A5077013003- Visual perception and processing mechanisms
- Spatial Neglect and Hemispheric Dysfunction
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Color Science and Applications
- Ophthalmology and Visual Impairment Studies
- Hemispheric Asymmetry in Neuroscience
- Virtual Reality Applications and Impacts
- Motor Control and Adaptation
- Multisensory perception and integration
- EEG and Brain-Computer Interfaces
- Death, Funerary Practices, and Mourning
- Sports Performance and Training
- Bioinformatics and Genomic Networks
- Tactile and Sensory Interactions
- Color perception and design
- Neurological Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Vestibular and auditory disorders
- Mind wandering and attention
- Spatial Cognition and Navigation
- Long-Term Effects of COVID-19
- Visual and Cognitive Learning Processes
- Aesthetic Perception and Analysis
- Optical measurement and interference techniques
Brunel University of London
2010-2024
European Bioinformatics Institute
2021-2022
University of Ulster
2017
Altnagelvin Area Hospital
2017
Imperial College London
2004-2010
University of London
2010
University of Surrey
1997-2006
University College London
2003-2006
Wellcome Centre for Human Neuroimaging
2006
Charing Cross Hospital
2003-2005
Apremilast is an orally administered phosphodiesterase-4 inhibitor, currently in phase 2 clinical studies of psoriasis and other chronic inflammatory diseases. The inhibitory effects apremilast on pro-inflammatory responses human primary peripheral blood mononuclear cells (PBMC), polymorphonuclear cells, natural killer (NK) epidermal keratinocytes were explored vitro, a preclinical model psoriasis.Apremilast was tested vitro against endotoxin- superantigen-stimulated PBMC, bacterial peptide...
It has been proposed recently that a deficit in keeping track of spatial locations may contribute to the severity unilateral neglect some right hemisphere stroke patients. However, performance on traditional working memory (SWM) tasks (e.g. Corsi blocks) might be confounded by failure encode leftward locations, rather than true maintaining SWM. Here we introduced new procedures for circumventing this measure SWM capacity neglect. In first experiment, 20 patients (10 with and 10 without...
Abstract Visual neglect after stroke is often associated with a failure to explore contralesional space. Here, we show that guanfacine, noradrenergic agonist modulates dorsolateral prefrontal cortex, improves leftward space exploration in selected right‐hemisphere patients neglect. The positive effects of guanfacine were extended ability maintain attention on task. results suggest neuropharmacological targeting intact frontal areas might be one way enhance cognitive function damage posterior...
Gamma band modulations in neural activity have been proposed to mediate attentional processes. To support a causal link between gamma and selection, we attempt evoke oscillations by 50-Hz subliminal flicker. We find that flicker at target location, before presentation, speeds up enhances detection discrimination. This effect is specific the middle of range because it not evident <35-Hz It requires 300 ms build up, dissipates within 250 offset, shows tendency invert after 500 ms. The results...
The precise function of the supplementary eye field (SEF) is poorly understood. Although electrophysiological and functional imaging studies are important for demonstrating when SEF neurones active, lesion critical to establish functions which essential. Here we report a series investigations performed on an extremely rare individual with highly focal medial frontal cortex. High-resolution structural demonstrated that his was confined region left paracentral sulcus, anatomical locus SEF....
Numerous studies have examined executive function (EF) abilities in cognitively healthy older adults and those living with mild cognitive impairment (MCI) Alzheimer's disease (AD). Currently, there are no standard accepted protocols for testing specific EFs; thus, researchers used their preferred tool, which leads to variability assessments of decline a particular ability across studies. Therefore, is need guidance as the most sensitive tests assessing EF decline. A search current literature...
Exploration of the space around us is a fundamental part human behaviour. When it breaks down there an important opportunity to understand its underlying mechanisms. Here we show that many right-hemisphere patients with left neglect re-explore rightward locations, failing keep track them during search. Importantly, such re-exploration occurred despite leftward stimuli being indistinguishable in peripheral vision, so unlikely result from implicit processing neglected targets. Revisits...
Empirical evidence suggests that levodopa medication used to treat the motor symptoms of Parkinson's disease (PD) may either improve, impair or not affect specific cognitive processes. This led 'dopamine overdose' hypothesis impairs performance on tasks if they recruit fronto-striatal circuits which are yet dopamine-depleted in early PD and as a result leads an excess dopamine. has been supported for various learning including conditional associative learning, reversal classification...
Summary OBJECTIVE We explored the hypothesis that activation of hypothalamo‐pituitary‐adrenal axis is involved in pathogenesis hyperandrogenism polycystic ovary syndrome. PATIENTS Seven women with syndrome (mean age 27.6 ± 1.6 (SEM) years) (hirsutism, oligo/ amenorrhoea and elevated serum testosterone dehydroepiandrosterone sulphate) nine normal female controls 24.6 15 were studied. To exclude anovulation as a confounding factor, four these studied both follicular luteal phase menstrual...
Objective Unilateral neglect is a poststroke disorder that impacts negatively on functional outcome and lacks established, effective treatment. This multicomponent syndrome characterised by directional bias of attention away from contralesional space, together with impairments in several cognitive domains, including sustained spatial working memory. study aimed to test the effects guanfacine, noradrenergic alpha-2A agonist, ameliorating aspects neglect. Methods Thirteen right hemisphere...
It is known that neuroticism impairs cognitive performance mostly in difficult tasks, but not so much easier tasks. One pervasive situation of this type multitasking, which the combination two simple tasks creates a highly demanding dual-task, and consequently high neurotics show higher dual-task costs than low neurotics. However, functional neuroanatomical correlates these additional impairments are unknown. To test for this, we assessed brain activity by means magnetic resonance imaging...
Although binocular disparity and motion parallax are powerful cues for depth, neither, in isolation, can specify information about both object size depth. It has been shown that from be combined to the size, distance of an a scene (Richards, 1985 Journal Optical Society America A2 343 – 349). Experiments reported which natural viewing physical stimuli have used investigate nature depth perception on basis presented separately together at range distances. Observers adjusted relative position...
In three investigations children aged 4–9 years were given a sequence of trials on each which they experienced pairs objects looked the same but felt different (such as full and empty cereal packets) or chocolate bars with coloured wrappers). On trial experimenter chose one items from pair predicted whether themselves, another person doll, would know it was just by seeing it. two investigations, even youngest showed clear evidence discriminating in their knowledge judgments between types...
A bstract : The analysis of saccades offers an opportunity to study a number different cognitive processes, such as visuospatial attention, working memory, and volitional conflict. in patients with hemineglect, who performed visual search task, showed repeated fixations on targets previously discovered, yet they often failed retain the information that particular target had been discovered. High‐resolution structural brain scanning this abnormality was due either lesion right intraparietal...
OBJECTIVE We aimed to investigate the pattern of 24‐hour ACTH and cortisol secretion in pitultary‐dependent Cushing's syndrome evaluate pituitary hypothalamic contributions disease. PATIENTS Five women with disease (mean age 35±5 (SEM) years) five normal female controls 25±2 were studied. DESIGN AND MEASUREMENTS Plasma levels measured every 15 minutes for 24 hours using established IRMA RIA respectively. mean trough levels, pulse number amplitude calculated computer software, programmed...
Visual binding is the process by which brain groups elements belonging to one object, whilst segregating them from other scene elements. A computationally parsimonious mechanism of visual binding-by-synchrony (BBS) hypothesis. According this hypothesis, detectors that respond a single object fire in synchrony, while different objects do not. Current psychophysical and physiological evidence are inconclusive about role BBS integration process. Here we provide computational suggesting system...