A5102945996- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Virology and Viral Diseases
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Vitamin D Research Studies
- T-cell and B-cell Immunology
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
Chungbuk National University
2017-2021
Abstract Tolerogenic dendritic cells (tDCs) represent a promising tool for cellular therapy against autoimmune diseases, allergies, and transplantation rejection. Numerous pharmacological agents are known to induce tDC generation. Minocycline, which has long been used as broad-spectrum antibiotic, was recently shown significantly increase the generation of DCs with regulatory properties. Here, we examined effect combination minocycline dexamethasone, rapamycin, vitamin D3, interleukin...
The active form of vitamin D3, 1,25-dihydroxyvitamin D3 (aVD3), is known to exert beneficial effects in the treatment autoimmune diseases because its immunosuppressive effects. However, clinical application aVD3 remains limited potential side effects, particularly hypercalcemia. Encapsulation within biodegradable nanoparticles (NPs) would enhance delivery antigen presenting cells, while preventing systemic aVD3. In present study, polymeric NPs containing ovalbumin (OVA) and (NP[OVA+aVD3])...
Smallpox, a disease caused by the variola virus, is one of most dangerous diseases and had killed numerous people before it was eradicated in 1980. However, smallpox has emerged as threatening bio-terrorism agent; first- second-generation vaccines have been controversial severe adverse reactions, new demands for safe raised some attenuated developed. We developed cell culture-based highly third-generation vaccine candidate KVAC103 strain 103 serial passages Lancy-Vaxina derived from Lister...
It has been reported worldwide that the Zika virus (ZIKV) could be transmitted through placentas and sexual contact. ZIKV can also cause Guillain-Barre syndrome, microcephaly neurological abnormalities. However, there are no approved vaccines available. We constructed six DNA vaccine candidates tested immunogenicity. Tandem repeated envelope domain Ⅲ (ED × 3) induced highly total IgG neutralization antibody, as well CD8+ T cell responses. Also, stem region-removed (E ΔSTEM) elicited a robust...