A5065130992- Essential Oils and Antimicrobial Activity
- Advanced Drug Delivery Systems
- Protein Hydrolysis and Bioactive Peptides
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticle-Based Drug Delivery
- Supramolecular Self-Assembly in Materials
- Nanocomposite Films for Food Packaging
- Nanoparticles: synthesis and applications
- Natural product bioactivities and synthesis
- Curcumin's Biomedical Applications
- Respiratory viral infections research
- Antimicrobial Peptides and Activities
- Toxoplasma gondii Research Studies
- Influenza Virus Research Studies
- Graphene and Nanomaterials Applications
- Advancements in Transdermal Drug Delivery
- Medicinal Plants and Neuroprotection
- Skin Protection and Aging
- Synthesis and biological activity
- SARS-CoV-2 and COVID-19 Research
- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- biodegradable polymer synthesis and properties
- Phytochemistry and Biological Activities
- Piperaceae Chemical and Biological Studies
Yıldız Technical University
2014-2025
Biotechnology Research Center
2022-2024
Health & Life (Taiwan)
2021
A new coumarin derivative, 7-((8-(4-benzylpiperidin-1-yl)octyl)oxy)-4-methyl-2H-chromen-2-one (C3), was synthesized by two-step alkylation reaction of 7-hydroxy-4-methyl coumarin. The structure and purity the compound were characterized its 1H 13C NMR, FT-IR LC-MS spectral data. DNA binding interaction C3 evaluated using UV–vis spectrophotometric viscosimetric methods. These experiments showed that bound in intercalative mode. antioxidant activity DPPH method, results displayed had radical...
The aim of this study was to obtain essential oil (LNEO) from the
Background/Objectives: This study aimed to develop cinnamon bark essential oil (CEO), orange peel oil(OEO) and the combination of these two oils (OEO-CEO) loaded PLGA nanoparticles prevent dental caries investigate their effectiveness in silico vitro methods. Methods: EO were produced by single emulsion method. Detailed characterization studies performed using different methods, controlled release profile was obtained. The antibacterial activity developed formulations investigated on S....
Hyperpigmentation is a crucial dermatological disorder. This study aims to formulate nanoemulsion formulation containing chlorogenic acid (CA) for hyperpigmentation treatment, carry out characterization studies, and investigate its efficacy safety in vitro silico analysis. In line with this purpose, CA nanoemulsions (CA-NEs) were developed using the ultrasonic homogenization method. Accelerated stability tests performed examine kinetic thermodynamic of CA-NEs ascertain presence any issues....
Ultraviolet (UV) rays damage DNA, causing adverse effects such as photoaging and cancer on the skin. For well-being of individuals, there is a need to develop innovative skin products with high effectiveness using protective therapeutic agents. In this context, in our study, A nanoemulsion (NE) formulation containing Ylang-ylang essential oil (YO), which has many biological active properties antimicrobial, antioxidant, anti-inflammatory, anticancer, was produced by ultrasonic emulsification...
This study, it was aimed to develop a topical piperine nanoemulsion (P-NE) using an ultrasonic emulsification process find alternative treatment option for some hypopigmentation disorders such as vitiligo. Results showed that 150 mg loaded NE with 1:2 oil phase Smix ratio and manufactured 20 min ultrasonication duration the pre-emulsification step most durable formulation mean globule size of 216.00 ± 2.65, PdI value 0.094 0.02 zeta potential -27.50 2.48 mV. After three months storage,...
The increase in the aging population worldwide has led scientists to turn research prevent process. In this context, synthetic peptides emerge as candidate molecules for developing new anti-aging products. This study aims investigate possible interactions of Syn-Ake, a peptide, with matrix metalloproteinases (MMPs) and Sirtuin 1 (SIRT1), which are targets activities
Phe-Tyr dipeptide which was investigated in Wakame food with greatest ACE-inhibitory activity is used as a pharmaceutical drug for the treatment of hypertension, cardiovascular diseases, and diabetic nephropathy. To improve bioavailability Phe-Tyr, delivery system based on poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded (Phe-Tyr-PLGA NPs) treating hypertension diseases prepared this study. In experiments, poly(lactic-co-glycolic dipeptide-loaded PLGA were using double emulsion...
Abstract In this study, piperine was investigated as a drug molecule due to its analgesic and anti‐inflammatory properties. Piperine encapsulated with poly(lactic‐co‐glycolic acid) (PLGA) in order increase bioavailability for topical applications. Characterization of PLGA nanoparticles (NPs) were performed spectroscopic imaging methods. It found that the NPs successfully prepared according analyses. The encapsulation efficiency loading capacity calculated 99% 3%, respectively. vitro release...
N-acetylcarnosine (NAC), a dipeptide with powerful antioxidant properties that is extensively used as pharmaceutical prodrug for the treatment of cataract and acute gastric disease, was investigated by molecular dynamics GROMACS program in order to understand solvent effect on peptide conformation molecule component drug which presents substantial information where molecules bind how they exert their effects. Besides, docking simulation performed using AutoDock Vina identify kind interaction...
Background: Sulpiride, which has selective dopaminergic blocking activity, is a substituted benzamide antipsychotic drug playing prominent role in the treatment of schizophrenia, more and primarily blocks dopamine D2 D3 receptor. Objective: This study two main objectives, firstly; molecular modeling studies (MD Docking, ADME) were conducted to define profile sulpiride sulpiridereceptor interactions, another synthesize polymeric nanoparticles with chitosan, having advantage slow/controlled...
Abstract:: Respiratory viruses have caused many pandemics from past to present and are among the top global public health problems due their rate of spread. The recently experienced COVID-19 pandemic has led an understanding importance rapid diagnostic tests prevent epidemics difficulties developing new vaccines. On other hand, emergence resistance existing antiviral drugs during treatment process poses a major problem for society systems. Therefore, there is need approaches diagnosis,...
Toxoplasmosis is caused by T. gondii and can create serious health problems in humans also worldwide economic harm. Because of the clinical veterinary importance toxoplasmosis, its timely accurate diagnosis has a major impact on disease-fighting strategies. surface antigen 1 (SAG1), an immunodominant-specific antigen, often used as diagnostic tool. Therefore, aim this study was optimization novel fluorescein isothiocyanate (FITC) labeling SAG1-specific IgY antibody to show potential for...