A5058604248- HIV, Drug Use, Sexual Risk
- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- HIV/AIDS Research and Interventions
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Homelessness and Social Issues
- Crime, Illicit Activities, and Governance
- Poisoning and overdose treatments
- Pharmaceutical Practices and Patient Outcomes
- Health Policy Implementation Science
- Hepatitis C virus research
- Prenatal Substance Exposure Effects
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Treatment and Access
- Sex work and related issues
- Pain Management and Opioid Use
- Alcohol Consumption and Health Effects
- Schizophrenia research and treatment
- Crime Patterns and Interventions
- Pharmacovigilance and Adverse Drug Reactions
- Child and Adolescent Psychosocial and Emotional Development
- Gambling Behavior and Treatments
- Child Abuse and Trauma
- Adolescent Sexual and Reproductive Health
St. Michael's Hospital
2016-2025
University of California System
2015-2025
University of Toronto
2018-2025
University of California, San Diego
2016-2025
Public Health Ontario
2020-2025
Unity Health Toronto
2020-2024
St Michaels Hospital
2018-2022
Western University
2022
McMaster University
2022
UC San Diego Health System
2021
<h3>Importance</h3> During the COVID-19 pandemic, modified guidance for opioid agonist therapy (OAT) allowed prescribers to increase number of take-home doses promote treatment retention. Whether this was associated with an increased risk overdose is unclear. <h3>Objective</h3> To evaluate whether OAT early in pandemic retention and opioid-related harm. <h3>Design, Setting, Participants</h3> A retrospective propensity-weighted cohort study 21 297 people actively receiving on March 21, 2020,...
Abstract Background The North American opioid overdose crisis is driven in large part by the presence of unknown psychoactive adulterants dynamic, unregulated drug supply. We herein report first detection veterinary compound xylazine Toronto, largest urban center Canada, city’s checking service. Methods Toronto’s Drug Checking Service launched October 2019. Between then and February 2021, 2263 samples were submitted for analysis. service offered voluntarily at harm reduction agencies that...
Canada is experiencing an unprecedented drug toxicity crisis driven by a highly toxic unregulated supply contaminated with fentanyl, benzodiazepine, and other drugs. Safer pilot programs provide prescribed doses of pharmaceutical alternatives to individuals accessing the have been implemented prevent overdose reduce related harms. Given recent emergence these paucity data on implementation challenges, we sought document challenges in their initial phase.We obtained organizational progress...
BackgroundSupervised consumption services (SCS) prevent overdose deaths onsite; however, less is known about their effect on population-level mortality. We aimed to characterise mortality in Toronto, ON, Canada, and establish the spatial association between SCS locations events.MethodsFor this ecological study analysis, we compared crude rates before after implementation of nine Toronto 2017. Data were obtained from Office Chief Coroner Ontario cases accidental death within City for which...
Abstract Background The COVID-19 pandemic had a disproportionate impact on the health and wellbeing of people who use drugs (PWUD) in Canada. However less is known about jurisdictional commonalities differences exposure impacts pandemic-related restrictions competing social risks among PWUD living large urban centres. Methods Between May 2020 March 2021, leveraging infrastructure from ongoing cohorts PWUD, we surveyed 1,025 participants Vancouver ( n = 640), Toronto 158), Montreal 227),...
Abstract Introduction and Aims. Crack cocaine use among illicit drug users is associated with a range of health community harms. However, long‐term epidemiological data documenting patterns risk factors for crack initiation remain limited especially injection users. We investigated longitudinal polydrug in Vancouver, Canada. Design Methods. examined the rate enrolled prospective cohort study Canada between 1996 2005. also used Cox proportional hazards regression analysis to identify...
Illegal drug use continues to be a major threat community health and safety. We used international surveillance databases assess the relationship between multiple long-term estimates of illegal price purity.We systematically searched for longitudinal measures supply indicators impact enforcement-based reduction interventions.Data from identified systems were analysed using an priori defined protocol in which we sought present annual beginning 1990. Data then subjected trend analyses.Data...
Injection drug use remains a primary driver of HIV and HCV-related harms globally. However, there is gap in efforts to prevent individuals from transitioning into injecting. People who inject drugs (PWID) play key role the transition others injecting, while behavioral interventions have been developed address this phenomenon, socio-structural approaches remain unexplored. To that end, we hypothesize certain designed reduce injecting-related risk behaviors may also PWID expose introduce...
Abstract Aim To assess the effect of involuntary drug treatment (IDT) on non‐fatal overdose among people who inject drugs (PWID). Design Longitudinal study. Setting Tijuana, Mexico. Participants Baseline sample 671 PWID included 258 (38.4%) women and 413 (61.6%) men. Measurements Primary independent variables were reported recent (i.e. past 6 months) event (dependent variable) IDT. Substance use day was also examined. Findings From 2011 to 2017, 213 participants (31.7%) a 103 (15.4%) Heroin,...
Abstract Background The increasing incidence of fatal opioid overdose is a public health crisis in Canada. Given growing consensus that this related to the presence highly potent adulterants (e.g., fentanyl) unregulated drug supply, checking services (DCS) have emerged as part comprehensive approach prevention. In Canada’s largest city, Toronto, network DCS launched 2019 prevent and overdose-related risk behaviors. This employs mass spectrometry technologies, with intake sites co-located...