A5017683923- Herpesvirus Infections and Treatments
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Poxvirus research and outbreaks
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Hepatitis Viruses Studies and Epidemiology
- Vaccine Coverage and Hesitancy
- Retinal and Optic Conditions
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
Green Cross (South Korea)
2022
Ewha Womans University
2022
Yonsei University
2011-2013
Hepatitis B virus (HBV) synthesizes its DNA genome through reverse transcription, which is catalyzed by viral polymerase (Pol). Previous studies suggested that the RNase H domain of hepadnaviral Pol may contribute to multiple steps replication, such as RNA encapsidation and synthesis. However, specific residues transcription have not been determined. Therefore, we employed charged-to-alanine scanning mutagenesis generate a set single-substitution mutants then analyzed their ability support...
Hepatitis B virus (HBV) replicates its DNA genome via reverse transcription. Precise roles of the terminal protein domain HBV polymerase remain unknown. To gain insight, we created alanine substitution mutations at hydrophobic residues (i.e., tyrosine, tryptophan, and isoleucine), then examined extent by which these mutants carry out viral replication. Evidence indicated that three W74, Y147, Y173) contribute to distinct steps replication: former two are important for synthesis, while latter...
Hepadnaviruses, including human hepatitis B virus (HBV) and duck (DHBV), replicate their DNA genome through reverse transcription. Although hepadnaviral polymerase (Pol) is distantly related to retroviral transcriptases, some of its features are distinct. In particular, in addition the transcriptase RNase H domains, which commonly encoded by N-terminally extended terminal protein (TP) domain confers unique such as protein-priming capability. Importantly, TP also essential for encapsidation...
The currently used Japanese Oka and Korean MAV/06-attenuated varicella vaccine strains belong to clade 2 genotype varicella–zoster viruses (VZV). More than seven clades of VZV exist worldwide. In this study, we investigated the cross-reactivity antibodies induced by vaccines against belonging 1, 2, 3, 5 using a fluorescent antibody membrane antigen (FAMA) test. Among 59 donors, 29 were vaccinated with MAV/06 strain MG1111 (GC Biopharma, South Korea) other 30 VARIVAX (Merck, USA). sera...
Varicella-zoster virus (VZV) is a pathogen that causes chickenpox and shingles in humans. Different types of the varicella vaccines derived from Oka MAV/06 strains are commercially available worldwide. Although vaccine was introduced 1990s, little known about immunological characteristics.Here, we evaluated B T cell immune response animals inoculated with as well new formulation vaccine. A variety test methods were applied to evaluate response. Plaque reduction neutralization (PRNT)...
Abstract Background: Varicella-zoster virus (VZV) is a pathogen that causes chickenpox and shingles in humans. Different types of the varicella vaccines derived from Oka MAV/06 strains are commercially available worldwide. Although vaccine was introduced 1990s, little known about immunological characteristics. Results: Here, we evaluated B T cell immune response animals inoculated with as well new formulation vaccine. A variety test methods were applied to evaluate response. Plaque reduction...