A5065522623- interferon and immune responses
- Herpesvirus Infections and Treatments
- RNA regulation and disease
- Hereditary Neurological Disorders
- Cytomegalovirus and herpesvirus research
- RNA Research and Splicing
- Immune Response and Inflammation
- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Viral Infections and Immunology Research
University of Georgia
2024
Kettering University
2018-2021
Human herpes simplex virus 1 (HSV-1) encephalitis can be caused by inborn errors of the TLR3 pathway, resulting in impairment CNS cell-intrinsic antiviral immunity. Deficiencies pathway impair immunity to vesicular stomatitis (VSV) and HSV-1 fibroblasts, cortical but not trigeminal neurons. The underlying molecular mechanism is thought involve impaired IFN-α/β induction recognition dsRNA viral intermediates or by-products. However, we show here that human controls constitutive levels IFNB...
Significance We previously demonstrated that induced pluripotent stem cell (iPSC)-derived cortical neurons from HSV-1 encephalitis patients with Toll-like receptor 3 (TLR3) pathway deficiencies are highly susceptible to HSV-1, due impairment of autonomous TLR3-IFN immunity. In this study we present a protocol for efficient derivation/purification trigeminal ganglion (TG) human iPSCs. The resulting TG sensory identity and exhibit robust biological function. also show play distinct roles in...