Shifan Wang

ORCID: 0000-0003-0640-0016
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About
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Research Areas
  • Plant Virus Research Studies
  • Mosquito-borne diseases and control
  • Viral Infections and Vectors
  • Genetics and Neurodevelopmental Disorders
  • T-cell and Retrovirus Studies
  • Alzheimer's disease research and treatments
  • Plant Molecular Biology Research
  • Toxoplasma gondii Research Studies
  • Genomics, phytochemicals, and oxidative stress
  • Genetic and Environmental Crop Studies
  • Autophagy in Disease and Therapy
  • Insect symbiosis and bacterial influences
  • Insect-Plant Interactions and Control
  • RNA Research and Splicing

Ningxia Medical University
2024

Harvard University
2022-2024

University of Chinese Academy of Sciences
2020-2022

Chinese Academy of Sciences
2020-2022

Institute of Zoology
2020-2022

Institute of Zoology
2021

Abstract Apoptosis and autophagy are two common forms of programmed cell death (PCD) used by host organisms to fight against virus infection. PCD in arthropod vectors can be manipulated arboviruses, leading arbovirus-vector coexistence, although the underlying mechanism is largely unknown. In this study, we find that coat protein (CP) an insect-borne plant TYLCV directly interacts with a phosphatidylethanolamine-binding (PEBP) its vector whitefly downregulate MAPK signaling cascade. As...

10.1038/s41467-022-28500-8 article EN cc-by Nature Communications 2022-02-11

The mechanism by which plant viruses manipulate the behavior of insect vectors has largely been described as indirect manipulation through modifications host plant. However, little is known about direct interaction virus on nervous system its vector, and substantial behavioral effect transmission. Using a consisting Tomato yellow leaf curl (TYLCV) vector whitefly, we found that TYLCV caused caspase-dependent apoptotic neurodegeneration with severe vacuolar neuropathological lesions in brain...

10.7554/elife.56168 article EN cc-by eLife 2020-07-30

Abstract Transgenerational phenotypic plasticity (TPP) refers to the phenomenon that environmental conditions experienced by one generation can influence phenotype of subsequent generations adapt environment without modification their DNA sequences. Aphid wing dimorphism is a textbook example TPP which maternal aphid perceives cues decide morph her offspring. However, signaling mechanism from mother daughter remains unclear. In this study, we showed population density and physical contact...

10.1101/2024.05.22.595290 preprint EN mit bioRxiv (Cold Spring Harbor Laboratory) 2024-05-26

Abstract Apoptosis and autophagy are two most prominent forms of programmed cell deaths (PCD) that have been implicated in antiviral immunity vertebrate plant hosts. Arboviruses able to coexist with its arthropod vectors by coordinating the PCD immunity, but regulatory mechanism involved is largely unknown. We found coat protein (CP) an insect-borne virus TYLCV directly interacted a phosphatidylethanolamine-binding (PEBP) insect vector whitefly negatively influence MAPK signaling cascade. As...

10.1101/2021.01.19.427364 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2021-01-20
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