A5088146399- Neurotransmitter Receptor Influence on Behavior
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Methane Hydrates and Related Phenomena
- Marine and coastal ecosystems
- Neuroscience and Neuropharmacology Research
- Veterinary Pharmacology and Anesthesia
- Nicotinic Acetylcholine Receptors Study
- Hydrocarbon exploration and reservoir analysis
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
- Psychedelics and Drug Studies
- Marine Biology and Ecology Research
- Geological Studies and Exploration
- Synthesis and Biological Evaluation
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Ocean Acidification Effects and Responses
- Pharmacological Effects and Assays
- Groundwater and Isotope Geochemistry
- SARS-CoV-2 and COVID-19 Research
- Microbial Metabolic Engineering and Bioproduction
- Geochemistry and Elemental Analysis
Cleveland Clinic
2020-2025
Cleveland Clinic Lerner College of Medicine
2020-2024
Cleveland State University
2016-2024
English Heritage
2021
Woods Hole Oceanographic Institution
2003-2017
American Academy of Orthopaedic Surgeons
2013
American Dental Association
2013
American Association of Neurological Surgeons
2013
College of American Pathologists
2013
University of Missouri
2012
Abstract Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity mortality. However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, representing an drug discovery strategy from existing drugs, could shorten the time reduce cost compared to de novo discovery. In this study, we present integrative, antiviral...
Five centrally acting sympathomimetic amines, d‐amphetamine, d‐methamphetamine, ephedrine, phenmetrazine, and methylphenidate, were studied in man. All of these agents increased blood pressure respiratory rate, produced similar types subiective changes, the excretion epinephrine. With regard to parameters, there was a high concordance between estimates their relative potencies. The potency for different parameters suggests, but does not prove, that five share common mode central action....
A series of morphine-like and nalorphine-like drugs were studied in the nondependent, morphine-dependent cyclazocine-dependent chronic spinal dog. In nondependent dog, three profiles activity found which could be utilized to distinguish between morphine, WIN 35, 197-2 cyclazocine. Propiram, a prototypic partial agonist morphine type, produced effects dogs both precipitated suppressed abstinence as was needed precipitate dogs. 197-2, strong guinea-pig ileum has been shown resistant antagonism...
Naltrexone (EN-1639A) is approximately 17 times more potent than nalorphine as an antagonist in man. It virtually devoid of agonistic activity, including the ability to induce nalorphine-like dysphoric effects. Its duration action longer that naloxone, but shorter cyclazocine. effective orally. When administered a dose level 50 mg/day, it produces degree blockade effects morphine and heroin comparable obtained with 4 mg cyclazocine per day Naltrexone, thus, appears be relatively pure...
Jevsevar, David S. MD, MBA; Brown, Gregory Alexander PhD; Jones, Dina L. PT, Matzkin, Elizabeth G. MD; Manner, Paul A. FRCSC; Mooar, Pekka Schousboe, John T. Stovitz, Steven Sanders, James O. Bozic, Kevin J. Goldberg, Michael Martin, William Robert III Cummins, Deborah Donnelly, Patrick MA; Woznica, Anne MLIS; Gross, Leeaht MPH
The narcotic antagonist naloxone was studied in man to determine if it produced behavioral effects and physical dependence substituted for morphine morphine-dependent subjects. When compared placebo 12 subjects a cross-over design, no or little activity demonstrated while, contrast, the antagonists, nalorphine levallorphan, constricted pupils, responses on subject9s observer9s single-dose opiate questionnaires psychotomimetic sedative-like subjective drug effect questionnaire. In 10...
Methadone hydrochloride produces subjective changes similar to those produced by heroin and is approximately equipotent morphine when both are administered subcutaneously one half as potent orally. Chronically methadone sedation, lethargic apathy, reduction in sexual interest activity, hemodilution, edema. Even patients were receiving tolerant 100 mg/day, drug-seeking behavior was seen. dose level of mg orally physical dependence that morphine, except onset the abstinence syndrome slower....
Multiplication of Salmonella enteritidis was inhibited in vitro by buffered suspensions fecal material freshly removed from the large intestine normal mice. Most effective obtained cecum and transverse colon. Inhibitory activity not impaired sterilization heat or filtration. From such materials were isolated acetic butyric acids concentrations which vitro. The degree inhibitory colon content mixtures two fatty conditioned pH favored anaerobiosis. Effective inhibition occurred at slightly...
Determinations of pH, Eh, and concentrations acetic, butyric lactic acids were made on the content cecum transverse colon groups mice killed 1, 3, 5 days after oral administration 50 mg streptomycin. Control observations untreated are reported in preceding communication. Heat-killed supenatants suspensions bowel tested vitro for their ability to inhibit multiplication our standard streptomycin-resistant strain Salmonella enteritidis during aerobic anaerobic incubation. Also like fashion...
The release of particulate-phase trace metals due to sediment resuspension has been investigated by combining erosion chamber experiments that apply a range shear stresses typically encountered in coastal environments with stress record simulated hydrodynamic model. Two sites contrasting chemistry were investigated. Sediment particles enriched silver, copper, and lead, 4−50 times greater than the bulk surface-sediment content, first be eroded. As shear-stress level was increased chamber,...
Narcotic analgesics and related drugs act as agonists on several receptors that are responsible for their effects pain perception, mood feeling state, respiration, well other pharmacologic actions. Naloxone is the first discovered antagonist devoid of agonistic activity appears to be a competitive at receptors. The ability naloxone displace or prevent binding narcotics partly its antagonistic effects. rectify narcotic-depressed homeostats precipitate abstinence also activity. Certain...
Experiments aimed at comparing acute and chronic tolerance to, as well physical dependence on, morphine were conducted in both high (C5-C6) low (T-10) spinal dogs. Abstinence signs, precipitated by nalorphine, originating supraspinal portions of the nervous system cord structures below level transection studied. Acute develops cord; however, develop more rapidly completely structures. The has a capacity equal to or greater than that dependence. These findings indicate are, an extent,...
The Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures evidence-based clinical practice guideline was codeveloped by the American Academy Surgeons (AAOS) and Association. This replaces previous AAOS Information Statement, "Antibiotic Prophylaxis Bacteremia With Joint Replacement," published 2009. Based on best current evidence a systematic review studies, three recommendations have been created to guide prevention orthopaedic implant infections patients...
Pentazocine produces morphine‐like subjective effects. A dose of 60 mg. per 70 Kg. effects which more closely resemble those nalorphine than morphine. will not suppress abstinence symptoms in subjects dependent on either or 240 day is 1/50 as potent precipitating subiects morphine day. Long‐term administration pentazocine dependence has elements both and dependence. It concluded that an abuse potential less with but greater nalorphine.
Naloxone is an opioid antagonist with little, it any, agonistic activity. Cyclazocine, on the other hand, in addition to antagoniZing effects of morphine, produces man, some which resemble produced by morphine and do not. The interaction between naloxone cyclaZOcine Wll8 assessed 8 subjects. antagonized miotic respiratory depressant as well behaVioral subjective cyclazocine.