A5056441543- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Tuberculosis Research and Epidemiology
- Fatty Acid Research and Health
- Fungal Biology and Applications
- Bee Products Chemical Analysis
- Insect Utilization and Effects
- Gut microbiota and health
- Pancreatic function and diabetes
- Pharmacogenetics and Drug Metabolism
- Animal and Plant Science Education
- Glutathione Transferases and Polymorphisms
- Cholesterol and Lipid Metabolism
- Neurological Disorders and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Metabolism, Diabetes, and Cancer
- Medicinal plant effects and applications
- Parasites and Host Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Acid Research Studies
- Alzheimer's disease research and treatments
Kasetsart University
2021-2024
Mahidol Oxford Tropical Medicine Research Unit
2024
Mahidol University
2024
Background and Aim: Hermetia illucens, a black soldier fly, is widely recognized for sustainable recycling of organic waste. Black fly larvae (BSFLs) can consume various types biowastes convert them into nutrient-rich biomass, including proteins, lipids, chitin, minerals. This study investigated the best extraction method by comparing fatty acid profiles, percentage yield, antioxidant properties BSFL oil extracted using different methods. Materials Methods: The physicochemical properties,...
Crocodile oil is a highly effective treatment for ailments ranging from skin conditions to cancer. However, the effects of on liver detoxification pathways are not well studied. This study aimed investigate crocodile enzyme activities and mRNA expressions cytochrome P450 1A2 (CYP1A2), 2E1 (CYP2E1), glutathione S-transferase (GST) in rats. The rats were divided into four groups (n = 7/group): received standard diet (C), high-fat or HFD (H), with 1 ml (HCO1) 3 (HCO3) per kg body weight....
Consumption of fatty acids (FA) can alter hepatic energy metabolism and mitochondrial function in the liver. Crocodile oil (CO) is rich mono-and polyunsaturated FAs, which have natural anti-inflammatory healing properties. In rat livers, we investigated effect CO on for homeostasis. Twenty-one male Sprague-Dawley rats were divided into three groups at random. Group 1 given sterile water (RO), 2 (3% v/w), 3 palm (PO) v/w). For 7 weeks, water, CO, PO orally. The researchers looked body weight,...
Crocodile oil (CO) is rich in monounsaturated fatty acids and polyunsaturated acids. The antioxidant activity cognitive effect of have been largely reported. This work aimed to investigate the CO on function rats. Twenty-one rats were divided into three treatment groups: (1) sterile water (NS), (2) 1 mL/kg (NC1), (3) 3 (NC3). Rats underwent oral gavage once daily for 8 weeks. decreased triglycerides level significantly compared with that NS group. had a free radical scavenging ability...
Type 1 Diabetes mellitus (T1DM) is associated with abnormal liver function, but the exact mechanism unclear. Cordycepin improves hepatic metabolic pathways leading to recovery from damage. We investigated effects of cordycepin in streptozotocin-induced T1DM mice via expression proteins. Twenty-four were divided into four equal groups: normal (N), treated (N+COR), diabetic (DM), and (DM+COR). Mice each treatment group intraperitoneally injection at dose 24 mg/kg for 14 consecutive days. Body...
Dietary fat composition is a potential major factor affecting energy metabolism. Crocodile oil (CO) rich in mono- and poly-unsaturated fatty acids exhibiting anti-inflammatory healing properties.This study investigated different levels of CO consumption on alterations expression proteins involved metabolism rats.Twenty-one male Sprague-Dawley rats were divided into three groups administered sterile water (N) or doses [1% 3% (v/w) CO] orally once daily for 8 weeks. Body weight gain, food...
Cordyceps militaris (CM) is a fungus that has been used to enhance aphrodisiac activity in men, but date, no studies have focused on its antidiabetic properties. This study aimed investigate the effects of CM reproductive performance streptozotocin (STZ)-induced diabetic male rats.Six-week-old Wistar rats were randomly divided into four groups: control Group 1 consisting healthy rats; 2, treated with (100 mg/kg); 3, untreated and 4, mg/kg). Rats orally administered vehicle or for 21 days....
Schistosomiasis, caused by Schistosoma trematodes, is a significant global health concern, particularly affecting millions in Africa and Southeast Asia. Despite efforts to combat it, the rise of praziquantel (PZQ) resistance underscores need for new treatment options. Protein kinases (PKs) are vital cellular signaling offer potential as drug targets. This study focused on focal adhesion kinase (FAK) candidate anti-schistosomal therapy. Transcriptomic proteomic analyses adult S. mekongi worms...
The liver is a key organ governing body energy metabolism. Dietary fats influence metabolism and mitochondrial functioning. Crocodile oil (CO) rich in mono- polyunsaturated fatty acids that contain natural anti-inflammatory healing properties. Our study examined how CO affects the expressions of proteins involved rats. Twenty-one male Sprague Dawley rats were divided into three groups underwent oral gavage with 3 ml/kg sterile water (N group), (CO or palm (PO group) for 7 weeks. Body weight,...
Crocodile oil (CO) is rich in polyunsaturated (PUFAs) fatty acids. Diets PUFAs can maintain mitochondrial function, which important signal transduction and survival of neuronal cells. We investigated the effects CO on brain protein expression cognitive function male rats. Twenty-one rats were randomly divided into three groups: (1) control, (2) treated with (3 mL/kg), (3) palm (PO; 3 mL/kg). Animals received oral gavage once-daily for seven weeks. The parameters that measured food intake,...
Diabetes mellitus (DM) is characterized by metabolic disorders and psychological deficits, including cognitive decline. Here, we investigated the effect of cordycepin on oxidative stress protein expression in brains diabetic mice. Twenty-four mice were divided into four groups, one comprising untreated healthy (N); treated with (24 mg/kg body weight) (N+Cor); DM mice; (DM+Cor). After 14 days treatment, behavior was assessed using novel object recognition (NOR) test. The brain levels markers...
Dietary fat can alter host metabolism and gut microbial composition. Crocodile oil (CO) was extracted from the fatty tissues of Crocodylus siamensis. CO, rich in monounsaturated- polyunsaturated acids, has been reported to reduce inflammation, counter toxification, improve energy metabolism. The aim this study investigate effect CO on microbiota (GM) laboratory mice as well accompanying metabolic changes animals. Forty-five C57BL/6 male were randomly divided into five groups orally...
Importance of the work:Although fat is an essential nutrient, its accumulation associated with chronic diseases in animals and humans.Different types oil differently alter food intake energy expenditure through regulation leptin signaling.Objectives: To investigate effect palm (PO) crocodile (CO) consumption on signaling rats.Materials & Methods: Male Wistar rats (7 rats/group) were divided into control, PO CO groups.The treated oils or water (control) supplied using oral gavage once daily...