A5078441507- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Algal biology and biofuel production
- Inflammatory mediators and NSAID effects
- stochastic dynamics and bifurcation
- Histone Deacetylase Inhibitors Research
- Nanoplatforms for cancer theranostics
- Heart Rate Variability and Autonomic Control
- Renin-Angiotensin System Studies
- RNA Research and Splicing
- Cardiovascular Health and Disease Prevention
- Light effects on plants
- PI3K/AKT/mTOR signaling in cancer
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Inhalation and Respiratory Drug Delivery
- Angiogenesis and VEGF in Cancer
- Neuroscience and Neural Engineering
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Caveolin-1 and cellular processes
- Lipid metabolism and biosynthesis
- Skin Protection and Aging
- Enzyme Catalysis and Immobilization
Yale University
2018-2024
University of Monterrey
2022
VA Connecticut Healthcare System
2018
Center for Research and Advanced Studies of the National Polytechnic Institute
2011-2016
Instituto Politécnico Nacional
2015-2016
Blood vessels are continually exposed to circulating lipids and elevations of ApoB containing lipoproteins cause atherosclerosis. Lipoprotein metabolism is highly regulated by lipolysis, largely at the level capillary endothelium lining metabolically active tissues. How large blood vessels, site atherosclerotic vascular disease, regulate flux fatty acids (FA) into triglyceride (TG) rich lipid droplets (LD) not known. In this study, we showed that deletion enzyme, adipose lipase (ATGL) in...
Vascular smooth muscle cell (VSMC) phenotypic switching contributes to cardiovascular diseases. Epigenetic regulation is emerging as a key regulatory mechanism, with the methylcytosine dioxygenase TET2 acting master regulator of phenotype. The histone acetyl-transferases p300 and CREB-binding protein (CBP) are highly homologous often considered be interchangeable, their roles in not known.
Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis initiation and progression
Obesity is involved in several cardiovascular diseases including coronary artery disease and endothelial dysfunction. Endothelial Endothelium vasodilator vasoconstrictor agonists play a key role regulation of vascular tone. In this study, we evaluated response an 8 weeks diet-induced obese C57BL/6 mice model. Coronary perfusion pressure to acetylcholine isolated hearts from showed increased vasoconstriction reduced vasodilation responses compared with control mice. Vascular nitric oxide...
Objective— The importance of PI3K/Akt signaling in the vasculature has been demonstrated several models, as global loss Akt1 results impaired postnatal ischemia- and VEGF-induced angiogenesis. ubiquitous expression Akt1, however, raises possibility cell-type–dependent Akt1-driven actions, thereby necessitating tissue-specific characterization. Approach Results— Herein, we used an inducible, endothelial-specific Akt1-deleted adult mouse model (Akt1iECKO) to characterize endothelial cell...