A5063439864- CRISPR and Genetic Engineering
- Polysaccharides and Plant Cell Walls
- Plant Molecular Biology Research
- Advanced biosensing and bioanalysis techniques
- Plant Reproductive Biology
- Viral Infections and Immunology Research
- Innovation and Socioeconomic Development
- RNA and protein synthesis mechanisms
- Telomeres, Telomerase, and Senescence
- Advanced Memory and Neural Computing
State Key Laboratory of Chemobiosensing and Chemometrics
2022-2024
Hunan University
2022-2024
Fujian Agriculture and Forestry University
2017-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021
Chongqing Medical University
2021
Abstract Proteins capable of switching between distinct active states in response to biochemical cues are ideal for sensing and controlling biological processes. Activatable CRISPR‐Cas systems significant precise genetic manipulation sensitive molecular diagnostics, yet directly Cas protein function remains challenging. Herein, we explore anti‐CRISPR (Acr) proteins as modules create synthetic switches (CasPSs) based on computational chemistry‐directed rational interface engineering. Guided...
The physiological functions of epidermal cells are largely determined by their diverse morphologies. Most flowering plants have special conical-shaped petal that thought to influence light capture and reflectance, provide pollinator grips, but the molecular mechanisms controlling conical cell shape remain unknown. Here, we developed a live-confocal imaging approach quantify geometric parameters in Arabidopsis thaliana (A. thaliana). Through genetic screens, identified katanin (KTN1) mutants...
Abstract Proteins capable of switching between distinct active states in response to biochemical cues are ideal for sensing and controlling biological processes. Activatable CRISPR‐Cas systems significant precise genetic manipulation sensitive molecular diagnostics, yet directly Cas protein function remains challenging. Herein, we explore anti‐CRISPR (Acr) proteins as modules create synthetic switches (CasPSs) based on computational chemistry‐directed rational interface engineering. Guided...
Plants have evolved diverse cell types with distinct sizes, shapes, and functions. For example, most flowering plants contain specialized petal conical epidermal cells that are thought to attract pollinators influence light capture reflectance, but the molecular mechanisms controlling shaping remain unclear. Here, through a genetic screen in Arabidopsis thaliana, we demonstrated loss-of-function mutations ANGUSTIFOLIA (AN), which encodes for homolog of mammalian CtBP/BARs, displayed...
Plant cells continuously experience mechanical stress resulting from the cell wall that bears internal turgor pressure. Cortical microtubules align with predicted maximal tensile direction to guide cellulose biosynthesis and therefore results in reinforcement. We have previously identified Increased Petal Growth Anisotropy (IPGA1) as a putative microtubule-associated protein Arabidopsis, but function of IPGA1 remains unclear. Here, using Arabidopsis cotyledon pavement model, we demonstrated...