A5106941582- Computational Drug Discovery Methods
- Synthesis and biological activity
- Anesthesia and Pain Management
- Click Chemistry and Applications
- Nausea and vomiting management
- Mosquito-borne diseases and control
- Protein Interaction Studies and Fluorescence Analysis
- Nanoparticles: synthesis and applications
- Ionic liquids properties and applications
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- SARS-CoV-2 and COVID-19 Research
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- HIV Research and Treatment
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- PARP inhibition in cancer therapy
- HIV/AIDS drug development and treatment
- Lipid Membrane Structure and Behavior
- Synthesis and Characterization of Heterocyclic Compounds
- Pain Management and Opioid Use
- Plant Virus Research Studies
- Drug Transport and Resistance Mechanisms
- Spectroscopy and Quantum Chemical Studies
University of Delhi
2017-2025
All India Institute of Medical Sciences Jodhpur
2018-2025
National Institute of Plant Genome Research
2013-2023
Sant Longowal Institute of Engineering and Technology
2023
Jawaharlal Nehru University
2022
SRM Institute of Science and Technology
2022
Deen Dayal Upadhyay Hospital
2020-2021
North-West University
2020
Sanata Dharma University
2020
Babasaheb Bhimrao Ambedkar University
2020
The availability of well-validated informative co-dominant microsatellite markers and saturated genetic linkage map has been limited in foxtail millet (Setaria italica L.). In view this, we conducted a genome-wide analysis identified 28 342 repeat-motifs spanning 405.3 Mb genome. trinucleotide repeats (∼48%) was prevalent when compared with dinucleotide (∼46%). Of the microsatellites, 21 294 (∼75%) primer pairs were successfully designed, total 15 573 physically mapped on 9 chromosomes...
The current outbreak of a novel coronavirus, named as SARS-CoV-2 causing COVID-19 occurred in 2019, is dire need finding potential therapeutic agents. Recently, ongoing viral epidemic due to coronavirus (SARS-CoV-2) primarily affected mainland China that now threatened spread populations most countries the world. In spite this, there currently no antiviral drug/ vaccine available against infection, COVID-19. present study, computer-aided drug design-based screening find out promising...
Abstract Numerous chemical pesticides were employed for a long time to manage pests, but their uncontrolled application harmed the health and environment. Accurately quantifying pesticide residues is essential risk evaluation regulatory purposes. analytical methods have been developed utilized achieve sensitive specific detection of in intricate sampl es like water, soil, food, air. Electrochemical sensors based on amperometry, potentiometry, or impedance spectroscopy offer portable, rapid,...
This work lies in the growing concern over potential impacts of pesticides on human health and environment. Pesticides are extensively used to protect crops control pests, but their interaction with essential biomolecules like haemoglobin (Hb) remains poorly understood. Spectrofluorometric, electrochemical, silico investigations have been chosen as methods delve into this issue, they offer valuable insights molecular-level interactions between haemoglobin. The research aims address gaps...
Background: Work-related musculoskeletal disorders (WMSDs) are a significant global occupational health issue, affecting workers across all industries, including automobile manufacturing. Employees in this sector face high risks of WMSDs, which can severely impact their physical and mental well-being. Objective: The objective study is to determine the prevalence wrist hand pain workers. Method: Articles were chosen from multiple platforms like Google Scholar, PubMed, SCISPACE, ScienceDirect,...
Microglia plays an essential role in regulating brain-specific immunity. Upregulation of microglia-specific proteins, such as ionized Ca+2 binding adaptor-1 (IBA1), colony-stimulating factor 1 receptor (CSF1R), cluster differentiation 40 ligand (CD40L), and purinergic P2Y12 (P2RY12) is central driving neuroinflammation-mediated neurodegeneration poses them potential targets for drug discovery. Few studies have shown seaweed's anti-inflammatory neuroprotective effects, indicating their the...
Abstract Understanding the intricate interplay between proteins and ligands is pivotal for rational drug development. This study investigates binding of Ofloxacin to Hb using diverse biophysical techniques: fluorescence spectroscopy, UV‐visible molecular docking, dynamics simulations, electrochemical analysis. Spectrophotometric data confirm a static quenching mechanism in ofloxacin‐Hb binding. Notably, exhibits significant change free energy (−17.134 kJ/mol) strong affinity via docking was...
The widespread use of pesticides poses significant threats to both environmental and human health, primarily due their potential toxic effects. study investigated the cardiovascular toxicity selected pesticides, focusing on interactions with Toll-like receptor 4 (TLR4), an important part innate immune system. Using computational tools such as molecular docking, dynamics (MD) simulations, principal component analysis (PCA), density functional theory (DFT) calculations, ADME analysis, this...
The rapid growth of industrialisation has led to the discharge harmful effluents into water bodies, severely disrupting balance ecosystems. detection and removal dyes from wastewater remains a significant challenge. In this study, we report synthesis zinc oxide (ZnO) its doped derivatives through facile chemical method, followed by comprehensive characterisation analysis assess their potential in various applications. structural properties synthesised materials were confirmed X-ray...
Abstract Background and Aims: Analgesic efficacy safety of continuous catheter technique in transmuscular quadratus lumborum block (QLB3) for laparoscopic nephrectomy has not been studied. This study was planned to evaluate the ultrasound (US)-guided QLB3 postoperative analgesia after nephrectomy. Material Methods: In this randomized, open-label, single-centered trial, 64 patients belonging American Society Anesthesiologists, physical status grade I II, 18–65 years age, scheduled were...
Abstract Selective docking is a novel concept for drug designing and currently used to find potential inhibitors against non‐structural polyprotein (nsP2) of the chikungunya virus (CHIKV). Herein, authors designed library 200 molecules based on pyranooxazoles virtual screening, docking, isothermally non‐isothermally MD simulations free energy calculations get candidates. The computational strategy significant promising inhibitor this infection. Molecular approach employed conformation in...