A5101801599- Nanopore and Nanochannel Transport Studies
- Microfluidic and Capillary Electrophoresis Applications
- Fuel Cells and Related Materials
- Electrospun Nanofibers in Biomedical Applications
- Clay minerals and soil interactions
- Ion-surface interactions and analysis
- Advanced biosensing and bioanalysis techniques
- Electrostatics and Colloid Interactions
- Microfluidic and Bio-sensing Technologies
- Polymer Surface Interaction Studies
- Membrane-based Ion Separation Techniques
- Soil and Unsaturated Flow
- Lipid Membrane Structure and Behavior
- Bone Tissue Engineering Materials
- Ion channel regulation and function
- Material Dynamics and Properties
- Analytical Chemistry and Sensors
- Hydrogels: synthesis, properties, applications
- Education, sociology, and vocational training
- Silk-based biomaterials and applications
- Graphene and Nanomaterials Applications
- Force Microscopy Techniques and Applications
- Educational Tools and Methods
- Layered Double Hydroxides Synthesis and Applications
- Groundwater flow and contamination studies
Centre National de la Recherche Scientifique
2013-2024
Université de Montpellier
2012-2024
Institut Européen des Membranes
2014-2024
École Nationale Supérieure de Chimie de Montpellier
2006-2021
Institut de Chimie
2008-2019
Institut Charles Gerhardt Montpellier
2008-2019
University of Geneva
2011
For the past 2 decades, emerging single-nanopore technologies have opened route to multiple sensing applications. Besides DNA sensing, identification of proteins and amyloids is a promising field for early diagnosis. However, influence interactions between nanopore surface should be taken into account. In this work, we selected three (avidin, lysozyme, IgG) that exhibit different affinities with SiNx surface, also examined lysozyme amyloid. Our results show piranha treatment significantly...
We report the formation of a hybrid biological/artificial nanopore by direct insertion non-modified α-hemolysin at entrance high aspect ratio (length/diameter) biomimetic nanopore. In this robust system, protein exhibits same polynucleotide discrimination properties as in biological membrane and dwell time is strongly increased. This very promising for DNA sequencing applications where translocation velocity fragility support are main bottlenecks.
Fundamental understanding of ionic transport at the nanoscale is essential for developing biosensors based on nanopore technology and new generation high-performance nanofiltration membranes separation purification applications. We study here through single putatively neutral hydrophobic nanopores with high aspect ratio (of length L = 6 μm diameters ranging from 1 to 10 nm) a well controlled cylindrical geometry. develop detailed hybrid mesoscopic theoretical approach electrolyte...
The aim of this study was to synthesize stable gelatin electrospun mats (ESMs) (cross-linked by glutaraldehyde (GTA) vapors) with tunable drug release properties using pH as a stimulus.
Nanopores are powerful tools for single-molecule sensing of biomolecules and nanoparticles. The signal coming from the molecule to be analyzed strongly depends on its interaction with narrower section nanopore (constriction) that may tailored increase accuracy. Modifications constriction have also been commonly used induce electroosmosis, favors capture molecules in under a voltage bias independently their charge. However, engineering nanopores increasing both electroosmosis accuracy is...
A hybrid nanoporous membrane made of a solid-state polymeric thin film in which an ion channel is confined realized. The primary and extremely encouraging results obtained by confocal fluorescence spectroscopy diffusion measurement demonstrate respectively that (i) the considered channel, is, Gramicidin-A, can be selectively inside nanopores (ii) ionic permeability enhanced. Atomistic molecular simulations are also reported fruitfully compared to experimental findings.
The confinement of lysozyme in 3 layered materials based on montmorillonite and lamellar double hydroxides exhibiting different surface charges was studied. protein structure orientation these were determined by X-ray diffraction, time resolved fluorescence anisotropy. For exchanged with sodium modified a non-ionic surfactant (tri-ethylene glycol mono n-decyl ether), the found to be located interlayer space "end-on" "side-on" orientations, respectively. Conversely, no intercalation observed...
The confinement and the understanding of ion transport through ionic channels when they are confined inside solid-state nanopores smaller than 10 nm remains a challenge. Here we report on fabrication biomimetic with high length (5 μm)/diameter (smaller nm) ratio obtained using both track-etched technique atomic layer deposition flexible membranes. These membranes present uniform hydrophobic low roughness pores. Gramicidin A is then (diameter 10.6, 5.7, ∼2 leading to NaCl mechanism hybrid...
The development of nanometric Coulter counters for nanoparticle detection is an attractive and promising field research. In this work, we have studied the influence nanopore surface state on charged polymer translocations. To make this, translocation carboxylate modified polystyrene microspheres (diameter 40, 70 100 nm) has been investigated through two kinds high aspect ratio nanopores (negative uncharged). latter were tailored by a single track-etched atomic layer deposition technique. It...
2D graphene oxide (GO) is used to enhance the mechanical properties of gelatin electrospun fibers. The GO does not show any significant influence on cell viability and attachment even though expression osteoblast gene affected.
Specific separations of protons and cations are usually performed by electromembrane processes, which require external electric energy. An easier process would be using a membrane able to separate both entities passive diffusion. Presently, such synthetic nanoporous membranes do not exist. Here, we report the production robust hybrid biological/artificial solid-state membrane, allows selective permeation alkali metal without competing or concurrent protons. This is simple prepare based on...
The fundamental understanding of the transport mechanisms objects across a single nanopore is one key point to develop Coulter counters at nanoscale for macromolecule or nanoparticle detection. In this area, nanoparticles have been less investigated than biomacromolecules such as DNA proteins due their self-aggregation in presence salts. work, modified latex solid-state nanopores was investigated. To prevent aggregation, surface with low molecular weight strand coating. Then coated were...
Abstract Electrospinning is a versatile technique to produce micron or nano sized fibers using synthetic bio polymers. The unique structural characteristic of the electrospun mats (ESM) which mimics extracellular matrix (ECM) found influential in regenerative tissue engineering application. ESM with different morphologies functionalizing specific growth factors creates favorable microenvironment for stem cell attachment, proliferation and differentiation. Fiber size, alignment mechanical...
3-Hydroxyflavone (3-OHF) was incorporated in zeolite micropores by ship-in-a-bottle synthesis. This strategy consists of constructing the molecule reaction small precursors within cavity. 3-OHF molecules exhibit excited-state intramolecular proton transfer (ESIPT) and a tautomeric equilibrium between 3-OHF-excited structures N* T*exists. is strongly affected protic nature polarity surrounding medium. The textural spectroscopic characterization dye-loaded colloids enabled study correlation...