A5061592143- Adenosine and Purinergic Signaling
- Salivary Gland Disorders and Functions
- Fibroblast Growth Factor Research
- Neuropeptides and Animal Physiology
- Cancer Immunotherapy and Biomarkers
- Vagus Nerve Stimulation Research
- Viral Infections and Outbreaks Research
- Pharmacological Receptor Mechanisms and Effects
- Neonatal Respiratory Health Research
- Tryptophan and brain disorders
- SARS-CoV-2 and COVID-19 Research
- Diabetes Treatment and Management
- Pediatric health and respiratory diseases
- Neuroendocrine Tumor Research Advances
- COVID-19 Impact on Reproduction
- Bacteriophages and microbial interactions
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Genetics and Neurodevelopmental Disorders
- Urticaria and Related Conditions
- Cancer, Hypoxia, and Metabolism
- Microbial metabolism and enzyme function
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes and associated disorders
- Inflammasome and immune disorders
University of Missouri
2013-2024
Center for Life Sciences
2017
Inflammation of the salivary gland is a well-documented aspect dysfunction that occurs in Sjogren's syndrome (SS), an autoimmune disease, and γ-radiation-induced injury during treatment head neck cancers. Extracellular nucleotides have gained recognition as key modulators inflammation through activation cell surface ionotropic metabotropic receptors, although contribution extracellular to not well understood. In vitro studies using submandibular (SMG) aggregates isolated from wild-type...
Transforming growth factor-β (TGF-β) is a multi-functional cytokine with well-described role in the regulation of tissue fibrosis and regeneration liver, kidney lung. Submandibular gland (SMG) duct ligation subsequent deligation rodents classical model for studying salivary damage regeneration. While previous studies suggest that TGF-β may contribute to fibrosis, expression signaling components has not been investigated relation mouse SMG ligation-induced following ductal deligation....
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections remain unmanageable in some parts of the world. As with other RNA viruses, mutations SARS-CoV-2 gene have been continuously evolving. Recently, four variants identified, B.1.1.7, B.1.351, P.1 and CAL.20C. These appear to be more infectious transmissible than original Wuhan-Hu-1 virus. Using a combination bioinformatics structural analyses, we show that new emerged background an already known Spike protein mutation D614G...
The pro-inflammatory cytokine interleukin-1β (IL-1β), whose levels are elevated in the brain Alzheimer's and other neurodegenerative diseases, has been shown to have both detrimental beneficial effects on disease progression. In this article, we demonstrate that incubation of mouse primary cortical neurons (mPCNs) with IL-1β increases expression P2Y2 nucleotide receptor (P2Y2R) activation up-regulated UTP, a relatively selective agonist P2Y2R, neurite outgrowth. Consistent accepted role...
Annually, >600,000 new cases of head and neck cancer (HNC) are diagnosed worldwide with primary treatment being surgery radiotherapy. During ionizing radiation (IR) HNC, healthy salivary glands collaterally damaged, leading to loss function that severely diminishes the quality life for patients due increased health complications, including oral infections sores, cavities, malnutrition, among others. Therapies hypofunction ineffective largely palliative, indicating a need further research...
Abstract CD40/CD40L interactions play a critical role in immunity and autoimmunity. In this study, we sought to understand the requirement for CD40 signaling programmed cell death-1 (PD-1) checkpoint CD28 costimulatory pathways important maintenance of peripheral tolerance. Blocking either pathway can result loss self-tolerance development We found that primary Sjögren’s syndrome (pSS) autoimmune thyroid diseases (ATDs) develop spontaneously CD28-deficient IFN-γ−/− NOD.H-2h4 (CD28−/−) mice...
Hyposalivation resulting from salivary gland dysfunction leads to poor oral health and greatly reduces the quality of life patients. Current treatments for hyposalivation are limited. However, regenerative medicine replace dysfunctional glands represents a revolutionary approach. The ability dispersed epithelial cells or gland-derived progenitor self-organize into acinar-like spheres branching structures that mimic native tissue holds promise cell-based reconstitution functional gland....
Abstract Sixty to seventy percent of IFN-γ−/− NOD.H-2h4 mice given sodium iodide (NaI)–supplemented water develop a slow onset autoimmune thyroid disease, characterized by thyrocyte epithelial cell (TEC) hyperplasia and proliferation (H/P). TEC H/P develops much earlier in CD28−/− nearly 100% (both sexes) have severe at 4 mo age. Without NaI supplementation, 50% 5- 6-mo-old CD28−/−IFN-γ−/− H/P, 2–3 wk is sufficient for optimal development H/P. Mice with are hypothyroid, normalization serum...
Abstract Global spread of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has triggered unprecedented scientific efforts, as well containment and treatment measures. Despite these SARS-CoV-2 infections remain unmanageable in some parts the world. Due to inherent mutability RNA viruses, it is not surprising that genome been continuously evolving since its emergence. Recently, four functionally distinct variants, B.1.1.7, B.1.351, P.1 CAL.20C, have identified, they appear more...
To develop a mouse model of human dry eye disease (DED) for investigation sex differences in autoimmune-associated pathology.Ocular surface was assessed by quantifying corneal epithelial damage with lissamine green stain the NOD.H-2h4,IFNγ-/-,CD28-/- (NOD.H-2h4 DKO) Sjögren's syndrome (SS). Lacrimal gland function tear volume quantification phenol red thread and lacrimal inflammation (i.e., dacryoadenitis) immune cell foci, flow cytometric analysis composition, expression proinflammatory...