A5033863612- Down syndrome and intellectual disability research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
Shanghai Jiao Tong University
2021-2023
Shanghai Children's Hospital
2021-2023
Down syndrome (DS) is the most common autosomal aneuploidy caused by trisomy of chromosome 21. Previous studies demonstrated that DS affected mitochondrial functions, which may be associated with abnormal development nervous system in patients DS. Runt-related transcription factor 1 (RUNX1) an encoding gene located on It has been reported RUNX1 affect cell apoptosis via pathway. The present study investigated whether plays a critical role dysfunction and explored mechanism affects functions....
Mental retardation is the main clinical manifestation of Down syndrome (DS), and neural abnormalities occur during early embryonic period continue throughout life. Tc1, a model mouse for DS, carries majority part human chromosome 21 has multiple neuropathy phenotypes similar to patients with DS. To explore mechanism Tc1 mouse, induced pluripotent stem (iPS) cells from mice were obtained, genome-wide gene expression methylation analysis performed wild-type iPS cells. Our results showed...