A5026384256- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Wastewater Treatment and Nitrogen Removal
- Salmonella and Campylobacter epidemiology
- Hydrocarbon exploration and reservoir analysis
- Genomic variations and chromosomal abnormalities
- Environmental DNA in Biodiversity Studies
- Microbial bioremediation and biosurfactants
- Genomics and Rare Diseases
- Prenatal Screening and Diagnostics
- Methane Hydrates and Related Phenomena
- Molecular Biology Techniques and Applications
- Algal biology and biofuel production
- Microplastics and Plastic Pollution
- Zebrafish Biomedical Research Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Homelessness and Social Issues
- Enhanced Oil Recovery Techniques
- Microbial infections and disease research
- Protist diversity and phylogeny
- Petroleum Processing and Analysis
- Water Treatment and Disinfection
- Neuroinflammation and Neurodegeneration Mechanisms
- Reservoir Engineering and Simulation Methods
- Concrete and Cement Materials Research
Manchester University NHS Foundation Trust
2024
Carleton University
2023-2024
Health Canada
2024
University of Manchester
2021-2023
St Mary's Hospital
2023
Manchester Academic Health Science Centre
2021
Institute of Groundwater Ecology
2016-2019
Helmholtz Zentrum München
2016-2019
McMaster University
2016
Stevens Institute of Technology
1992
It has recently been suggested that oxygenic dismutation of NO into N
Bisphenol A (BPA), a widely used chemical in the production of plastics and epoxy resins, has garnered significant attention due to its association with adverse health effects, particularly endocrine-disrupting properties. Regulatory measures aimed at reducing human exposure BPA have led proliferation alternative chemicals various consumer industrial products. While these alternatives serve reduce exposure, concerns arisen regarding their safety potential toxicity as regrettable substitutes....
Oxygenic denitrification represents a new route in reductive nitrogen turnover which differs from canonical how nitric oxide (NO) is transformed into dinitrogen gas. Instead of NO reduction via N2O to N2, proposed be directly disproportionated N2 and O2 oxygenic denitrification, catalyzed by the putative dismutase (Nod). Although high diversity nod genes has been recovered various environments, still little known about niche partitioning ecophysiology denitrifiers. One constraint that as...
While most studies using RNA-stable isotope probing (SIP) to date have focused on ribosomal RNA, the detection of 13C-labelled mRNA has rarely been demonstrated. This approach could alleviate some major caveats current non-target environmental 'omics. Here, we demonstrate feasibility total RNA-SIP in an experiment where hydrocarbon-degrading microbes from a BTEX-contaminated aquifer were studied microcosms with toluene under microoxic conditions. From sequencing reads (~30 mio. per...
Zoogloea oleivorans, capable of using toluene as a sole source carbon and energy, was earlier found to be an active degrader under microaerobic conditions in aquifer samples. To uncover the genetic background ability degradation Z. whole-genome sequence type strain BucT revealed. Metatranscriptomic reads, originated from previous SIP study on degradation, were mapped genome. The genome (5.68 Mb) had mean G + C content 62.5%, 5005 protein coding gene sequences 80 RNA genes. Annotation...
To prevent the spread of foodborne illnesses, presence pathogens in food chain is monitored by government agencies and producers. The culture-based methods currently employed are sensitive but time- labor-intensive, leading to increasing interest exploring culture-independent diagnostic tests (CIDTs) for pathogen detection. However, few studies quantify relative sensitivity reliability these CIDTs compared current approaches. address this issue, we conducted a comparison limit detection (LOD
Abstract Background Culture-independent diagnostic tests (CIDTs) are gaining popularity as tools for detecting pathogens in food. Shotgun sequencing holds substantial promise food testing it provides abundant information on microbial communities, but the challenge is analyzing large and complex datasets with a high degree of both sensitivity specificity. Falsely classifying reads originating from can lead to unnecessary recalls or production shutdowns, while low resulting false negatives...
ABSTRACT In order to prevent the spread of foodborne illnesses, presence pathogens in food chain is monitored by government agencies and producers. The culture-based methods currently employed are sensitive but time-and labour-intensive, leading increasing interest exploring culture-independent diagnostic tests (CIDTs) for pathogen detection. However, sensitivity reliability these CIDTs relative current approaches has not been well established. To address this issue, we conducted a...
ABSTRACT We report the draft genome sequences of seven meropenem-resistant bacterial isolates from cloacae painted and musk turtles at Lake Opinicon, Canada. This study improves our understanding spread bacteria in wild.
Background Reanalysis of exome/genome data improves diagnostic yield. However, the value reanalysis clinical array comparative genomic hybridisation (aCGH) has never been investigated. Case-by-case can be challenging in busy laboratories. Methods and results We harmonised historical postnatal aCGH from ~16 000 patients tested via our laboratory over ~7 years with current guidance. This led to identification 37 009 copy number losses (CNLs) including 33 857 benign, 2173 uncertain significance...
Culture-independent diagnostic tests are gaining popularity as tools for detecting pathogens in food. Shotgun sequencing holds substantial promise food testing it provides abundant information on microbial communities, but the challenge is analyzing large and complex datasets with a high degree of both sensitivity specificity. Falsely classifying reads originating from can lead to unnecessary recalls or production shutdowns, while low resulting false negatives could preventable illness. We...
Abstract This article describes an experimental program developed to investigate the potential for using hydrocarbon‐contaminated soils as a fine aggregate replacement in concrete. Five different contaminated soil types with total petroleum hydrocarbon content of less than 1% were investigated. For each type, three concrete mixtures obtained by replacing sand (10, 20, and 40% ratio). The resulting was tested setting times, compression strength, flexural durability, teachability benzene...
Abstract Background Re-analysis of whole exome/genome data improves diagnostic yield. However, the value re-analysis clinical array comparative genomic hybridisation (aCGH) has never been investigated. Case-by-case is impractical in busy laboratories. Methods and Results We harmonised historical post-natal aCGH results from ∼16,000 patients tested via our laboratory over ∼7 years with current guidance. This led to identification 33,857 benign, 2,173 class 3, 979 pathogenic copy number losses...
DATA REPORT article Front. Cell. Neurosci., 14 April 2021 | https://doi.org/10.3389/fncel.2021.660732