A5061414465- Osteoarthritis Treatment and Mechanisms
- Healthcare and Venom Research
- Antimicrobial Peptides and Activities
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Bee Products Chemical Analysis
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Human Health and Disease
- Sexual function and dysfunction studies
- Interpreting and Communication in Healthcare
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Medicinal plant effects and applications
- Menopause: Health Impacts and Treatments
- Pregnancy-related medical research
- COVID-19 and healthcare impacts
- Pelvic floor disorders treatments
- Physical Education and Training Studies
- Healthcare professionals’ stress and burnout
- Protein Hydrolysis and Bioactive Peptides
- Endometriosis Research and Treatment
- linguistics and terminology studies
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
Opća Bolnica Zadar
2023
Institute for Medical Research and Occupational Health
2022
University of Rijeka
2012
Klinički Bolnički Centar Rijeka
2010
Type 2 diabetes mellitus (T2DM) is a multisystemic disease with high global burden and chronic complications. Sexual dysfunction (SD) in patients T2DM an often-overlooked complication, despite its impact on quality of life (QoL). Female sexual disorders can affect women reproductive age as well menopausal women. Proposed mechanisms are intertwining variety physiological, neurological, vascular, hormonal, psychological variables. The impairment function has been linked to hyperglycemia,...
BACKGROUND: COVID-19 presents a threat to the mental health of medical staff working with patients. OBJECTIVE: To investigate impact during pandemic on resident physicians. METHODS: The study was conducted via anonymous online survey and included contained questions about sociodemographic information, general job satisfaction pandemic, their personal lives. RESULTS: This response from 728 majority residents rated that had mostly negative professional life (59.9%) quality work (62.8%), lives...
Osteoarthritis (OA) is a chronic joint disease caused by mechanical damage and metabolic factors that support the development of low-grade inflammation. Increased levels T helper 1 pro-inflammatory cytokines in serum OA patients may granulysin (GNLY) mediated cytotoxicity, which in-turn contribute to pathogenesis OA. In present study, GNLY expression cytotoxic/apoptotic mechanisms peripheral blood were assessed. A total 40 non-obese women (median age 64 years old) with knee OA, controls 62...
Hrvatska liječnička komora brine za postizanje i održavanje stručne osposobljenosti liječnika prema standardima suvremene medicinske znanosti kroz originalne projekte koji su članovima lako dostupni besplatni. U sklopu sufinanciranog projekta EU-a Kontinuirano stručno usavršavanje opće/obiteljske medicine tiskana četiri priručnika te je izrađena edukacijska elektronička platforma na kojoj polaznici mogu pogledati stotinjak predavanja iz različitih područja medicine. Kroz projekt se provode...
<h3>Background</h3> The role of the cell-mediated immune response is recently recognized in osteoarthritis (OA) (1). Granulysin (GNLY) mediator cellular immunity and cytotoxic molecule expressed T NK cells regulatory (15 kDa) (9 forms (2). Cytotoxic 9 kDa form GNLY mediates apoptosis eukaryotic (3) might be responsible for silent unscheduled joint tissue patients with OA without clinically systematic reaction, as measured by erythrocyte sedimentation rate (ESR) C-reactive protein (CRP) (4)....
<h3>Background:</h3> In OA joint, synovial membrane contain immunocompetent cells (1-4), which produce predominantly pro-inflammatory cytokines (2,5), justifying the name "osteoarthritis" and directing development of disease towords mild systemic inflammatory condition (6). Granulysin (GNLY) is mediator cellular immunity expressed in T NK 15 kDa precursor 9 cytotoxic forms (2). It regulated by interleukin 15. We investigated GNLY expression perifperal blood lymphocytes mediated apoptosis...
Background: Macrophages are abundant inflammatory cell type in the synovial membrane of knee osteoarthritis (OA) (1). Their quantity is associated with radiographic severity OA and joint symptoms (2), while their functions set response to micro-environmental signals (3). Classically activated macrophages M1 support T helper 1 (Th1) driven pro-inflammatory reactions, alternatively M2 strengthen Th2 processes Objectives: To investigate activation status tissue patients mature terms /...