A5031856393- Alzheimer's disease research and treatments
- Supramolecular Self-Assembly in Materials
- Parkinson's Disease Mechanisms and Treatments
- HIV Research and Treatment
- Protein Structure and Dynamics
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Computational Drug Discovery Methods
- Advanced Glycation End Products research
- Monoclonal and Polyclonal Antibodies Research
- Nuclear Receptors and Signaling
- Proteins in Food Systems
- Biotin and Related Studies
- Immune Cell Function and Interaction
- 3D Printing in Biomedical Research
Lund University
2021-2025
University of the Basque Country
2018
Instituto Biofisika
2018
Shear forces affect self-assembly processes ranging from crystallization to fiber formation. Here, the effect of mild agitation on amyloid fibril formation was explored for four peptides and investigated in detail A <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" overflow="scroll"> <mml:mrow> <mml:mi mathvariant="bold">β</mml:mi> </mml:mrow> </mml:math> 42, which is associated with Alzheimer’s disease. To gain mechanistic insights into agitation, nonseeded seeded...
Oligomeric assemblies consisting of only a few protein subunits are key species in the cytotoxicity neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. Their lifetime solution abundance, governed by balance their sources sinks, thus important determinants disease. While significant advances have been made elucidating processes that govern oligomer production, mechanisms behind dissociation still poorly understood. Here, we use chemical kinetic modeling to determine...
0. Abstract α-Synuclein (αSyn) is a neuronal protein predominantly found in the brain, whose native function seems to be associated with vesicle trafficking. While intrinsically disordered solution, first ca. 100 residues adopt an amphipathic α-helical structure when adsorbs onto membranes. Additionally, aggregation of αSyn into highly ordered β-sheet rich amyloid fibrils Parkinsońs disease. The different regions and interactions between them have been reported play key role behaviour its...
The 10E8 antibody targets a helical epitope in the membrane-proximal external region (MPER) and transmembrane domain (TMD) of envelope glycoprotein (Env) subunit gp41 is among broadest known neutralizing antibodies against HIV-1. Accordingly, this its mechanism action valuably inform design effective vaccines immunotherapies. exhibits unusual adaptations to attain specific, high-affinity binding MPER at viral membrane interface. Reversing charge basic paratope surface (from net positive...
Aggregated α-synuclein (α-syn) is the main constituent of Lewy bodies, which are a pathological hallmark Parkinson’s disease (PD). Environmental factors thought to be potential triggers capable initiating aggregation otherwise monomeric α-syn. Braak’s seminal work redirected attention intestine and recent reports dysbiosis have highlighted causative role microbiome in initiation pathology PD. Staphylococcus aureus bacterium carried by 30–70% general population. It has been shown produce...
Photo-induced cross-linking of unmodified proteins (PICUP) has been used in the past to study size distributions protein assemblies. PICUP may, for example, overcome significant experimental challenges related transient nature, heterogeneity, and low concentration amyloid oligomers relative monomeric fibrillar species. In current study, a reaction chamber was designed, produced, optimization terms conditions lighting time from ms s. These efforts make method more reproducible accessible...