A5083860961- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Vitamin K Research Studies
- Vitamin C and Antioxidants Research
- Ultrasound in Clinical Applications
- Sepsis Diagnosis and Treatment
- Family and Patient Care in Intensive Care Units
- Blood transfusion and management
- Ion channel regulation and function
- Enhanced Recovery After Surgery
- Thermal Regulation in Medicine
- Anesthesia and Pain Management
- Electrolyte and hormonal disorders
Wellington Hospital
2017-2024
Medical Research Institute of New Zealand
2019-2024
Capital and Coast District Health Board
2019-2020
The Alfred Hospital
2020
It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock. To determine the combination thiamine, compared with alone, improves duration time alive free vasopressor administration patients Multicenter, open-label, randomized clinical trial conducted 10 intensive care units Australia, New Zealand, Brazil that recruited 216 fulfilling Sepsis-3 definition The first patient was enrolled on May 8, 2018, last...
BackgroundThere is limited knowledge about the effect of liberal intraoperative oxygen on non-infectious complications and overall recovery from surgery.MethodsIn this retrospective cohort study, we investigated associations between mean fraction inspired (FiO2), outcome in adults undergoing elective surgery lasting more than 2 h at a large metropolitan New Zealand hospital 2012 to 2020. Patients were divided into low, medium, high groups (FiO2 ≤ 0.4, 0.41–0.59, ≥0.6). The primary was days...
Septic shock is associated with poor outcomes. Vitamin C (ascorbic acid) a cellular antioxidant and has anti-inflammatory properties. Whether the combination therapy of vitamin C, thiamine hydrocortisone reduces vasopressor dependency in septic unclear.To describe protocol statistical analysis plan multicentre, open-label, prospective, phase 2 randomised clinical trial evaluating effects when compared monotherapy on duration administration critically ill patients shock.VITAMINS multicentre...
The practice of anaesthetists relating to the administration intraoperative oxygen has not been previously quantified in Australia and New Zealand. optimal regimen patients undergoing surgery under general anaesthesia is known, international recommendations for therapy are contradictory; World Health Organization (WHO) recommend administering an fraction inspired at least 0.8, while Federation Societies Anaesthesiologists, British Thoracic Society, Society Zealand a more restrictive...
We conducted a survey of Australian and New Zealand anaesthetists designed to quantify self-reported use cricoid pressure (CP) in patients presumed be at risk gastric regurgitation, ascertain the underlying justifications used support individual practice. aimed identify perceived benefits harms associated with CP explore potential impact medicolegal concerns on clinical decision-making. also sought views whether recommendations relating should included airway management guidelines. an...
International recommendations encourage liberal administration of oxygen to patients having surgery under general anaesthesia, ostensibly reduce surgical site infection. However, the optimal regimen minimise postoperative complications and enhance recovery from remains uncertain. The hospital operating theatre randomised (HOT-ROX) trial is a multicentre, patient- assessor-blinded, parallel-group, clinical designed assess effect restricted, standard care, or peri-operative therapy on days...
We conducted a survey of Australian and New Zealand anaesthetists to determine self-reported practice perioperative oxygen administration quantify perceptions regarding the perceived benefits risks resulting from liberal therapy delivered in manner consistent with current World Health Organization guidelines. In addition, we sought feedback on acceptability several proposed clinical trial designs aiming assess overall effect restricted regimens patient outcomes. developed 23-question...
Testing for malignant hyperthermia in New Zealand involves two tests—in vitro contracture testing of excised lateral quadriceps muscle and DNA analysis. In is regarded as the gold standard diagnosis but several publications have questioned reliability a normal result. Analysis 479 anaesthetic records 280 patients or their descendants throughout who had tested negative hyperthermia, demonstrated there was no evidence episodes this group been administered triggering agents. A wide range...