technology and Assessment
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Natural product bioactivities and synthesis
- Angiogenesis and VEGF in Cancer
- Bone and Dental Protein Studies
- Sesquiterpenes and Asteraceae Studies
- S100 Proteins and Annexins
- Ideological and Political Education
- Plant Toxicity and Pharmacological Properties
- Biological Stains and Phytochemicals
- Caveolin-1 and cellular processes
- Phytochemistry and Biological Activities
- China's Ethnic Minorities and Relations
University of Kansas Medical Center
2024
Hebei Medical University
2009-2021
Tumor Hospital of Xinjiang Medical University
2020
Xinjiang Medical University
2020
State Key Laboratory of Genetic Engineering
2015
Fudan University
2015
Hunan Normal University
2014
Tianjin University of Technology
2013
Changchun Normal University
2007-2012
Peking University
2007-2012
Vascular smooth muscle cells (VSMCs) can switch between differentiated and dedifferentiated phenotypes, this phenotype is believed to be essential for repair of vascular injury. We studied the inhibitory effect 22 alpha (SM22 alpha) on VSMC proliferation in vitro vivo explored potential molecular mechanisms effect.By using coimmunoprecipitation glutathione S-transferase pull-down assays, we have shown that SM22 binds Ras alpha-overexpressed VSMCs presence or absence platelet-derived growth...
Previously, our group and others have demonstrated a causative relationship between severe hypertriglyceridaemia atherogenesis in mice. Furthermore, clinical investigations shown high levels of plasma Apolipoprotein C-III (ApoCIII) associated with even cardiovascular disease. However, it remains unclear whether ApoCIII affects restenosis vivo, such an effect is mediated by alone, or combination hypertriglyceridaemia. We sought to investigate clarify how smooth muscle cells (SMCs) respond...
The role of Eps8 in human breast cancer was studied, and we found that overexpressed >60% samples compared with adjacent normal tissues by immunohistochemical analysis. highly expressed the invasive cell line MDA-MB‑231 weakly lines MCF7 MDA-MB‑468. stably expressing established G418 screening, ectopic expression enhanced growth survival as assessed MTT analysis, viability liquid colony formation, whereas lentiviral shRNA cells resulted a significant reduction cellular proliferation vitro...
Knowledge of the leaf anatomy grassland plants is crucial for understanding how these adapt to environment. Tibetan alpine grasslands and Inner Mongolian temperate are two major types in northern China. occur high-altitude regions where low temperatures limit plant growth. found arid moisture limiting factor. Few comparative studies concerning Plateau have been conducted. We examined characteristics at 71 sites among 65 species, across Plateau. compared structures with different life forms...
Sirtuin 1 (SIRT1) inhibits nuclear factor kappa B (NF-κB) activity in response to the inflammatory cytokine tumour necrosis alpha (TNF-α). Smooth muscle (SM) 22α is a phosphorylation-regulated suppressor of IKK-IκBα-NF-κB signalling cascades vascular smooth cells (VSMCs). Sm22α knockout results increased expression pro-inflammatory genes aortas which are controlled by NF-κB. This study aimed investigate relationship between SM22α and SIRT1 control inflammation.The ligation injury model...
Objective— Smooth muscle (SM) 22α, an actin-binding protein, displays upregulated expression as a marker during cellular senescence. However, the causal relationship between SM22α and senescence is poorly understood. This study aimed to investigate role of in angiotensin II (Ang II)–induced vascular smooth cells (VSMCs). Approach Results— We prepared model VSMC induced by Ang found that VSMCs was increased response chronic treatment. Overexpression promoted II–induced senescence, whereas...
Smooth muscle (SM) 22α, an actin-binding protein, is down-regulated in atherosclerotic arteries. Disruption of SM22α promotes arterial inflammation through activation reactive oxygen species (ROS)-mediated nuclear factor (NF)-κB pathways. This study aimed to investigate the mechanisms by which regulates vascular inflammatory response. The ligation injury model SM22α(-/-) mice displayed up-regulation molecules MCP-1, VCAM-1, and ICAM-1 carotid Similar results were discovered human samples. In...
We previously demonstrated that smooth muscle (SM) 22α promotes the migration activity in contractile vascular cells (VSMCs). Based on varied functions exhibited by SM22α different VSMC phenotypes, we investigated effect of under pathological conditions. The results overexpression synthetic VSMCs inhibited platelet-derived growth factor (PDGF)-BB-induced cell lamellipodium formation and migration, which was from its action cells. indicated two distinct mechanisms underlying inhibition SM22α,...
Smooth muscle cell marker, SM22α, was down-regulated in the pathogenesis of arterial diseases including atherosclerosis, restenosis and abdominal aortic aneurysms. However, question still exists whether this down-regulation actively contributes to vascular diseases. In an ongoing effort understand role here we explored transcriptome profiling by RNA-Seq from arteries SM22α(-/-) SM22α(+/+) mice. Analysis revealed that most enriched pathways caused SM22α-knockout were hematopoiesis,...
The binding sequences for signal transducer and activator of transcription (STAT) protein 1 have been found in the promoter region angiotensinogen gene. We examined whether elements STAT5B function gene activation induced by angiotensin II vascular smooth muscle cells. Stimulation with increased level mRNA 2.1‐fold occurred concurrent elevations levels c‐Jun phosphorylation after stimulation II. Likewise, resulted similar enhancements DNA‐binding activity II‐induced expression. Notably,...
<b>Objective:</b> To investigate the expression level of miR-142-5p and its potential target gene endothelial PAS domain protein 1(EPAS1) in Stage III colorectal cancer during Transcatheter arterial infusion chemotherapy (TAI). <b>Materials Methods:</b> Illumina high-throughput sequencing was used to obtain miRNA profiles paired tumor adjacent normal tissues from one patient received TAI 1 week before operation another directly underwent an operation. The levels measured with both...
Tumor vessels often lack the smooth muscle layer, and instability is conducive to tumor invasion metastasis. The effect of microenvironment on vascular cells needs be explored. In present study, we examined density in human colorectal cancer tissues, used conditioned medium HT29 mimic microenvironment. We showed that vessel tissues increased, which displayed a decreased expression α-actin, specific marker an attenuated or discontinuous layer compared with matched normal tissues. also cell...
Abstract Background: Liquid biopsy offers a non-invasive method for detection of non-Hodgkin lymphoma (NHL). Tissue biopsy, the standard NHL detection, causes patient discomfort and increases risk infection. Extracellular vesicles (EVs) are secreted by cells as particles with cargos nucleic acids proteins enclosed in lipid bilayer. The most common subtype is diffuse large B-cell (DLBCL). We analyzed plasma-derived EVs from DLBCL patients matching healthy controls microRNA (miRNA) protein to...