A5035716169- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Infection Control in Healthcare
- Microbial Metabolism and Applications
- Antibiotic Use and Resistance
- Infection Control and Ventilation
- Plant Pathogenic Bacteria Studies
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Probiotics and Fermented Foods
- Pneumonia and Respiratory Infections
- Dental Research and COVID-19
- Parasites and Host Interactions
- Escherichia coli research studies
- Innovation and Socioeconomic Development
- Urinary Tract Infections Management
Kenya Medical Research Institute
2017-2024
United States Army Medical Research Directorate - Africa
2017-2021
Abstract Background Healthcare-associated infections (HAIs) are often caused by multidrug-resistant (MDR) bacteria contaminating hospital environments which can cause outbreaks as well sporadic transmission. Methods This study systematically sampled and utilized standard bacteriological culture methods to determine the numbers types of MDR Enterococcus faecalis / faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii , Pseudomonas aeruginosa, Enterobacter species,...
Introduction: Uropathogenic Escherichia coli (UPECs) are a significant cause of urinary tract infections (UTIs). In Kenya, UTIs typically treated with β-lactam antibiotics without antibiotic susceptibility testing, which could accelerate resistance among UPEC strains. Aim: This study determined the occurrence producing extended-spectrum β-lactamases (ESBLs), genes conferring to β-lactams, and phylogenetic groups associated ESBLs in Kenyan UPECs. Methodology: Ninety-five isolates from six...
Abstract Background The increase and spread of virulent-outbreak associated, methicillin vancomycin resistant (MRSA/VRSA) Staphylococcus aureus require a better understanding the resistance virulence patterns circulating emerging strains globally. This study sought to establish phenotype, 32 non-duplicate clinical MRSA MSSA S. isolates from four Kenyan hospitals , identify their genes determine genetic relationships with global strains. Methods Antimicrobial susceptibility profiles were...
Microbial monitoring of hospital surfaces can help identify target areas for improved infection prevention and control (IPCs). This study aimed to determine the levels variations in bacterial contamination high-touch five Kenyan hospitals contributing modifiable risk factors. A total 559 four departments identified as high hospital-acquired infections were sampled examined using standard bacteriological culture methods. Bacteria detected 536/559 (95.9%) surfaces. The median load on all was...
Visceral leishmaniasis is a deadly infectious disease and one of the world's major neglected health problems. Because symptoms infection are similar to other endemic diseases, accurate diagnosis crucial for appropriate treatment. Definitive using splenic or bone marrow aspirates highly invasive, so, serological assays preferred, including direct agglutination test (DAT) rK39 strip test. These tests, however, either difficult perform in field lack specificity some regions (rK39), making...
Purpose . Data on the clonal distribution of Staphylococcus aureus in Africa are scanty, partly due to high costs and long turnaround times imposed by conventional genotyping methods such as spa multilocus sequence typing (MLST), which means there is a need for alternative approaches. This study evaluated discriminatory power, cost time required Kenyan staphylococcal isolates using iPlex MassARRAY compared methods. Methodology. Fifty-four clinical S. from three counties were characterized...
<h3>Background</h3> The EDCTP-funded PREV_PKDL project was designed to: i) advance the clinical development of a vaccine for prevention visceral leishmaniasis (VL)/post kala azar dermal (PKDL) and ii) to gain greater understanding immune determinants treatment outcome, using multidimensional, multiparameter phenotyping patient cohorts recruited across countries Leishmaniasis East Africa Platform (LEAP; Ethiopia, Kenya, Sudan Uganda). Central latter objective establishment distributed Center...
Abstract Staphylococcusaureus strain typing is an important surveillance tool as particular strains have been associated with virulence and community hospital acquired MRSA outbreaks globally. This study sought to determine the circulating types of S.aureus in Kenya establish genes among strains. Clinical isolates from 3 hospitals were sequenced on Illumina Miseq genomes assembled annotated PATRIC. Results demonstrated great diversity identification 6 distinct CC (8,22,15,80,121,152), 8 ST...
Abstract Background Data on the clonal distribution of Staphylococcus aureus in Africa is scanty, partly due to high costs and long turnaround times imposed by conventional genotyping methods such as spa multilocus sequence typing (MLST) warranting need for alternative approaches. This study applied evaluated accuracy, cost time using iPlex massARRAY method Kenyan staphylococcal isolates. Methods Fifty four clinical S. isolates from three counties were characterized massARRAY, MLST methods....