A5031577912- Advanced Cellulose Research Studies
- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Mitochondrial Function and Pathology
- Polysaccharides and Plant Cell Walls
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Metabolomics and Mass Spectrometry Studies
- Ubiquitin and proteasome pathways
- ATP Synthase and ATPases Research
- Carbohydrate Chemistry and Synthesis
- DNA Repair Mechanisms
- Enzyme Structure and Function
- Cancer-related gene regulation
- Fungal and yeast genetics research
- Renal and related cancers
- Proteoglycans and glycosaminoglycans research
Johns Hopkins Medicine
2020-2023
Johns Hopkins University
2020-2023
University of Virginia
2012-2016
Novartis (United States)
2016
Tumors put in a vulnerable position Cancer cells often display alterations metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by creating new vulnerabilities can be exploited therapeutically. A variety of human tumors show changes methionine caused loss gene coding for 5-methylthioadenosine phosphorylase (MTAP). Mavrakis et al. and Kryukov found MTAP renders cell lines sensitive to growth inhibition compounds suppress activity...
Formation of solid-phase protein aggregates in mitochondria is associated with mitochondrial lipid metabolism.
Abstract Metabolic genes are increasingly recognized as targets of somatic genetic alteration in human cancer often leading to profound changes intracellular metabolite concentrations. 5-Methylthioadenosine Phosphorylase (MTAP) is a key enzyme the methionine salvage pathway that metabolizes methylthioadenosine (MTA) adenine and methionine. Its chromosomal position proximal CDKN2A results frequent collateral homozygous deletion wide range cancers. By interrogating data from large scale...
Abstract Mitochondria contain a local genome (mtDNA) comprising small number of genes necessary for respiration, mitochondrial transcription and translation, other vital functions. Various stressors can destabilize mtDNA leading to loss. While some cells survive loss, they exhibit various deficiencies. Here, we investigated the impact proteotoxicity on function by inducing unfolded protein stress in budding yeast. This led rapid but aerobic conditioning imparted transient resistance stress....