A5090002147- Parasitic Infections and Diagnostics
- Genomics and Phylogenetic Studies
- Biochemical and Structural Characterization
- Insect symbiosis and bacterial influences
- Transgenic Plants and Applications
- Microbial Natural Products and Biosynthesis
- Bartonella species infections research
- Bacteriophages and microbial interactions
- Vector-borne infectious diseases
- Marine Sponges and Natural Products
- Protist diversity and phylogeny
- Carbohydrate Chemistry and Synthesis
- Viral Infections and Vectors
- Microbial infections and disease research
- Chemical synthesis and alkaloids
- Plant and fungal interactions
- Plant and Fungal Interactions Research
- Research on Leishmaniasis Studies
- Phytochemical compounds biological activities
- Helminth infection and control
- Reproductive tract infections research
- Clostridium difficile and Clostridium perfringens research
- RNA and protein synthesis mechanisms
- Amoebic Infections and Treatments
- Parasites and Host Interactions
Uppsala University
2002-2018
Swedish Veterinary Agency
2014-2018
Newcastle University
2013
Uppsala University Hospital
2004
We present the complete genomes of two human pathogens, Bartonella quintana (1,581,384 bp) and henselae (1,931,047 bp). The pathogens maintain several similarities in being transmitted by insect vectors, using mammalian reservoirs, infecting similar cell types (endothelial cells erythrocytes) causing vasculoproliferative changes immunocompromised hosts. A primary difference between is their reservoir ecology. Whereas B. a specialist, only as reservoir, more promiscuous frequently isolated...
Abstract Background The influence of lateral gene transfer on origins and biology in eukaryotes is poorly understood compared with those prokaryotes. A number independent investigations focusing specific genes, individual genomes, or functional categories from various have indicated that does indeed affect eukaryotic genomes. However, the lack common methodology criteria these studies makes it difficult to assess general importance genome evolution. Results We used a phylogenomic approach...
With a realistic threat against biodiversity in rain forests and the sea, sustainable use of natural products is becoming more important. Basic research directed different organisms Nature could reveal unexpected insights into fundamental biological mechanisms but also new pharmaceutical or biotechnological possibilities immediate use. Many strategies have been used prospecting Earth search for novel structure–activity relationships, which has resulted important discoveries drug development....
Infectious disease involving multiple genetically distinct populations of pathogens is frequently concurrent, but difficult to detect or describe with current routine methodology. Cryptosporidium sp. a widespread gastrointestinal protozoan global significance in both animals and humans. It cannot be easily maintained culture infections strains have been reported. To explore the potential use single cell genomics methodology for revealing genome-level variation clinical samples from...
The type IV secretion system (TFSSs) is a multifunctional family of translocation pathways that mediate the transfer DNA among bacteria and deliver proteins to eukaryotic cells during bacterial infections. Horizontal transmission has dominated evolution TFSS, as demonstrated here by lack congruence between tree topology inferred from components TFSS presumed species divergence pattern. A parsimony analysis suggests conjugation represents ancestral state effector molecules occurred...
In order to improve genotyping and epidemiological analysis of Cryptosporidium spp., genomic data need be generated directly from a broad range clinical specimens. Utilizing robust method that we developed for the purification generation amplified target DNA, present its application successful isolation whole-genome sequencing 14 different hominis patient Six isolates subtype IbA10G2 were analyzed together with single representative each 8 other subtypes: IaA20R3, IaA23R3, IbA9G3, IbA13G3,...
Lateral Gene Transfer (LGT) has recently gained recognition as an important contributor to some eukaryote proteomes, but the mechanisms of acquisition and fixation in eukaryotic genomes are still uncertain. A previously defined norm for LGTs microbial eukaryotes states that majority genes involved metabolism, typically localized one by one, surrounded vertically inherited on chromosome, phylogenetics shows a broad collection bacterial lineages have contributed transferome.A unique 34 kbp...
We are interested in quantifying the contribution of gene acquisition, loss, expansion and rearrangements to evolution microbial genomes. Here, we discuss factors influencing genome divergence based on pair-wise comparisons closely related strains species with different lifestyles. A particular focus is intracellular pathogens symbionts genera Rickettsia, Bartonella BUCHNERA: Extensive loss restricted access phage plasmid pools may provide an explanation for why single host normally less...
Background The genome of Leishmania major harbours a comparably high proportion genes prokaryote origin, acquired by lateral gene transfer (LGT). Some these are present in closely related trypanosomatids, while some detected only. We have evaluated the impact and destiny LGT genus Leishmania. Methodology/Principal Findings To study dynamics fate LGTs we performed phylogenetic, as well nucleotide amino acid composition analyses within orthologous groups A set universal trypanosomatid was...
It has been suggested that Rickettsia Palindromic Elements (RPEs) have evolved as selfish DNA mediate protein sequence evolution by being targeted to genes code for RNA and proteins. Here, we examined the phylogenetic depth of two RPEs are located close encoding elongation factors Tu (tuf) G (fus) in Rickettsia. An exceptional organization factor was found all 11 species examined, with complete or partial identified downstream tuf gene (RPE-tuf) six fus (RPE-fus) 10 species. A reconstruction...
With a realistic threat against biodiversity in rain forests and the sea, sustainable use of natural products is becoming more important. Basic research directed different organisms Nature could reveal unexpected insights into fundamental biological mechanisms but also new pharmaceutical or biotechnological possibilities immediate use. Many strategies have been used prospecting Earth search for novel structure-activity relationships, which has resulted important discoveries drug development.