A5016630898- Connexins and lens biology
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroscience of respiration and sleep
- Heat shock proteins research
- Yersinia bacterium, plague, ectoparasites research
- Nicotinic Acetylcholine Receptors Study
- Biochemical effects in animals
- Redox biology and oxidative stress
Universidad del Desarrollo
2019-2025
Clínica Alemana
2019-2025
Oncogenes drive cancer progression, but few are active exclusively in tumor cells. Connexins (Cxs), traditionally recognized as ion channel proteins, can localize to the nucleus and regulate gene expression, playing key roles both physiological pathological processes. Cx46, once thought be restricted eye lens, has been implicated growth, though its underlying mechanisms remain unclear. This study investigates nuclear presence of Cx46 cells potential role a transcriptional modulator. We...
Background: Extravillous trophoblasts (EVTs) form stratified columns at the placenta–uterus interface. In closest part to fetal structures, EVTs have a proliferative phenotype, whereas in maternal they present migratory phenotype. During placentation process, Connexin 40 (Cx40) participates both proliferation and migration of EVTs, which occurs under hypoxia. However, possible interaction between hypoxia Cx40 has not yet been established. Methods: We developed two cellular models, one with...
Abstract Connexins (Cxs) have the ability to form channels that allow exchange of ions/metabolites between adjacent cells (gap junction channels, GJC) or intra- and extra-cellular compartments (hemichannels, HC). Cxs were initially classified as tumor suppressors. However, more recently, it has been shown exert anti- pro-tumorigenic effects depending on cell tissue context. In prostate cancer (PCa), expression functionality remain highly controversial. Here, we analyzed pattern Cx26, Cx32,...