A5065901976- Gut microbiota and health
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 detection and testing
- Berberine and alkaloids research
- Cancer Research and Treatments
- Metabolism, Diabetes, and Cancer
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Health and Risk Factors
- Inflammatory Bowel Disease
- Histone Deacetylase Inhibitors Research
- Biosensors and Analytical Detection
- CAR-T cell therapy research
- Ginseng Biological Effects and Applications
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Oral microbiology and periodontitis research
- Blood Pressure and Hypertension Studies
- Ubiquitin and proteasome pathways
- Diabetic Foot Ulcer Assessment and Management
- Probiotics and Fermented Foods
Chengdu University of Traditional Chinese Medicine
2015-2025
The relationship between gut microbiota and metabolites play an important role in the occurrence development of type 2 diabetes mellitus (T2DM). However, interaction intestinal flora abundance is still unclear. purpose this study was to investigate correlation network fecal regulating T2DM.This a case-control study. T2DM patients with different glucose levels healthy people were divided into case group normal controls (NC) group. Fasting plasma samples collected from subjects....
To investigate the correlation between gut microbiota and circulating microRNAs (miRNAs) in patients with primary diagnosis of type 2 diabetes mellitus (T2DM) to explore possible mechanisms miRNA-gut crosstalke network regulation insulin signaling pathway glucose homeostasis T2DM.T2DM normal controls were recruited. Fasting plasma fecal samples collected from subjects, their biochemical indexes including fasting blood (FBG), glycated hemoglobin (HbAlc), cholesterol (TC), total triglycerides...
An imbalance in energy metabolism serves as a causal factor for type 2 diabetes (T2D). Although metformin has been known to ameliorate the overall imbalance, but direct correlation between and central carbon (CCM) not thoroughly investigated. In this study, we employed high-performance ion chromatography-tandem mass spectrometry (HPIC-MS/MS) technique examine alterations significance of CCM both before after treatment T2D.
Insufficient insulin secretion or inefficient response are responsible for the clinical outcome of type 2 diabetes mellitus. Administration alone is prone to cause secondary effects, resulting in an unsatisfactory outcome. Shen-Qi-Formula (SQF), a well-known Chinese medicinal formula, has been used diabetic treatment long time. The present study was designed investigate whether SQF combination with improved mellitus, and what mechanisms were possibly involved treatment.A total 219 patients...
Programmed cell death 1 ligand (PD-L1) and its receptor (PD-1) are key molecules for immunoregulation immunotherapy. PD-L1 binding PD-1 is an effective way to regulate T or B immunity in autoimmune diseases such as rheumatoid arthritis (RA). In our study, we overexpressed by constructing a recombinant of PD-L1-lentiviral vector, which was subsequently used transfect mouse bone marrow mesenchymal stem cells (MBMMSCs) significantly suppressed the development collagen-induced (CIA) DBA/1j mice....
Intestinal flora and its metabolites are closely related to the progression of type 2 diabetes mellitus(T2DM). Eubacterium is one dominant intestinal flora, short-chain fatty acids (SCFAs) play a leading role in regulating metabolic balance. It has been reported that SCFAs can regulate secretion glucagon-like peptide-1, improve function pancreatic β cells, participate bile metabolism production inflammatory factors T2DM. Based on above research background, this article mainly reviews...
Type 2 diabetes mellitus (T2DM) is a major social and public health problem which may be induced by intestinal flora imbalance through inflammatory response, the specific mechanism remains unclear. In this study, we aim to explore interaction network of cell inflammation in T2DM.This case-control study. Patients with T2DM was case group healthy people as control. The differences cytokine expression levels between patients controls were assessed using flow cytometry. diversity abundance...
Diabetic peripheral neuropathy (DPN) is one of the chronic complications diabetic neuropathy, and also main cause wounds disability. Exosomes exosomal-microRNAs (miRNAs) are closely related to DPN participate in signal transduction protein expression nervous system by mediating intercellular communication. However, specific role mechanism EVs exosomal-miRNAs occurrence development high-glucose environments not fully understood. This article reviews promotion inhibiting axon growth, promoting...
Background: The reference intervals (RIs) of adult blood lipid parameters currently used in China are not derived from the results research local populations and have been adjusted for age sex. In this study, we aimed to determine accurate RIs glucose (GluG) Chinese adults using a national multicenter study. Methods: A total 11,333 between 18 90 years were recruited seven representative regions June 2020 December 2020. Hospitals participating study regrouped into two geographical regions,...
Abstract (1) Background : Host-microbiome dysbiosis have been linked to type 2 diabetes mellitus (T2DM). The purpose of this paper is investigate whether Phascolarctobacterium and faecium (P. faecium) serve as ideal biomarkers for T2DM. On basis, evaluate the key role multi-omics analysis in early diagnosis T2DM; (2) Methods Detected Stool samples from healthy people, T2DM patients, patients after metformin treatment our cohort study by 16S rRNA gene amplicon sequencing. In addition, various...