A5087847975- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Maternal and fetal healthcare
- Reproductive System and Pregnancy
- Global Maternal and Child Health
- Maternal and Perinatal Health Interventions
- Pregnancy and Medication Impact
- HIV/AIDS Research and Interventions
- Gestational Diabetes Research and Management
- Neurological Complications and Syndromes
- Cardiovascular Issues in Pregnancy
- Adolescent Sexual and Reproductive Health
- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Reproductive Health and Contraception
- Syphilis Diagnosis and Treatment
- Cervical Cancer and HPV Research
- COVID-19 Impact on Reproduction
- Hemoglobinopathies and Related Disorders
- Electrolyte and hormonal disorders
- HIV-related health complications and treatments
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Reproductive tract infections research
- Assisted Reproductive Technology and Twin Pregnancy
University of KwaZulu-Natal
2015-2024
University of Zululand
2004-2024
Stellenbosch University
2022
Tygerberg Hospital
2022
University of Pretoria
2022
National Research Foundation
2021
Proteogenomics Research Institute for Systems Medicine
2021
Durban University of Technology
2021
Weatherford College
2021
Women's Health Research Institute
2019
To determine the efficacy and safety of 2 inexpensive easily deliverable antiretroviral (ARV) regimens for prevention mother-to-child transmission (MTCT) human immunodeficiency virus (HIV) type 1 during labor delivery, HIV-infected pregnant women were screened at 11 maternity health institutions in South Africa enrolled an open-label short course ARV regimen either nevirapine (Nvp) or multiple-dose zidovudine lamivudine (Zdv/3TC). The overall estimated HIV-1 infection rates 1307 infants by 8...
We assessed the association between causative agents of vaginal discharge and pelvic inflammatory disease (PID) among women attending a rural sexually transmitted clinic in South Africa; role played by coinfection with human immunodeficiency virus type 1 (HIV-1) was studied. Vaginal cervical specimens were obtained to detect Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, bacterial vaginosis. HIV-1 infection established use serum antibody tests. A total 696 recruited,...
The safety, pharmacokinetics, and antiretroviral activity of lamivudine alone in combination with zidovudine was studied pregnant women infected human immunodeficiency virus type 1 (HIV-1) their neonates. Women received the drugs orally from week 38 pregnancy to after delivery. Neonate therapy began 12 h delivery continued for week. Both treatment regimens were well-tolerated newborns. Lamivudine pharmacokinetics similar those nonpregnant adults. freely crossed placenta secreted breast milk....
Background. In the latest (2011 - 2013) Saving Mothers report, National Committee for Confidential Enquiries into Maternal Deaths in South Africa (SA) (NCCEMD) highlights large number of maternal deaths associated with caesarean section (CS). The risk a woman dying as result CS during past triennium was almost three times that vaginal delivery. Of all mothers who died or after CS, 3.4% procedure and 14.5% from haemorrhage afterwards. Including cases death obstetric where done, there were 5.5...
Preeclampsia (PE) is a complex heterogeneous disorder with overlapping clinical phenotypes that complicate diagnosis and management. Although several pathophysiological mechanisms have been proposed, placental dysfunction due to inadequate remodelling of uterine spiral arteries leading mal-perfusion syncytiotrophoblast stress recognized as the unifying characteristic early-onset PE. Placental overgrowth or premature senescence are probably causes late-onset The frequency PE has increased...
The process of physiological conversion spiral arteries is dependent on the invasion interstitium and uterine wall by invasive extravillous trophoblast thereby creating a high flow-low resistance vessel. Quantitative data restriction failure artery transformation are limited in preeclampsia.This study morphometrically analyzes interstitial cells embedded converted within decidua myometrium normotensive preeclamptic Black African pregnant women.Placental bed biopsies were obtained from 25...
The factors affecting cardiac output in normal pregnancy remain controversial. This study prospectively evaluates maternal central hemodynamics and structure function by echocardiography, together with stature correction correlation of these variables healthy pregnant women the latter half pregnancy.One hundred sixty echocardiographic studies were performed 35 for longitudinal evaluation from early second trimester until term 6-12 weeks postpartum.Cardiac increased significantly at to mid...
Background. The objective of this study was to test the hypothesis that maternal plasma, cord plasma and placental tissue lipid peroxidation products are increased antioxidants decreased in women with pre‐eclampsia. Methods. Placenta, were collected at delivery from 29 normal, 21 pre‐eclamptic six eclamptic women. Plasma non‐pregnant matched controls. analyses measured by HPLC colorimetric assay. Results. concentrations uric acid, LPO, MDA, ascorbic vitamin E cholesterol not significantly...
Objectives: To determine the prevalence of anemia at first antenatal visit and 32–34 weeks gestational age, to evaluate perinatal maternal outcomes.Methods: Venous blood samples were obtained for complete counts both study visits. Maternal morbidity mortality also recorded. The data analyzed using SPSS (version 23).Results: Two thousand pregnant women recruited. was 42.7% (n = 854/2000) visit. Thirty-five percent had mild 68.9% normocytic normochromic anemia. in HIV infected higher than that...
Objective To define more clearly the neuropathophysiology of eclampsia utilising single‐photon emission computed tomography (SPECT), cerebral computerised (CT) and transcranial Doppler (TCD) ultrasonography. Design A prospective study. Setting The obstetric unit in King Edward VIII Hospital, a large tertiary referral centre hi Kwa‐Zulu Natal, South Africa. Participants Sixty‐five women with eclampsia. Interventions Imaging ultrasonographic investigations were performed within 48 hours...
Objective To assess maternal middle cerebral artery flow velocity patterns as measured by transcranial Doppler ultrasound (TCD) in eclampsia and to investigate the effect of anticonvulsants magnesium sulphate (MgSO 4 ) phenytoin on circulation. Design Prospective randomised study. Setting High care obstetric unit, King Edward VIII Hospital, Durban, South Africa. Participants Twenty‐four eclamptic patients: 13 received MgSO, 11 phenytoin. Intervention Middle waveforms were using 2 MH z pulsed...