A5033153045- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Liver Disease Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Computational Drug Discovery Methods
- Infective Endocarditis Diagnosis and Management
- Cardiac Health and Mental Health
- Cardiovascular Health and Disease Prevention
- Liver Disease and Transplantation
- Pharmacovigilance and Adverse Drug Reactions
- Apelin-related biomedical research
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Gut microbiota and health
- Cardiovascular Issues in Pregnancy
- DNA Repair Mechanisms
- Cardiac tumors and thrombi
- Gallbladder and Bile Duct Disorders
- Infectious Aortic and Vascular Conditions
- Cardiac Imaging and Diagnostics
Victor Babeș University of Medicine and Pharmacy Timișoara
2016-2025
Institute e-Austria Timisoara
2024-2025
West University of Timişoara
2016-2025
Drug repurposing has become a widely adopted strategy to minimise research time, costs, and associated risks. Combinations of protease inhibitors such as lopinavir darunavir with ritonavir have been repurposed treatments for COVID-19. Although lopinavir-ritonavir (LPV/r) darunavir-ritonavir (DRV/r) shown in vitro efficacy against COVID-19, the results human studies inconsistent. Therefore, our objective was compare LPV/r DRV/r COVID-19 patients admitted tertiary centre Romania. A clinical...
Background/Objectives: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are prevalent neurological complications following cardiac surgery, significantly affecting patient recovery long-term outcomes, including increased risk of persistent impairment, functional decline, mortality. Understanding the underlying mechanisms factors for POD/POCD is crucial improving perioperative management. This study aimed to investigate relationship between systemic inflammation,...
Gallstone disease (GSD) is more commonly presented in aged people.The purpose of the study was to explore insights metabolic performance bacterial species from gut microbiota as well clinical background middle-aged and elderly patients with GSD.This an observational concerning 120 research participants. Of those, 90 symptomatic GSD addressed for cholecystectomy, average age 59.83 ± 15.32 years: 45 cholesterol rich gallstones (CGSs), pigment (PGSs) 30 healthy controls joined this study....
Purpose: This study aimed to explore inflammatory biomarkers, stool's functional bacterial groups and their possible link portal vein thrombosis (PVT) in patients with liver cirrhosis (LC). Materials Methods: An observational of 300 participants: 200 inhospital cirrhotic patients, who met inclusion criteria, equally assigned into two groups, based on the presence or absence PVT 100 healthy controls was carried out. Results: The group displayed significant differences related older age,...
Abstract The sodium-glucose-cotransporter 2 inhibitors (SGLT2i) are the blockbuster antidiabetic drugs that exert cardiovascular protection via pleiotropic effects. We have previously demonstrated empagliflozin decreased monoamine oxidase (MAO) expression and oxidative stress in human mammary arteries. present study performed overweight, non-diabetic cardiac patients was aimed to assess whether two widely prescribed SGLT2i decrease atrial MAO alleviate elicited by exposure angiotensin (ANG2)...
Gallstone disease (GSD) represents one of the most frequent digestive disorders, highly reported in female gender. The purpose study was to explore clinical and gut microbiota particularities patients with postcholecystectomy syndrome (PCS) possible relationship between dysbiosis (DB) abdominal complaints.In total, 129 participants: 104 outpatients divided into two equal groups, 52 PCS (+), (-) 25 healthy controls were consecutively enrolled this observational study. Patients underwent...
Sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare liver vascular condition, potentially life-threatening, with clinical signs of portal hypertension, frequently reported in relation to bone marrow transplantation and possibly non-transplantation-related chemotherapy. We report the case 65-year-old female patient who insidiously developed fatigue, mild tenderness right upper abdominal quadrant, hepato-splenomegaly slight weight gain consecutive ascites development, as...
Congenital heart defects (CHDs) are among the most frequent congenital defects, and they significantly burden healthcare system due to their high mortality rate cost of care for survivors. We aimed highlight incidence CHDs in a tertiary center Western Romania.
Portal vein thrombosis (PVT) continues to be challenging, due its versatile features and associated clinical pitfalls. This study aimed explore whether gut microbiota imbalance (GMI) could alter presentation short term outcome in cirrhotic patients with PVT. We conducted a cross-sectional exploratory study, concerning 50 consecutive PVT recruited during hospitalization. Consecutive stool microbiological exams, they were assigned into two groups: 25 GMI positive as group negative comparison...
Although remdesivir (GS-5734) has recently demonstrated clinical benefits against the pandemic outbreak of coronavirus disease 2019 (COVID-19), neuropsychological adverse reactions (ADRs) remain to be examined in real-world settings. Therefore, we aimed identify and characterize ADRs associated with use.We obtained data for this international pharmacovigilance cohort study from individual case safety reports (ICSRs) a World Health Organization database (VigiBase) first report on February 17,...
Background/Objectives: Thoracic aortic aneurysms (TAA) represent medical conditions having causes that can range from genetic determinations to various risk factors, potential life-threatening complications, the familial TAA (FTAA) being a cluster of non-syndromic thoracic aneurysms. This review aims emphasize importance testing in patients diagnosed with aneurysms, implications accounting for roughly 20% these cases. The reported case presents patient who was genetically tested 10 years...
Cutaneous melanoma (CM) represents a severe skin cancer with rising incidence at present and limited treatment options. 5-Fluorouracil (5-FU) is widely used, including for CM; however, the innate resistance of this to conventional therapy remains problematic. Quercetin (QUE) flavonoid that can sensitize cells antitumor agents such as 5-FU. However, potential sensitization capability CM 5-FU has scarcely been determined, investigated herein. Therefore, A375 were tested in terms their cell...