Zhenhua Fang

ORCID: 0000-0003-0596-176X
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About
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Research Areas
  • Foot and Ankle Surgery
  • Orthopedic Surgery and Rehabilitation
  • Diabetic Foot Ulcer Assessment and Management
  • Tendon Structure and Treatment
  • Bone fractures and treatments
  • Lower Extremity Biomechanics and Pathologies
  • Particle Dynamics in Fluid Flows
  • Bone health and treatments
  • Electromagnetic Fields and Biological Effects
  • Musculoskeletal Disorders and Rehabilitation
  • Bone and Joint Diseases
  • Erosion and Abrasive Machining
  • Nail Diseases and Treatments
  • Sports injuries and prevention
  • Coal Combustion and Slurry Processing
  • Virus-based gene therapy research
  • Musculoskeletal synovial abnormalities and treatments
  • Hemoglobinopathies and Related Disorders
  • Macrophage Migration Inhibitory Factor
  • Circular RNAs in diseases
  • Gout, Hyperuricemia, Uric Acid
  • Ear and Head Tumors
  • Sarcoma Diagnosis and Treatment
  • Intraoperative Neuromonitoring and Anesthetic Effects
  • Soft tissue tumors and treatment

Wuhan Puai Hospital
2013-2024

Wuhan Sports University
2024

East China University of Science and Technology
2024

Hainan Agricultural School
2018-2023

First Affiliated Hospital of GuangXi Medical University
2023

Guangxi Medical University
2023

Huazhong University of Science and Technology
2010-2020

Medizinische Hochschule Hannover
2013

Huazhong University of Science and Technology Hospital
2013

Huangshi Central Hospital
2011

The Wnt/β-catenin signaling pathway is associated with the pathogenesis of steroid-induced osteonecrosis. Our investigation studied whether aberrant CpG island hypermethylation FZD1 gene was present in patients osteonecrosis femoral head (ONFH), which results inactivation and subsequent cell dysfunction. Bone marrow collected from proximal femurs steroid-associated ONFH (n = 21) new neck fractures 22), then mesenchymal stem cells (MSCs) were isolated. We investigated viability, transcription...

10.1038/s12276-019-0220-8 article EN cc-by Experimental & Molecular Medicine 2019-02-01

We previously demonstrated that transmissible gastroenteritis virus (TGEV) could induce apoptosis through caspase signaling. However, was not completely prevented by caspases inhibitors, suggesting there may be a caspase-independent pathway involved in TGEV-induced cell apoptosis. In this study, we investigated the regulation of apoptosis-inducing factor (AIF) on apoptotic pathway. Results indicated AIF translocated from mitochondria to nucleus during TGEV infection, and inhibitor,...

10.1292/jvms.18-0104 article EN Journal of Veterinary Medical Science 2018-01-01

Objective Many different techniques have been described for performing tibiotalocalcaneal arthrodesis ( TTCA ) in patients with severe hindfoot disorders such as failed ankle arthroplasty and joint subsequent subtalar arthritis. The use of straight retrograde intramedullary nails is extremely limited because they may interfere normal heel valgus position risk damaging the lateral plantar neurovascular structures. Curved designed to overcome these shortcomings. purpose this single surgeon...

10.1111/os.12171 article EN other-oa Orthopaedic Surgery 2015-05-01

Abstract Background Traditional Scarf osteotomy (TSO) is an effective procedure with a good record in moderate to severe hallux valgus (MSHV) surgery. In order overcome shortcomings of TSO, Modified Rotary (MRSO) was introduced this study, which aimed compare the clinical and radiological outcome patients treated MRSO or TSO. Methods Of 175 (247 feet) MSHV, 100 (138 75 (109 TSO were evaluated according relevant indicators twenty-four months follow-up. Pre-surgical post-surgical HVA, IMA,...

10.1186/s12891-023-07156-5 article EN cc-by BMC Musculoskeletal Disorders 2024-01-13

Intramedullary screw (IMS) fixation was wildly used in fifth metatarsal base fractures (FMBFs) and the results were satisfactory. However, comminuted osteoporosis or small displaced avulsion FMBFs, anatomical reduction stable could not be achieved with IMS. The Locking Compression Plate (LCP) distal ulna hook plate a novel alternative method. aim of this retrospective cohort study to determine if LCP resulted improved outcomes compared traditional IMS FMBFs. Of 43 patients 18 treated 25...

10.1186/s12891-017-1766-z article EN cc-by BMC Musculoskeletal Disorders 2017-09-26

Chondroblastoma is a rare tumor. It usually benign; however, it can have an aggressive course before or after operative treatment, even resulting in pulmonary metastases. The foot location for chondroblastoma, and to our knowledge, chondroblastoma occurring the navicular bone has not been reported previously English literature. We describe case of associated with aneurysmal cyst. Treatment consisted curettage, phenolization, allograft. patient was able resume normal activities there no...

10.1186/1477-7819-11-50 article EN cc-by World Journal of Surgical Oncology 2013-02-28

Scarf osteotomy (SO) was broadly applied in moderate to severe hallux valgus (MSHV), and the results were satisfactory. However, due complicated pathologic changes valgus, ideal surgical treatment is still controversial. Transfer of abductor hallucis tendon combined with (TAHTCSO) an innovative alternative technique. This retrospective cohort study aimed define if TAHTCSO mode resulted improved outcomes as compared single SO MSHV.Of 73 patients (92 ft) MSHV, 36 (45 treated through 37 ones...

10.1186/s12891-019-2860-1 article EN cc-by BMC Musculoskeletal Disorders 2019-10-20

Giant cell tumor of the tendon sheath (GCTTS) is known to be a benign, slow growing originating in or soft tissue. In earlier descriptions, Jaffe et al. regarded GCTTS, pigmented villonodular synovitis (PVNS) and rare bursitis as belonging spectrum lesions1. More recently it has been concluded, on basis clinical, evidence-based diagnoses histological observations, that GCTTS distinct type neoplasm possessing unique set characteristics2. may occur at any age. The ages patients range from 6 65...

10.1111/j.1757-7861.2011.00137.x article EN Orthopaedic Surgery 2011-07-25

Butylparaben (BuP) is regarded as a widespread pollutant, which has potential risk to aquatic organisms. Turtle species are an important part of ecosystems, however, the effect BuP on turtles not known. In this study, we evaluated intestinal homeostasis Chinese striped-necked turtle (Mauremys sinensis). We exposed concentrations (0, 5, 50, and 500 μg/L) for 20 weeks, then investigated composition gut microbiota, structure intestine, inflammatory immune status. found exposure significantly...

10.1016/j.ecoenv.2023.115193 article EN cc-by-nc-nd Ecotoxicology and Environmental Safety 2023-06-29

Fang, Zhenhua MD; Waizy, Hazibullah Berger, Stefan Stukenborg-Colsman, Christina Plaass, Christian MD Author Information

10.2106/jbjs.cc.m.00031 article EN JBJS Case Connector 2013-08-28

This study aims to evaluate the impact of accelerated rehabilitation nursing on perioperative outcomes in patients with calcaneal fractures. A total 101 fractures admitted from December 2020 2022 were included this study. Patients randomly assigned an observation group (OG) 51 receiving surgical and a control (CG) 50 conventional nursing. Outcomes assessed patient satisfaction, visual analog scale (VAS) scores before after surgery, swelling reduction time, complication rates. The...

10.1097/md.0000000000039409 article EN cc-by-nc Medicine 2024-10-11

Chronic syndesmotic instability (CSI) can be associated with severe long-term pain and disability. This study aimed to investigate the risk factors development of CSI in patients who underwent conservative treatment after first episode acute ankle sprain (AAS) that did not result a satisfactory outcome.

10.1177/10711007241291051 article EN Foot & Ankle International 2024-11-19

Magnetic resonance imaging (MRI) T2* is the gold standard for detecting iron deposition in cardiac tissue, but technique has limitations and cannot be fully performed paediatric thalassemia patients. The aim of this study was to analyse clinical data identify other predictors deposition. A retrospective analysis on 370 children with β-TM. According MRI results, patients were allocated a group noncardiac group. Multivariate revealed that genotype corrected QT interval associated deposition,...

10.1007/s00431-023-05300-w article EN cc-by European Journal of Pediatrics 2023-11-08

Objective To investigate the clinical effects of tibiotalocalcaneal arthrodesis (TTCA) using a retrograde intramedullary nail with valgus curve. Methods At our department, 22 patients underwent TTCA curve from June 2009 to January 2014 and were available for complete follow-up. They 12 men 10 women, aged 46 79 years (average, 62.2 years). There 3 cases primary ankle osteoarthritis, 9 ones traumatic arthritis, one arthritis secondary severe talar avascular necrosis, progressive...

10.3760/cma.j.issn.1671-7600.2016.09.003 article EN Zhonghua chuangshang guke zazhi 2016-09-15
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