A5020210993- Photodynamic Therapy Research Studies
- Laser Applications in Dentistry and Medicine
- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Oral Health Pathology and Treatment
- Ocular Infections and Treatments
- Nanoplatforms for cancer theranostics
- NF-κB Signaling Pathways
- 3D Printing in Biomedical Research
- Bone health and osteoporosis research
- Psoriasis: Treatment and Pathogenesis
- Bone and Joint Diseases
- Immune Response and Inflammation
- Antifungal resistance and susceptibility
- T-cell and B-cell Immunology
- Bone Tissue Engineering Materials
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Dental Erosion and Treatment
- Bone health and treatments
- Osteomyelitis and Bone Disorders Research
Aichi Gakuin University
2013-2023
Antimicrobial photodynamic therapy (aPDT) is a new treatment method for the removal of infectious pathogens using photosensitizer and light specific wavelength, e.g., toluidine blue with wavelength about 600 nm. We explored focused on indocyanine green (ICG), which has high absorption at 800-805 investigated bactericidal effect PDT Porphyromonas gingivalis photosensitizer, ICG-loaded nanospheres an 805 nm low-level diode laser irradiation.We designed coated chitosan (ICG-Nano/c) as...
Gelatin methacryloyl (GelMA) is a versatile biomaterial that has been used in various biomedical fields. UV light commonly to photocrosslink such materials; however, its use raised several biosafety concerns. We investigated the mechanical and biological properties of visible-wavelength (VW)-light-crosslinked gelatin-based hydrogel evaluate viability as scaffold for bone regeneration bone-destructive disease treatment. Irgacure2959 or riboflavin was added photoinitiator create GelMA...
Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjunctive strategy for periodontitis treatments. However, use of aPDT periodontal treatment is complicated by the difficulty in accessing morphologically complex lesions such furcation involvement, which irradiation beam (which targeted parallel to tooth axis into pocket) cannot access directly. The aim this study was validate a modified method that photosensitizes indocyanine green-loaded nanospheres through gingivae from...
Background and Objective T‐helper type 17 ( T h17) cells produce interleukin‐17 IL ‐17) help to protect against inflammation infection in periodontal disease. Furthermore, while follicular dendritic cell‐secreted protein FDC ‐ SP ) may be involved the of tissue, biological role FDP disease is still unknown. The purpose present study was clarify expression ‐17 experimental periodontitis rats. Material Methods Seven‐week‐old male Wistar rats were divided into baseline control, sham test...
Background Interleukin (IL)-17 produced by mainly T helper 17 (Th17) cells may play an important destructive role in chronic periodontitis (CP). Thus, anti-inflammatory cytokines, such as IL-35, might have a beneficial effect inhibiting differentiation of Th17 cells. is regulated the retinoic acid receptor-related orphan receptor (ROR) α (encoded RORA ) and ROR γ t RORC ). However, IL-35 not clear on function still incompletely understood. Therefore, we investigated effects Methods...
Apical periodontitis, an inflammatory lesion causing bone resorption around the apex of teeth, is treated by eradicating infectious bacteria from root canal. However, it has a high recurrence rate and often requires retreatment. We investigated bactericidal effect antimicrobial photodynamic therapy (aPDT)/photodynamic chemotherapy (PACT) using indocyanine green (ICG)-loaded nanospheres coated with chitosan diode laser on biofilm Enterococcus faecalis, pathogen refractory apical...
Antimicrobial photodynamic therapy (aPDT) is an effective method for eradicating bacteria in periodontal therapy. Standard aPDT requires the insertion of a laser tip into pocket, which direction irradiation limited. Therefore, we devised that uses transgingival near-infrared wavelength and indocyanine green-encapsulated chitosan-coated nanoparticles as photosensitizer.
The oropharyngeal area can be a source of halitosis.However, the relationship between healthy tonsillar microbiota and halitosis is poorly understood.We conducted pilot clinical study to clarify effect gargling with an antiseptic agent on in patients halitosis.Twenty-nine who did not have otolaryngologic disease or periodontitis were assigned randomly one three groups: benzethonium chloride (BZC) gargle; placebo no gargle.Concentrations volatile sulfur compounds (VSCs) mouth air,...
The aim of this study was to investigate the effect laser irradiation on root surface demineralization caused by local drug delivery systems (DDS), and evaluate sealing retention.The duration supportive periodontal treatment (SPT) has increased with increasing life expectancy. Repeated planing DDS application during SPT should be reconsidered regard their effects surface.Extracted human teeth were collected, cut into 3 × 2 mm dentin specimens, divided randomly eight groups various...
レーザーとインドシアニングリーンナノ粒子を使ったポケット外からのレーザー照射による抗菌光線力学療法(a-PDT)を開発し,認定臨床研究審査会の審査を経て,試験研究を行った。a-PDTは,レーザーを光感受性物質に照射し,一重項酸素を発生させて殺菌する方法である。810 nmの波長のレーザー光は,その吸光スペクトルの特徴から生体透過性があることが知られており,この性質を利用し,ポケット外からのレーザー照射でポケット内細菌を除去する新たな方法を試みた。SPT期の歯周病患者40名を実験群とコントロール群に無作為にわけ,ポケット内細菌のコントロールが基礎研究で得られた条件で可能かを検討した。結果歯周ポケット外からのレーザー照射で,ポケット内細菌の除去は可能であった。このa-PDTの原理を紹介するとともに,平成30年から施行された臨床研究法に則った認定臨床研究審査委員会の審査を受けた諸手続きについて紹介する。