A5103490595- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Phagocytosis and Immune Regulation
- Brain Metastases and Treatment
- Peptidase Inhibition and Analysis
- Gastrointestinal Tumor Research and Treatment
Wenzhou Medical University
2024
Shanghai Pulmonary Hospital
2024
Tongji University
2024
Zhejiang Cancer Hospital
2014
Brain metastases are one of the leading causes death from non-small-cell lung cancer (NSCLC). The use epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) to treat brain remains controversial. Thus, we performed a pooled analysis published data evaluate efficacy EGFR-TKIs in NSCLC patients with metastases, particularly for tumors activating EGFR mutations.Several sources were searched, including PubMed, Web Science, and ASCO Annual Meetings databases. end points...
ABSTRACT Although adeno-to-squamous transition (AST) has been observed in association with resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) clinic, its causality, molecular mechanism and overcoming strategies remain largely unclear. We here demonstrate that squamous occurs concomitantly TKI PC9-derived xenograft tumors. Perturbation of via DNp63 overexpression or knockdown leads significant changes responses, indicative a direct causal link between...