A5026853195- Hydrogen's biological and therapeutic effects
- Oral health in cancer treatment
- Management of metastatic bone disease
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- bioluminescence and chemiluminescence research
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Blood Coagulation and Thrombosis Mechanisms
- Biochemical effects in animals
- Sulfur Compounds in Biology
- Anesthesia and Neurotoxicity Research
- 3D Printing in Biomedical Research
- Biosensors and Analytical Detection
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- Digital Imaging for Blood Diseases
- Cancer therapeutics and mechanisms
- Neuroscience of respiration and sleep
- Vitamin C and Antioxidants Research
- SARS-CoV-2 detection and testing
- Advanced Biosensing Techniques and Applications
- Liver physiology and pathology
- Pregnancy and preeclampsia studies
- Head and Neck Cancer Studies
University of the West of England
2009-2024
Versiti Blood Center of Wisconsin
2016-2022
DSM (Switzerland)
2020-2021
University of Liverpool
2013
Norsk Hydro (Germany)
2013
Swansea University
2013
Recent advances in wearable sensor technologies offer new opportunities for improving dietary adherence. However, despite their tremendous promise, the potential of chemical sensors guiding personalized nutrition solutions has not been reported. Herein, we present an epidermal biosensor aimed at following dynamics sweat vitamin C after intake pills and fruit juices. Such skin-worn noninvasive electrochemical detection realized by immobilizing enzyme ascorbate oxidase (AAOx) on flexible...
Produced by photosynthesis, oxygen (O2) is a fundamentally important gas in biological systems, playing roles as terminal electron receptor respiration and host defence through the creation of reactive species (ROS). Hydrogen (H2) plays role metabolism for some organisms, such at thermal vents gut environment, but has controlling growth development, disease states, both plants animals. It been suggested medical therapy enhancing agriculture. However, exact mode action H2 systems not fully...
Prior to introduction the clinic, pharmaceuticals must undergo rigorous toxicity testing ensure their safety. Traditionally, this has been achieved using in vivo animal models. However, besides ethical reasons, there is a continual drive reduce number of animals used for purpose due concerns such as lack concordance seen between models and toxic effects humans. Adequate any metabolites are detected can be further complicated if agent administered prodrug form, requiring source cytochrome...
Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe), for example, is well-known anesthetic. The direct targets these gases, cases, remain elusive. Myoglobin hemoglobin known their roles the transport through coordinate interactions with metals (O2, NO, CO) covalent modifications thiols (NO, H2S) amines...
Mesenchymal stem/stromal cells (MSCs) within the bone marrow (BM) are vitally important in forming micro-environment supporting haematopoiesis after myeloablative chemotherapy. MSCs known to be damaged phenotypically and functionally by chemotherapy; however, best our knowledge, persistence of genotoxic effects chemotherapy on BM has not been studied. We therefore aimed evaluate both vitro vivo, using comet micronucleus assays, focussing DNA lesions that may contribute complications patient....
Tumour microenvironments are hallmarked in many cancer types. In haematological malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant from drug-induced cytotoxicity. However, less is known about impact on supportive stroma. Notably, it unknown whether these interactions alter long-term genotoxic damage either direction. The nucleoside analogue cytarabine (ara-C), common therapies, remains the most effective agent for acute myeloid leukaemia, yet one-third of...
Abstract Laminin-γ1 is required for early embryonic development; however, the need laminin-γ1 synthesis in adulthood unknown. A global and inducible mouse model of deficiency was generated to address this question. Genetic ablation Lamc1 gene adult mice rapidly lethal. Despite deletion tamoxifen-induced mutant mice, there minimal change total cardiac, pulmonary, hepatic or renal laminin protein. In contrast, significantly depleted small intestines, which showed crypt hyperplasia dissociation...
Fibrinogen concentration is a major determinant of both clotting and bleeding risk. Clotting disorders cause extensive morbidity mortality, particularly in resource-poor emergency settings. This exacerbated by lack timely intervention informed measurement fibrinogen levels under conditions such as thrombosis or postpartum haemorrhage. There an absence simple, rapid, low-cost, sustainable diagnostic devices for that can be deployed environments. Paper-based analytical are significant interest...
Introduction: Scenario-based learning and gamification have many advantages in comparison to traditional didactic teaching methods, including development of higher-level skills such as analysis evaluation. It is hoped that these simulations provide a real-world experience format accessible students. Integration tools into excelled during the COVID-19 pandemic, an event completely changed education initiated greatest advancement digital date. We discuss our experiences using Resimion, novel...
Devices fabricated using chromatography paper and wax printing, modified with thromboplastin (top left). Distance travelled by plasma samples (bottom right) is proportional to hospital prothrombin time (PT) (main graph) from normal (green) significantly prolonged (red).