A5008916221- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Glioma Diagnosis and Treatment
- Pesticide and Herbicide Environmental Studies
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Redox biology and oxidative stress
- Educational Games and Gamification
- Biomedical and Engineering Education
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Edible Oils Quality and Analysis
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Educational Leadership and Innovation
- Biochemical and Molecular Research
- Essential Oils and Antimicrobial Activity
- Metabolism and Genetic Disorders
- Acute Lymphoblastic Leukemia research
- Nuts composition and effects
- Ferroptosis and cancer prognosis
- Plant Stress Responses and Tolerance
University of the West of England
2012-2022
North Bristol NHS Trust
2015
University of Bristol
2015
The branched chain aminotransferase enzymes (BCAT) serve as nitrogen donors for the production of 30% de novo glutamate synthesis in rat brain. Despite importance this major metabolite and excitatory neurotransmitter, distribution BCAT proteins human brain (hBCAT) remains unreported. We have studied report, first time, that mitochondrial isoform, hBCATm is largely confined to vascular endothelial cells, whereas cytosolic hBCATc restricted neurons. majority hBCATc-labelled neurons were either...
Background: The human branched chain aminotransferases (hBCATm, mitochondrial and hBCATc, cytosolic) are major contributors to brain glutamate production. This excitatory neurotransmitter is thought contribute neurotoxicity in neurodegenerative
The human branched-chain aminotransferase proteins (hBCATm and hBCATc) are regulated through oxidation S-nitrosation. However, it remains unknown whether they share common redox characteristics to enzymes such as protein disulfide isomerase (PDI) in terms of regulating cellular repair misfolding.Here, similar PDI, the hBCAT showed dithiol-disulfide activity that was mediated an S-glutathionylated mechanism. Site-directed mutagenesis active thiols CXXC motif demonstrates fundamental optimal...
Cytosolic and mitochondrial human branched chain aminotransferase (hBCATc hBCATm, respectively) play an integral role in brain glutamate metabolism. Regional increased levels of hBCATc the CA1 CA4 region Alzheimer's disease (AD) together with hBCATm frontal temporal cortex AD brains, suggest a for these proteins excitotoxicity. Glutamate toxicity is key pathogenic feature several neurological disorders including epilepsy associated dementia, AD, vascular dementia (VaD) Lewy bodies (DLB). To...
Background and research question: Gliomas represent 43% of all solid intracranial tumours, which glioblastomas have the poorest prognosis.Recently, human cytosolic branched7chain aminotransferase protein (hBCATc), metabolises amino acids (BCAA), was identified as a biomarker therapeutic target for carrying wild7type isocitrate dehydrogenase (IDH7WT) genes.However, clinical utility mitochondrial isoform, hBCATm, also BCAAs, not determined nor its potential role in predicting patient survival....
Introduction: Scenario-based learning and gamification have many advantages in comparison to traditional didactic teaching methods, including development of higher-level skills such as analysis evaluation. It is hoped that these simulations provide a real-world experience format accessible students. Integration tools into excelled during the COVID-19 pandemic, an event completely changed education initiated greatest advancement digital date. We discuss our experiences using Resimion, novel...
INTRODUCTION: Recent studies indicated that the human cytosolic branched chain aminotransferase protein (hBCATc), which metabolises amino acids (BCAA), was significantly upregulated in IDH1/2 wild type (WT) glioblastomas and is associated with a worse prognosis compared IDH mutant gliomas. The diagnostic prognostic significance of markers BCAA metabolism currently under investigation. METHOD: 64 glioma tumour samples were for hBCATc, hBCATm BCKDC expression using western blotting IHC. DNA...
Abstract Background : Colorectal cancer is the third most common worldwide, with colon representing 66.7% of cases. Treatment consists surgical resection and chemotherapy; however, this less effective at later stages disease. Gene targeted therapies represent a promising treatment option and, where available, show significant improvement in overall patient survival. The present study investigated genetic alteration occurring used to produce predictive model for Methods data was obtained from...