A. M. Burger
A5031425253- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Dark Matter and Cosmic Phenomena
- Computational Physics and Python Applications
- Neutrino Physics Research
- Cosmology and Gravitation Theories
- Distributed and Parallel Computing Systems
- Telomeres, Telomerase, and Senescence
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Astrophysics and Cosmic Phenomena
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Atomic and Subatomic Physics Research
- Multiple Myeloma Research and Treatments
- Toxin Mechanisms and Immunotoxins
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Superconducting Materials and Applications
- Advanced Data Storage Technologies
- Transgenic Plants and Applications
- Structural Analysis of Composite Materials
- Protein Degradation and Inhibitors
European Organization for Nuclear Research
2024-2025
Oklahoma State University
2019-2024
Université Clermont Auvergne
2022-2024
Institut National de Physique Nucléaire et de Physique des Particules
2017-2024
Centre National de la Recherche Scientifique
2017-2024
AGH University of Krakow
2024
Jagiellonian University
2024
Oklahoma State University Oklahoma City
2024
University of Toronto
1996-2024
A. Alikhanyan National Laboratory
2024
The pentacyclic acridinium methosulfate salt RHPS4 induces the 3′single-stranded guanine-rich telomeric overhang to fold into a G-quadruplex structure. Stabilisation of latter is incompatible with an attachment telomerase telomere and thus ligands can effectively inhibit both catalytic capping functions telomerase. In this study, we examined mechanisms underlying uncapping by in uterus carcinoma cells (UXF1138L) short telomeres compared susceptibility bulk clonogenic cancer ligand. We show...
A bstract The first FASER search for a light, long-lived particle decaying into pair of photons is reported. uses LHC proton-proton collision data at $$ \sqrt{s} <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 . 6 TeV collected in 2022 and 2023, corresponding to an integrated luminosity 57 7 fb − 1 model with axion-like particles (ALPs) dominantly coupled weak gauge bosons the primary target. Signal events are...
The expression of side-population (SP) cells and their relation to tumour-initiating (T-ICs) have been insufficiently studied in breast cancer (BC). We therefore evaluated primary cell cultures derived from patients a panel human BC lines with luminal- or basal-molecular signatures for the presence SP stem markers. SPs luminal-type were analysed T-IC characteristics, including epidermal growth factor receptor 2 (HER2), ERα, IGFBP7 ability initiate tumours non-obese diabetic severe combined...
Drug resistance remains a clinical challenge in cancer treatment due to poor understanding of underlying mechanisms. We have established several drug-resistant prostate cell lines by long-term culture medium containing chemotherapeutic drugs. These resistant displayed significant increase side population cells overexpression drug efflux pumps including ABCG2/BCRP and MDR1/Pgp. To uncover potential mechanisms resistance, we performed microarray analysis identify differentially expressed genes...
The first results of the study high-energy electron neutrino (ν_{e}) and muon (ν_{μ}) charged-current interactions in FASERν emulsion-tungsten detector FASER experiment at LHC are presented. A 128.8 kg subset volume was analyzed after exposure to 9.5 fb^{-1} sqrt[s]=13.6 TeV pp data. Four (eight) ν_{e} interaction candidate events observed with a statistical significance 5.2σ (5.7σ). This is direct observation particle collider includes highest-energy ν_{μ} ever detected from an artificial...
The breast cancer-associated T2A10 clone was originally isolated from a cDNA library enriched for tumour messenger ribonucleic acids. Our survey of 125 microarrayed primary tissues using affinity purified polyclonal antibodies has revealed that corresponding protein is overexpressed in invasive cancer and weakly expressed kidney prostate tumours. Now known as RNF11, the gene encodes RING-H2 domain PY motif, both which mediate protein–protein interactions. In particular, PPPPY sequence RNF11...
This paper presents the first results of study high-energy electron and muon neutrino charged-current interactions in FASER$\nu$ emulsion/tungsten detector FASER experiment at LHC. A subset volume, which corresponds to a target mass 128.6~kg, was exposed neutrinos from LHC $pp$ collisions with centre-of-mass energy 13.6~TeV an integrated luminosity 9.5 fb$^{-1}$. Applying stringent selections requiring electrons reconstructed above 200~GeV, four interaction candidate events are observed...
The Forward Search Experiment (FASER) at CERN’s Large Hadron Collider (LHC) has recently directly detected the first collider neutrinos. Neutrinos play an important role in all FASER analyses, either as signal or background, and it is therefore essential to understand neutrino event rates. In this study, we update previous simulations present prescriptions for theoretical predictions of fluxes cross sections, together with their associated uncertainties. With these results, discuss potential...
The High Granularity Timing Detector (HGTD) will be installed in the ATLAS experiment to mitigate pile-up effects during Luminosity (HL) phase of Large Hadron Collider (LHC) at CERN. Low Gain Avalanche Detectors (LGADs) provide high-precision measurements time arrival particles HGTD, improving particle-vertex assignment. To cope with high-radiation environment, LGADs have been optimized by adding carbon gain layer, thus reducing acceptor removal rate after irradiation. Performances several...
Tumour hypoxia confers poor prognosis in a wide range of solid tumours, due to an increased malignancy, likelihood metastasis and treatment resistance. Poorly oxygenated tumours are resistant both radiation therapy chemotherapy. However, although the link between is well established clinical studies, evidence its influence on chemotherapy response lacking. In this study, panel human tumour-derived xenografts that have been characterised previously for vivo large series anti-cancer agents,...
8548 Vorinostat, a histone deacetylase inhibitor, affects cell growth by modifying the transcription of cellular proteins (histones, factors, ubiqutin E3 ligases and stress response proteins). In vitro, vorinostat showed synergistic cytotoxicity with proteasome inhibitors in MM cells disruption aggresome function induction ER (Pei, 2004). The study aims were to determine MTD, pharmacokinetics (PK) pharmacodynamics (PD) plus Bort pts. Twenty-three pts treated. Median age was 54 yrs (range...
Although strong evidence is mounting that telomerase reactivation and the thereof resulting stabilization of telomeres a major mechanism for human cells to overcome replicative senescence, causal relationship linking activation conclusively tumorigenesis remains be established. Thus, possibility exists passively co-selected as tumors develop. To elucidate function during tumorigenesis, we followed immortalization primary cell types with in vitro transforming agents determined tumorigenic...
X-linked immune deficient (Xid) mice fail to produce anti-phosphocholine (PC) antibodies even after immunization with Streptococcus pneumoniae. Consequently, Xid are extremely susceptible infection S. pneumoniae, PC-specific B cells appear undergo clonal deletion in mice; however, a new thymus-dependent form of PC, 6-(O-phosphocholine)hydroxyhexanoate (EPC), can rescue from the bone marrow presumably by providing T cell help before deletion. Analysis IgG hybridomas revealed utilization...
The pyrrolobenzodiazepine monomer DRH-417 is a member of the anthramycin group anti-tumor antibiotics that bind covalently to N2 guanine within minor groove DNA. emerged from EORTC-Drug Discovery Committee and NCI 60 cell line in vitro screening programs as potent antiproliferative agent with differential sensitivity towards certain cancer types such melanoma, breast renal carcinoma (mean IC(50) = 3 nM). was therefore tested for vivo activity. maximum tolerated dose (MTD) established 0.5...