A5080716656- Reconstructive Surgery and Microvascular Techniques
- Cancer Immunotherapy and Biomarkers
- Breast Implant and Reconstruction
- Cutaneous Melanoma Detection and Management
- Immune cells in cancer
- Melanoma and MAPK Pathways
- Occupational exposure and asthma
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Lung Cancer Treatments and Mutations
- Acute Myocardial Infarction Research
- Surgical site infection prevention
- Pancreatic and Hepatic Oncology Research
- Occupational and environmental lung diseases
- Reconstructive Facial Surgery Techniques
- Nausea and vomiting management
- Pleural and Pulmonary Diseases
- Cardiac electrophysiology and arrhythmias
- Neuroendocrine Tumor Research Advances
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Atrial Fibrillation Management and Outcomes
- Peptidase Inhibition and Analysis
Ospedale Policlinico San Martino
2012-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2012
National Cancer Research Institute
2010-2012
Open colorectal cancer (CRC) surgery induces severe and prolonged postoperative pain. The optimal method of analgesia in CRC has not been established. We evaluated the efficacy preperitoneal continuous wound infusion (CWI) ropivacaine for after open a multicenter randomized controlled trial.Candidates randomly received CWI or epidural (CEI) with 0.2% 10 mL/h 48 hours surgery. Fifty-three patients were allocated to each group. All patient-controlled IV morphine analgesia.Over 72-hour period...
Summary A multicenter study of a recently developed ELISA for the determination prothrombin fragment Fl+2 was performed in order to evaluate analytical and clinical aspects. Mean intra-assay inter-assay reproducibility were found be 11.0 12.6%, respectively. The measuring range covered by calibration curve reaches from 0.04 10.0 nM/1 Fl+2. Testing 133 healthy subjects reference 0.37 1.11 (2.5–97.5 percentile) with median 0.66 F1+2 calculated. Minor difficulties blood sampling (venous...
Background: Infection is a severe potential complication of breast implant positioning in women with cancer. There still some degree uncertainty regarding optimal antibiotic prophylaxis regimens, infecting pathogens, and risk factors associated infection during long-term followup these patients. Methods: We performed systematic clinical review to assess microorganisms among patients undergoing reconstructive procedures for cancer between January 2005 February 2007. A randomly selected group...
A soluble mesothelin-related peptide (SMRP) is the only FDA-approved biomarker for diagnosis of pleural mesothelioma (PM) and most used monitoring treatment. Radiological assessment PM, based on modified RECIST (mRECIST) criteria, challenging. This pilot study was designed to evaluate whether SMRP levels correlated over time with mRECIST score. Serial serum samples from PM patients were collected measured compared score obtained through centralized CT scans by blinded review. The...
e21157 Background: CTLA-4, a close homologue to CD28, is vital negative regulator of T-cell activation and proliferation. We previously reported that CTLA-4 expressed by NSCLC cell lines providing evidence its involvement in apoptosis induction upon engagement with soluble ligands (Contardi E, Int J Cancer 2005). The present study examined the expression on tumor tissues patients (pts) radically resected stage I-IIIA NSCLC. Methods: Tumor tissue samples from 82 pts who underwent surgery...
Objectives: Rare tumors (RT) collectively account for one quarter of all malignancies in Italy. The low frequency and the large heterogeneity natural history outcome individual diseases, together with a scarcity epidemiological information make them challenge clinical practice, as well public healthcare organizations. We conducted retrospective study to quantify burden hospitalization real-word setting patients diagnosed these diseases an Italian region. Methods: RT were tracked along...
Background: Survival rates for metastatic melanoma (MM) patients have improved in recent years, leading to major expenses and health resource use. We conducted a non-concurrent prospective study describe the burden of hospitalization real-world setting with MM. Methods: Patients were tracked throughout all hospital stays 2004–2019 by means discharges. The number hospitalizations, rehospitalization rate, average time spent span between consecutive admissions evaluated. Relative survival was...