A5028306879- Cancer Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Polyamine Metabolism and Applications
- Dental Implant Techniques and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Bone and Dental Protein Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Oral and Maxillofacial Pathology
- Antimicrobial Peptides and Activities
- Bone health and treatments
- Connective tissue disorders research
- Nanocomposite Films for Food Packaging
- Glycosylation and Glycoproteins Research
- dental development and anomalies
- Vascular Malformations and Hemangiomas
- Cancer and Skin Lesions
- Peptidase Inhibition and Analysis
- Dental Trauma and Treatments
- Sarcoma Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Dental Radiography and Imaging
- Tumors and Oncological Cases
- Ubiquitin and proteasome pathways
Chulalongkorn University
2007-2022
Developing scaffolds with a three-dimensional porous structure and adequate mechanical properties remains key challenge in tissue engineering of bone. These must be biocompatible biodegradable to effectively support osteoblastic cell attachment, proliferation, differentiation. This study successfully fabricated chitosan-bacterial cellulose (CS-BC) composite scaffold using the solvent casting/particle leaching (SCPL) technique, NaOH/urea solution as sodium chloride crystals porogen. The...
Developing scaffolds with a three-dimensional porous structure and adequate mechanical properties remains key challenge in tissue engineering of bone. These must be biocompatible biodegradable to effectively support osteoblastic cell attachment, metabolic activity, differentiation. This study successfully fabricated chitosan–bacterial cellulose (CS–BC) composite scaffold using the solvent casting/particle leaching (SCPL) technique, NaOH/urea solution sodium chloride crystals as porogen. The...
Osteopontin (OPN) is an adhesive, matricellular glycoprotein, whose expression elevated in many types of cancer and has been shown to facilitate tumorigenesis vivo. To understand the role OPN human skin cancer, this study designed determine whether expressed premalignant [solar/actinic keratosis (AK)] malignant lesions such as squamous cell carcinomas (SCC) basal (BCC), well normal exposed or not sunlight. Immunohistochemical analyses showed that SCC (20/20 cases) AK (16/16 cases), which are...
Osteogenesis imperfecta (OI) is mainly characterized by bone fragility and Ehlers-Danlos syndrome (EDS) connective tissue defects. Mutations in COL1A1 or COL1A2 can lead to both syndromes. OI/EDS overlap mostly caused helical mutations near the amino-proteinase cleavage site of type I procollagen. In this study, we identified a Thai patient having OI III, EDS, brachydactyly, dentinogenesis imperfecta. His dentition showed delayed eruption, early exfoliation, severe malocclusion. For first...
The Akt/mTOR pathway is activated in many malignancies, including oral squamous cell carcinoma (OSCC). However, the role of verrucous (OVC), a low-grade variant OSCC, remains unknown. Thus, objective this study was to investigate activation level important markers OVC and compare results with OSCC samples.The expression p-Akt (Thr308), (Ser473), p-RPS6 evaluated by immunohistochemistry 30 cases, 18 control cases (normal epithelium overlying fibromas). Statistical analysis performed determine...
Abstract Objective The effect of different deproteinized bovine bone mineral (DBBM) particle sizes on healing in maxillary sinus floor augmentation remains unclear. This study compared the newly formed tissue and angiogenesis‐related after using large or small DBBM particles. Materials Methods Overall 32 patients were randomly divided into two groups either (1–2 mm) (0.25–1 particles for augmentation. After 6 months, mineralized volume was calculated micro‐computed tomography (micro‐CT)...
The prognosis of advanced stage head and neck squamous cell carcinoma (HNSCC) has remained unimproved for the past decades. Therefore, novel diagnostic markers treatment options are required. Recently, an inhibitor immune checkpoint program death ligand-1 (PD-L1), was approved by FDA, used in HNSCC patients. Histatins (HTNs), one common antimicrobial peptides saliva, have demonstrated wound healing antifungal capabilities other functions on oral epithelium. Dysregulation HTN1 HTN3 also been...
To investigate the role of phosphatase and tensin homolog (PTEN) in dental pulp cells (hDPs) adipose-derived mesenchymal stem (hADSCs).Genetic variant was identified with exome sequencing. The hDPs isolated from a patient Cowden syndrome were investigated for their proliferation, osteogenesis, adipogenesis, gene expression compared controls. normal hADSCs treated PTEN inhibitor, VO-OHpic trihydrate (VOT), to effect inhibition.A heterozygous nonsense variant, c.289C>T (p.Gln97*), patient's...