A5103137931- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Diagnosis and treatment of tuberculosis
- Healthcare Systems and Reforms
- SARS-CoV-2 detection and testing
- Vitamin D Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diverse Scientific Research Studies
- COVID-19 Pandemic Impacts
- Blood transfusion and management
- Diabetes Management and Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Tryptophan and brain disorders
- COVID-19 diagnosis using AI
- Hematological disorders and diagnostics
- Lung Cancer Treatments and Mutations
- vaccines and immunoinformatics approaches
Brihanmumbai Municipal Corporation
2016-2025
Public Health Department
2016-2025
Maharashtra State Board of Technical Education
2025
McMaster University
2023
AIDS Society of India
2018-2022
B.J. Medical College
2022
Topiwala National Medical College & BYL Nair Charitable Hospital
2022
King Edward Memorial Hospital and Seth G.S. Medical College
2022
Abdul Wali Khan University Mardan
2020
Banaras Hindu University
2015-2019
Abstract Background Treatment success rates for multidrug-resistant tuberculosis (MDR-TB) remain low globally. Availability of newer drugs has given scope to develop regimens that can be patient-friendly, less toxic, with improved outcomes. We proposed determine the effectiveness an entirely oral, short-course regimen bedaquiline and delamanid in treating MDR-TB additional resistance fluoroquinolones (MDR-TBFQ+) or second-line injectable (MDR-TBSLI+). Methods prospectively determined safety...
Objective Estimate seroprevalence in representative samples from slum and non-slum communities Mumbai, India, a mega-city low or middle-income country test if prevalence is different slums. Design After geographically-spaced community sampling of households, one individual per household was tested for IgG antibodies to SARS-CoV-2 N-protein two-week interval. Setting Slum three wards, each the main zones Mumbai. Participants Individuals over age 12 who consent have no contraindications...
ABSTRACT Background: Microbiological diagnosis of pediatric pulmonary and intestinal tuberculosis remains difficult due to difficulty in specimen collection such as with sputum, gastric aspirates or biopsies. Stool Xpert MTB/Rif may be useful is non-invasive. Objectives: To determine the sensitivity specificity for Indian children. Methods: We retrospectively compared performance stool Xpert, sample (gastric lavage, bronchoalveolar lavage), Mycobacteria Growth Indicator Tube (MGIT) 52...
Antibodies play a role in herd immunity, and studies estimate that COVID-19 antibody protection lasts approximately 1 to 4 months following vaccination 6 8 infection. As healthcare workers frontline were highly exposed the infection, it is necessary know if they have developed immunity against COVID-19. To seroprevalence of SARS-CoV-2 antibodies among health care Mumbai qualitatively quantitatively observe change levels after months. This longitudinal study was conducted over 9 two phases...
Background There are few rigorous studies comparing quality of tuberculosis (TB) care in public versus private sectors. Methods We used standardised patients (SPs) to measure technical and patient experience a sample facilities Mumbai. Results SPs presented ‘classic, suspected TB’ scenario ‘recurrence or drug-resistance’ scenario. In the sector, completed 643 interactions. 164 Outcomes included indicators correct management, medication use client experience. Public providers microbiological...
Background Childhood and adolescent drug-resistant TB (DR-TB) is one of the neglected infectious diseases. Limited evidence exists around programmatic outcomes children adolescents receiving DR-TB treatment. The study aimed to determine final treatment outcomes, culture conversion rates factors associated with unsuccessful outcome in DR-TB. Methods This a descriptive including (0–9 years) (10–19 were who initiated on ambulatory based between January 2017-June 2018 Shatabdi hospital, Mumbai,...
The WHO endorsed Xpert Mycobacterium tuberculosis/rifampicin (MTB/RIF) assay, has been evaluated for pulmonary TB in a number of studies but very few have investigated it extrapulmonary specimens. present study evaluates the performance MTB/RIF assay diagnosis (EPTB).The aim is to determine sensitivity and specificity EPTB RIF resistance comparison culture on Lowenstein-Jensen (LJ) medium proportion method (PM), respectively.A total 738 specimens from clinically suspected cases were...
Private providers dominate health care in India and provide most tuberculosis (TB) care. Yet efforts to engage private were viewed as unsustainably expensive. Three provider engagement pilots implemented Patna, Mumbai Mehsana 2014 based on the recommendations National Strategic Plan for TB Control, 2012-17. These sought improve diagnosis treatment of increase case notifications by offering free drugs diagnostics patients who among providers, monetary incentives one pilots. As these...
Abstract The present study was initiated to understand the proportion of predominant variants severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in postvaccination infections during Delta dominated second wave disease 2019 (COVID‐19) Mumbai Metropolitan Region (MMR) India and any mutations selected or showing association with patient demographics. Samples were collected ( n = 166) from severe/moderate/mild COVID‐19 patients who either vaccinated (COVISHIELD/COVAXIN—partial/fully...
Tuberculosis (TB) remains a significant cause of mortality globally, with India accounting for 27% the estimated number people TB. Multidrug-resistant TB (MDR-TB) and isoniazid (INH) resistance pose additional challenges to effective treatment. We aimed describe treatment outcomes INH mono-resistant patients under programmatic conditions in Mumbai, India.
To determine the bacteriological conversion rate after 6 months of Delamanid (DLM) based treatment in children with drug-resistant tuberculosis (DR-TB) and factors associated conversion.
This study aimed to compare the vitamin D levels between chronic obstructive pulmonary disease (COPD) patients and healthy controls describe correlation lung functions.Fifty COPD (cases) 30 volunteers (controls) were recruited their serum level was measured together with function (forced vital capacity forced expiratory volume in 1 s [FEV1]) by spirometry. categorized as ≤20 nmol/l: deficient, 21-50 inadequate, ≥51 nmol/l sufficient.In this case-control cross-sectional study, lower...
Introduction Vitamin D status may be an important determinant of multidrug-resistant tuberculosis (MDR-TB) infection, progression to disease and treatment outcomes. Novel potentially cost-effective therapies such as vitamin supplementation are needed stem the tide TB MDR-TB globally, particularly in India, a country that accounts for largest fraction world’s incidence incidence, where deficiency is endemic. While has shown some promise MDR-TB, its role context infection largely unknown....
BACKGROUND: Half of India´s three million TB patients are treated in the largely unregulated private sector, where quality care is often poor. Private provider interface agencies (PPIAs) seek to improve sector care, which can be measured terms case fatality and recurrence rates. METHODS: We conducted a retrospective cohort survey 4,000 managed by PATH PPIA between 2014 2017. estimated treatment post-treatment case-fatality ratios (CFRs) used Cox proportional hazards models identify...
Abstract With the continuous emergence of SARS-CoV-2 variants concern and implementation mass-scale interventions like vaccination, understanding factors affecting disease transmission has critical implications for control efforts. Here we used a simple adapted N95 mask sampling method to demonstrate impact circulating vaccination on 92 COVID-19 patients expel virus into air translating risk. Between July September 2021, when Delta was dominant strain in Mumbai, noted two-fold increase...
This study used an adapted N95 mask sampling to understand the effect of COVID-19 vaccination in context circulating variants on infected individuals emit virus into air, a key risk factor transmission. Mask, swab, and blood samples were collected from 92 patients vaccinated (Covishield/COVAXIN-partial/fully) or unvaccinated between July September 2021 during Delta-dominated period Mumbai. Mask/swab analyzed by reverse transcription polymerase chain reaction for viral RNA. Blood was...
Recent breakthroughs in large language models (LLMs) have generated both interest and concern about their potential adoption as accessible information sources or communication tools across different domains. In public health -- where stakes are high impacts extend populations adopting LLMs poses unique challenges that require thorough evaluation. However, structured approaches for assessing risks remain under-explored. To address this gap, we conducted focus groups with professionals issue...