A5079834078- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- interferon and immune responses
- Disaster Response and Management
- Malaria Research and Control
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- Extracellular vesicles in disease
- Hepatitis B Virus Studies
- Climate Change and Health Impacts
- Liver Disease Diagnosis and Treatment
- Electrochemical Analysis and Applications
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Electrochemical sensors and biosensors
- vaccines and immunoinformatics approaches
- SARS-CoV-2 detection and testing
- Insect Resistance and Genetics
- Vector-Borne Animal Diseases
- Bacillus and Francisella bacterial research
- Fire effects on ecosystems
University of Nottingham
2020-2025
Leeds Beckett University
2015-2025
Loughborough University
2022
Liverpool School of Tropical Medicine
2015
Pyrethroid insecticides are the front line vector control tools used in bed nets to reduce malaria transmission and its burden. However, resistance major vectors such as Anopheles arabiensis is posing a serious challenge success of control. Herein, we elucidated molecular biochemical basis pyrethroid knockdown resistance-free population from Chad, Central Africa. Using heterologous expression P450s Escherichia coli coupled with metabolism assays established that over-expressed P450 CYP6P4,...
Autophagy can defend against infection by delivering viruses to lysosomes for degradation. Semliki Forest virus (SFV) is a positive-sense, single-stranded RNA of the alphavirus genus which has been used extensively as model arbovirus and neuronal encephalitis. Here, we show that autophagy suppressed during early hours SFV neurons. We also switch between suppression upregulation later stages was mediated through modulation mammalian target rapamycin (mTOR) activity infection. At infection,...
Nephropathia Epidemica (NE), endemic to several Volga regions of Russia, including the Republic Tatarstan (RT) and Mordovia (RM), is a mild form hemorrhagic fever with renal syndrome caused by infection rodent-borne orthohantaviruses. Although NE cases have been reported for decades, little known about hantavirus strains associated human in these regions. There also limited understanding pathogenesis RT RM. To address knowledge gaps, we conducted comparative analyses patients Clinical...
Early indications of the likelihood severe coronavirus disease 2019 COVID-19 can influence treatments and could improve clinical outcomes. However, knowledge on prediction markers fatality risks remains limited. Here, we analyzed quantified reactivity serum samples from acute (non-fatal fatal) convalescent patients with spike surface glycoprotein (S protein) nucleocapsid phosphoprotein (N SARS-CoV-2 peptide libraries. Cytokine activation was also analyzed. We demonstrated that IgM fatal...
Identifying immunogenic targets of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is critical to advance diagnostic and disease control strategies. We analyzed humoral (ELISA) T-cell (ELISpot) immune responses spike (S) nucleocapsid (N) SARS-CoV-2 proteins as well human endemic coronavirus (eCoV) peptides in serum from convalescent 2019 (COVID-19) patients Tatarstan, Russia. identified multiple that were reactive with antibodies T cells COVID-19. In addition, age gender...
In the absence of effective vaccines and treatments, annual outbreaks severe human haemorrhagic fever caused by arenaviruses, such as Lassa virus, continue to pose a significant health threat. Understanding balance cellular factors that inhibit or promote arenavirus infection may have important implications for development antiviral strategies. Here, we identified cell-intrinsic zinc transmembrane metalloprotease, ZMPSTE24, restriction factor against arenaviruses. Notably,...
Nephropathia epidemica (NE), caused by the hantavirus infection, is endemic in Tatarstan Russia. The majority of patients are adults, with infection rarely diagnosed children. This limited number pediatric NE cases means there an inadequate understanding disease pathogenesis this age category. Here, we have analyzed clinical and laboratory data adults children to establish whether how severity differs between two groups. Serum cytokines were samples collected from 11 129 adult during...
Nephropathis epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS), is an acute zoonotic disease endemic in the Republic Tatarstan. This study aimed to assess impact rosuvastatin on clinical and laboratory results NE. A total 61 NE patients 30 controls were included this study; 22 7 received daily dose (10 mg) for ten consecutive days. Serum samples collected days 1, 5, 10 after admission hospital. These analyzed determine levels lipids, cytokines, kidney toxicity...
Abstract In the absence of effective vaccines and treatments, annual outbreaks severe human haemorrhagic fever caused by arenaviruses, such as Lassa virus, continue to pose a significant health threat. Understanding balance cellular factors that inhibit or promote arenavirus infection may have important implications for development antiviral strategies. Here, we identified cell-intrinsic zinc transmembrane metalloprotease, ZMPSTE24, restriction factor against arenaviruses. Notably,...
Arenaviruses are the largest family of viral haemorrhagic fever causing viruses. They have worldwide distribution and divided into Old World (OW) New (NW) viruses based on their phylogeny, geographical serological cross-reactivity. Endemic to West Africa South America, these emerging RNA jump species barrier from natural rodent hosts humans, resulting in illnesses ranging mild flu-like syndromes severe highly fatal zoonoses. Recent increased frequency outbreaks associated high fatality rates...