Fourteen patients with schistosomiasis of the spinal cord are described. They fall into two groups: 7 had clinical and computer-assisted myelographic evidence lesions in conus medullaris or cauda equina, both. The picture remaining was usually that acute subacute transverse myelitis normal equivocal CT appearances. Granulomas containing bilharzial ova were found 2 female swelling subjected to laminectomy biopsy. In 1 these identified as S. haematobium while second, unidentified found. A...

A 49-year-old South African man developed a rapidly progressive myelopathy 14 months after blood transfusion and died 1 year the onset of symptoms. Detailed pathologic examination spinal cord was consistent with diagnosis HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although no HTLV-I viral particles, antigens, or nucleic acids were detected in situ, polymerase chain reaction assays revealed proviral DNA cervical, thoracic, lumbar levels cord, greatest amount being at...

Multiple sclerosis is rare among the indigenous black people of Africa. The first account a patient with multiple in South Africa was published as late 1987. Since then search to find patients Southern has continued. Seven have now been traced and five Zimbabwe whom diagnosis can be accepted. Six 12 became blind, or nearly so, from severe optic neuritis. these few more often resembled disorder it occurs oriental than white southern North America Caribbean.

Cerebrovascular disease occurs in HIV-positive individuals, but no relationship between the two has been established. The authors reviewed a cohort of patients aged 15 to 44 years evaluate stroke and negative subjects. Patients who were with other identifiable etiology compared age- race-matched HIV-negative patients. groups did not differ angiographic, cardiac, or serologic tests. A positive HIV test does provide causal information diagnosis.

Unexplained spastic myelopathy in black (Zulu) patients, similar to that seen the tropics, has previously been described from Natal, South Africa. Following reports linking human T cell lymphotropic virus type I (HTLV-I) myelopathy, we undertook a prospective and retrospective search for HTLV-I antibodies 36 patients who were labelled as having unexplained myelopathy; 24 (66%) positive was isolated 4 out of 6 whose peripheral blood lymphocytes cultured. Eighteen (75%) gave short history...

To investigate differences in clinical presentation, electrodiagnostic measures, CSF changes, and treatment outcome measures HIV-infected HIV-uninfected patients with chronic inflammatory demyelinating polyneuropathy (CIDP).A retrospective analysis of medical records all meeting the European Federation Neurology diagnostic criteria for idiopathic CIDP was performed 2 neuromuscular units Kwa-Zulu Natal between 2003 2015.Eighty-four were included study; 39 45 HIV-uninfected. Among patients,...

Abstract Peripheral nerve dysfunction (PND) was found in as many 43% of our patients with human T‐cell lymphotropic virus type I (HTLV‐I)–associated myelopathy (HAM/TSP). To evaluate the PND further we biopsied sural 6 patients. The histological features were varying degrees demyelination, remyelination, axonal atrophy and degeneration, perineurial fibrosis. “Globule” or “sausage” formation prominent two specimens. Inflammatory infiltrates absent. No deposits IgG, IgM, IgA, complement...

Myelopathy due to schistosome infection is a rare, yet probably frequently unrecognized, form of schistosomiasis. This condition clinically difficult diagnose, and without specific biopsy evidence final confirmation relies largely on circumstantial evidence. We describe here immunological attempts diagnose schistosomal myelopathy. ELISA performed the cerebrospinal fluid (CSF) was most successful, detecting 12/12 cases tested prior or within one month treatment. based "normal" value...

Summary: Twenty-five patients with congenital idiopathic clubfoot, aged 1 day to 22 months, were studied electromyographically. No myopathic or neurogenic changes found in tibialis anterior, peroneus, gastrocnemius, extensor digitorum brevis, and abductor hallucis brevis muscles of the leg foot. Maximum motor nerve conduction velocities for peroneal tibial nerves normal. It is concluded that conventional electromyographic techniques unable demonstrate abnormalities suggesting neuropathic clubfoot.

Few data exist on myelopathy associated with Schistosoma mansoni infection. These researchers describe clinical features in 13 patients an inflammatory and either (1) positive S. serology blood, CSF, or both, (2) ova the stool. The presented pain paresthesias back lower limbs, weakness, urinary incontinence, fever. Clinical findings were variable included flaccid areflexic paraplegia, spastic signs suggesting a lumbosacral radiculopathy. Sensory changes consistent …

The authors determined the cause of myelopathies in 33 HIV seropositive individuals KwaZulu/Natal, South Africa. main associations were with human T-cell lymphotrophic virus–I, tuberculosis, herpes zoster, and syphilis. A novel association probable bilharziasis was noted. Only one case vacuolar myelopathy identified. Opportunistic infections will probably persist until routine antiretroviral therapy becomes widely available

We report unusual cases of combined central and peripheral demyelination in two siblings related to pregnancy, each presenting with progressive tetraparesis cranial nerve palsies. The elder sister had a relapsing-remitting course optic dysfunction died during relapse from respiratory insufficiency. younger presented disorientation acute-onset limb facial weakness. She responded well corticosteroid therapy. Their clinical presentation, response immunomodulatory therapy, conduction studies,...

ABSTRACT Objective To define more clearly the neuropathophysiology of eclampsia. Design A prospective study relating to computerised cerebral tomography (CAT) scan and electroencephalogram (EEG) findings in Setting large referral centre a developing society. Subjects Thirty‐two women with Main outcome measures Abnormalities EEG CAT findings. Results Approximately 45% studied had abnormalities, while 90% abnormalities. burst suppression pattern on examination was found four suggesting...

We report a case of Alexander9s disease in black South African boy 9 years. The child presented with grossly abnormal stooped posture, generalised weakness, and slurred nasal speech. Computerised tomography revealed diffuse low radio-density confined to the white matter, enlarged ventricles. Cerebral biopsy confirmed diagnosis. histopathological electron microscopic features are essentially same as those described previous reports. note presence dense clumps material within some Rosenthal...

A case of centronuclear myopathy adult onset with striking hypertrophy lower limb muscles in a black South African man is described details the light microscopic, histochemical, and ultrastructural features. The association hypertrophied has not to our knowledge been reported previously it felt that this may be variant condition.