A5103129778- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Immune cells in cancer
- Helicobacter pylori-related gastroenterology studies
- Inflammasome and immune disorders
- vaccines and immunoinformatics approaches
- Phytochemistry and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Center of Molecular Immunology (Cuba)
2009-2020
Universidad Nacional Autónoma de México
2018
IL-2 has been used for the treatment of melanoma and renal cell carcinoma, but this therapy limited efficacy severe toxicity. Currently, it is assumed that part due to IL-2-driven preferential expansion regulatory T cells, which dampen antitumor immunity. In study, we characterize a human mutant with higher lower toxicity than wild type (wtIL-2). The differs from wtIL-2 by four mutations at interface α subunit IL-2R. induces in vitro proliferation CD8(+)CD44(hi) NK1.1 cells as efficiently...
Abstract IL-2 is critical for peripheral tolerance mediated by regulatory T (Treg) cells, which represent an obstacle effective cancer immunotherapy. Although important effector (E) cell function, it has been hypothesized that therapies blocking signals weaken Treg activity, promoting immune responses. This hypothesis partially tested using anti–IL-2 or anti–IL-2R Abs with antitumor effects cannot be exclusively attributed to lack of signaling in vivo. In this work, we pursued alternative...
Abstract Several reports in the literature have drawn a complex picture of effect treatments aiming to modulate IL2 activity vivo. They seem promote indistinctly immunity or tolerance, probably depending on specific context, dose and timing their application. Such complexity might derives from dual role T-cell dynamics. To theoretically address latter possibility, we develop mathematical model for helper, regulatory memory T-cells dynamics, which account most well-known facts relative...
Gastric ulcers are a worldwide health problem and their poor healing is one of the most important causes for recurrence. We have previously reported remarkable gastroprotective anti-Helicobacter pylori activities methanolic extract (CpMet) Cyrtocarpa procera bark. This work investigates, in murine model, CpMet mechanism establishes its preclinical efficacy resolution ethanol-induced gastric ulcers. The results showed that activity mainly associated with endogenous NO prostaglandins, followed...
Interleukin-2 (IL2) is a growth factor for several immune cells and its function depends on binding to IL2Rs in the cell membrane. The most accepted model assembling of IL2-IL2R complexes membrane Affinity Conversion Model (ACM). This postulates that IL2R receptor association sequential dependent ligand binding. Most likely free IL2 binds first IL2Rα, then this complex IL2Rβ, finally IL2Rγ (γc). However, previous mathematical models representing process, γc has not been taken into account....
Abstract Activation of T cells triggers the expression regulatory molecules like programmed cell death 1 (PD1) protein. The association PD1 with natural ligands PDL1 and PDL2 induces an inhibitory signal that prevents from proliferating exerting effector functions. However, little is known about how binding induce over Here, we explore dynamics free, in complex different variants as well therapeutic antibodies nivolumab pembrolizumab order to assess conformational changes related signaling...
ABSTRACT Neutrophils and macrophages related processes have been described as relevant during the inflammation resolution after an acute damage. Nevertheless, understanding impact of both cells in which they are involved is still open debate. Specifically, several studies focused on elucidate their dynamic outcome vs uncontrolled response. In this work, we develop a mathematical model that describe innate immune response Our includes all mediate response, including regulatory mechanisms...