A5103061151- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Sexual function and dysfunction studies
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Polysaccharides Composition and Applications
- Urticaria and Related Conditions
- Ophthalmology and Eye Disorders
- Cancer, Lipids, and Metabolism
- Proteoglycans and glycosaminoglycans research
- Peripheral Nerve Disorders
- Genital Health and Disease
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Glycosylation and Glycoproteins Research
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Multiple and Secondary Primary Cancers
- Migraine and Headache Studies
Czech Academy of Sciences
2020
Czech Academy of Sciences, Institute of Experimental Medicine
2016-2019
Charles University
2016-2017
Ocní klinika
1991
Restoration of lost neuronal function after spinal cord injury (SCI) still remains a big challenge for current medicine. One important repair strategy is bridging the SCI lesion with supportive and stimulatory milieu that would enable axonal rewiring. Injectable extracellular matrix (ECM)-derived hydrogels have been recently reported to neurotrophic potential in vitro. In this study, we evaluated presumed neuroregenerative properties ECM vivo acute model SCI. were prepared by...
Abstract Extracellular matrix (ECM) hydrogels, produced by tissue decellularization are natural injectable materials suitable for neural repair. However, the rapid biodegradation of these may disrupt reconstruction in vivo . The aim this study was to improve stability previously described ECM hydrogel derived from human umbilical cord using genipin and N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC), crosslinking at concentration 0.5–10 mM. crosslinked (ECM/G) or EDC...
Extracellular matrix (ECM) hydrogels prepared by tissue decellularization have been reported as natural injectable materials suitable for neural repair. In this study, we ECM hydrogel derived from human umbilical cord (UC) and evaluated its composition mechanical biological properties in comparison with the previously described porcine urinary bladder (UB), brain, spinal cord. The did not differ each other concentration of collagen, while highest content glycosaminoglycans well shortest...
Chondroitin sulphates belong to a group of naturally occurring glycosaminoglycans and play role in many physiological processes including ageing the effects various diseases. Research into chondroitin has found that most important analytes are 4- 6-sulphated disaccharides. We developed an HPLC method for separation quantification underivatized chondroitin/dermatan sulphates—unsaturated disaccharides (4- disaccharides). This is based on by amido as well amino columns under acidic conditions....