A5053546014- Fluorine in Organic Chemistry
- Sulfur-Based Synthesis Techniques
- Particle physics theoretical and experimental studies
- Cyclopropane Reaction Mechanisms
- Quantum Chromodynamics and Particle Interactions
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- High-Energy Particle Collisions Research
- Advanced Drug Delivery Systems
- Asymmetric Synthesis and Catalysis
- Synthesis and Reactions of Organic Compounds
- Medical Imaging Techniques and Applications
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Inorganic Fluorides and Related Compounds
- Synthesis of Indole Derivatives
- Automotive and Human Injury Biomechanics
- Organoboron and organosilicon chemistry
- Chemical Synthesis and Reactions
- Boron Compounds in Chemistry
- Membrane Separation and Gas Transport
- Vacuum and Plasma Arcs
- Anesthesia and Neurotoxicity Research
- Vehicle Noise and Vibration Control
- Catalytic Alkyne Reactions
Fuzhou University
2025
Nanjing Institute of Technology
2023-2024
Huaqiao University
2020-2024
Nanjing University of Aeronautics and Astronautics
2024
Shandong First Medical University
2024
Fudan University
2024
Shenyang Pharmaceutical University
2021-2024
Energy Research Institute
2024
Northwestern Polytechnical University
2024
Beijing Normal University
2022
Interfacing aptamers with carbon fiber microelectrodes (CFEs) provides a versatile platform to probe the chemical activity in living brain at molecular level. However, new approaches are needed for efficient and stable modification of electrode surfaces aptamers. Here, we present an electrochemical conjugation strategy covalently couple onto CFEs high chemoselectivity, efficiency, stability sensing brain. The employs initial coupling catechol on CFE, thereby generating thin layer quinone...
A convenient method for the synthesis of fluorine-containing heterocyclic compounds was developed by a copper-catalyzed free radical addition reaction alkynol and ethyl bromodifluoroacetate. This strategy involves molecular lactone exchange ethynyl alcohol The is characterized easy availability raw materials, good stereochemical selectivity, simple operation. More importantly, valuable tetrasubstituted E-configurated alkenes various vinyl C-Br bonds difluoromethylene-containing...
We report herein an efficient strategy to construct 3-(2,2-difluoroethyl)-2-fluoroindoles from activated o-aminostyrenes with ethyl bromodi-fluoroacetate as a difluorocarbene source. Through double capture of difluorocarbene, two different types fluorine motifs are incorporated into the products simultaneous construction one C–N and C–C bonds, without need for transition metals. This reaction features high efficiency excellent functional group compatibility has great potential in late-stage...
Chiral sp 3 -geminated bimetallic reagents based on B, Si, and Sn have drawn much attention due to their unique structure reaction mode. This review summarizes the synthesis of nonracemic gem -borylstannyl, -borylsilyl, -diboryl compounds.
Herein, we report a transition-metal-free [4 + 1] cyclization pathway from difluorocarbene and ortho-amino aryl alkynone, rendering an effective universal strategy for the construction of 3-alkenyl-2-oxindoles. Our starts cheap accessible alkynone instead direct indole skeleton; moreover, in situ generated commercially available halogenated difluoroalkylative reagents enables cleavage C–N bond formation new bonds C–C bonds.
As an important part of head protection equipment, research on the material and structural application helmet liners has always been one hotspots in field helmets. This paper first discusses common liner materials, including traditional polystyrene, polyethylene, polypropylene, etc., as well newly emerging anisotropic polymer nanocomposites, etc. Secondly, design concept structure is discussed, use a multi-layer structure, addition geometric irregular bubbles to enhance energy absorption...
Abstract During the past decade, radical difluoromethylation has emerged as a powerful and versatile tool for incorporation of difluoromethyl into various organic compounds. These reactions feature mild reaction conditions, very good functional group compatibilities, quite broad substrate scopes, thus having drawn much attention got rapid developments. A diverse range precursors have been developed series reactions. This review summarizes discusses advance in reactions, which are organized...
Abstract A thorough understanding of the internal conversion process between excited states is important for designing ideal multiple‐emissive materials. However, it hard to experimentally measure both energy barriers and gaps a compound. For long time, dubious if what was measured gap or barrier two states. In this paper, we designed 1‐(pyren‐2’‐yl)‐9,12‐ di ( p ‐tolyl)‐ o ‐carborane 2 ), which shows dual‐emission in solution. Temperature‐dependent fluorescence measurements show that...
As a crucial part of head protection equipment, research on the material and structural application helmet liners has always been hot topic in field manufacturing. This paper aims to introduce most common liner materials, including traditional polystyrene, polyethylene, polypropylene, others, as well emerging materials such anisotropic polymer nanocomposites. In addition, design principles structure are discussed, evolution multi-layer structure, integration geometric irregular bubbles,...
The air conditioning compressor is a critical component in automobile heating, ventilation and systems. However, noise has long been problem for manufacturers. In recent years, the development application of scroll compressors increased significantly due to their low mechanical vibration noise. limitations terms airflow pulse cannot be ignored, especially speed high load conditions where generated negative impact on driving passenger experience. Noise pulses are important considerations that...
Abstract The enantioselective introduction of gem ‐difluorinated carbonyl (i. e. α , ‐difluoro carbonyl) moieties into organic structures is a synthetically valuable but highly challenging approach. During the past decades, continuous efforts have been made for developments synthetic strategies constructing C( sp 3 )−CF 2 COR chiral centers with high levels enantioselectivities. This review summarizes and discusses recent advance in construction moieties, which are organized according to...
Nanosuspensions (NS) can enhance the saturation solubility and dissolution velocity of poorly soluble drugs. PEG as a non-ionic surfactant plays an important role in surface modification nanoparticles for prolonging vivo circulation. In this study, anti-solvent precipitation method was introduced to prepare gambogenic acid nanosuspensions (GNA-NS) with PVPK30 PEG2000 stabilizers settle disadvantages GNA. The obtained were spherical mean particle size 183.7 nm zeta potential -22.8 mV....
1,3-Oxazin-6-ones as important structural scaffolds widely exist in many bioactive or therapeutic agents.
Abstract Spontaneous condensation occurs due to high steam speeds, leading droplets in the stream that not only decrease performance but also hazard security of nozzle. This study aims predict position and size suitable injected water reduced losses liquid mass fraction. Firstly, model flow has been confirmed by experimental data using Eulerian–Eulerian approach Moore’s nozzle B. Then, turbulence caused phase change is modelled k – w sst model. injection applied three sizes (coarse, medium,...
Presented herein is a newly designed strategy that rapidly introduces ethyl difluoroacetate radicals through dialkylzincs induced radical 1,6-conjugate addition pathway.
An efficient and convenient synthesis of benzo[d][1,3]thiazine has been developed by employing a copper-catalyzed transformation readily available ketone-derived hydrazones with elemental sulfur bromodifluoroalkylative reagents. The strategy involves an S8-catalyzed selective triple-cleavage bromodifluoroacetamides, which acts as C1 synthon at the 2-position benzo[d][1,3]thiazine. A mechanism proceeding through Cu–carbene intermediate is proposed for C–S bond formation.
A Cu-catalyzed enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds is described. Two contiguous stereocenters including one all-carbon quaternary stereocenter are constructed with good stereoselectivity atom economy.
An important framework of o-amino benzofuranthioethers was constructed by Cu-catalyzed arylative cyclization N-tosylhydrazone-bearing thiocarbamates with silylaryl triflates or ArI. This transformation provides a novel strategy for the synthesis valuable in moderate yields which could not be obtained from known methods. The reaction features smart design, efficient construction, and mild conditions.
In order to solve the problem of imbalance internal forces in system caused by gravity force eccentric wheel and orbiting scroll close drive bearing rotational inertia during operation electric compressor, a dynamic model rotor compressor that takes into account effect gas was established using multibody dynamics software ADAMS/View 2020. Dynamic simulation analysis is carried out, focusing on bearing; parametric optimization method adopted optimize position center-of-mass coordinates...
Platensilin, platensimycin, and platencin are potent inhibitors of β-ketoacyl-acyl carrier protein synthase (FabF) in the bacterial mammalian fatty acid synthesis system, presenting promising drug leads for both antibacterial antidiabetic therapies. Herein, a bioinspired skeleton reconstruction approach is reported, which enables unified these three natural FabF their skeletally diverse analogs, all stemming from common