A5100641013- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Analytical chemistry methods development
- Electrochemical sensors and biosensors
- Growth Hormone and Insulin-like Growth Factors
- Bone Tissue Engineering Materials
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Hydrogels: synthesis, properties, applications
- Cardiac Imaging and Diagnostics
- Biosimilars and Bioanalytical Methods
- Circular RNAs in diseases
- TGF-β signaling in diseases
- Graphene and Nanomaterials Applications
- COVID-19 Clinical Research Studies
- Vascular Malformations and Hemangiomas
- Sepsis Diagnosis and Treatment
- Diet and metabolism studies
- Wound Healing and Treatments
- Ear and Head Tumors
- Bariatric Surgery and Outcomes
- Parathyroid Disorders and Treatments
- Galectins and Cancer Biology
- Folate and B Vitamins Research
- Biomarkers in Disease Mechanisms
Beijing Anzhen Hospital
2009-2025
Capital Medical University
2009-2025
Zunyi Medical University
2024
Capital University
2014-2023
Xinjiang Uygur Autonomous Region Product Quality Supervision and Inspection Institute
2022
Huazhong University of Science and Technology
2022
Wuhan Children's Hospital
2022
Nanjing Medical University
2020
Xuzhou Medical College
2020
The First People’s Hospital of Lianyungang
2020
Abstract Accumulating evidence has revealed that aberrant Circular RNAs (circRNAs) expression plays important roles in carcinogenesis and tumor progression. However, their role non-small cell lung cancer (NSCLC) remains unclear. In this study, we first used circRNA microarrays to screen for tumour-specific candidates between NSCLC (n = 3) adjacent tissue. Among the profile, two circRNAs (hsa_circ_0014130 hsa_circ_0016760) were selected validation ten pairs of non-cancerous tissues by...
Abstract A new recognition method is explored for the rapid detection of B‐type natriuretic peptide (BNP) based on rational design and solid‐phase synthesis molecularly imprinted nanoparticles (nanoMIP) encapsulated with carbon dots. The nanosized magnetic template first prepared by attaching epitope BNP amino‐functionalized carriers. High‐dilution polymerization monomers in presence generates lightly crosslinked nanoparticles. To obtain optimal MIP formulation, a combinatorial screening...
Hypertension combined with hyperhomocysteinemia significantly raises the risk of ischemic stroke. Our study aimed to develop and validate a biomarker-based prediction model for stroke in Hyperhomocysteinemia-type (H-type) hypertension patients. We retrospectively included 3,305 patients development cohort, externally validated 103 from another cohort. Logistic regression, least absolute shrinkage selection operator best subset analysis were used assess contribution variables stroke, models...
Research on heart injury caused by COVID-19 is limited to large observational and retrospective cohort studies using imaging or pathological data. Reported changes in the levels of myocardial markers severe diseases have been limited, with few mild infections. The effects cardiac function marker not yet reported. We analyzed data from outpatient blood samples collected at Beijing Anzhen Hospital during 2022 outbreak used same periods 2020 2021 as controls, focusing routine tests,...
Acute coronary syndrome (ACS) includes conditions such as unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI), and ST (STEMI). High-sensitivity cardiac troponin I (hs-cTnI) assays have been recommended primary biomarkers for NSTEMI diagnosis due to their high sensitivity specificity. However, there is no consensus on the optimal diagnostic strategy early detection. This study aims evaluate performance of four hs-cTnI-based strategies suspected NSTEMI: Limit Detection (LoB),...
The prevalence of diabetes is increasing in China. Glucose control very important diabetic patients. aim this study was to compare the accuracy five glucose meters used Chinese hospitals with a reference method, absence and presence various factors that may interfere meters.Within-run precision evaluated include Roche Accu-Chek Inform®, Abbott Precision PCx FreeStyle®, Bayer Contour®, J&J LifeScan SureStep Flexx®, Nova Biomedical StatStrip®. interference hematocrit level, maltose, ascorbic...
In this study, an insulin-like growth factor-1 (IGF-1) certified reference material (CRM) was developed by the National Institute of Metrology (NIM), and two different principles for evaluating IGF-1 CRM were established. After optimisation acid hydrolysis conditions (110 °C, 36 h), quantitative determination peptide purity, chromatographic separation mass spectrometric detection, amino analysis-based high-performance liquid chromatography combined with isotope-dilution tandem spectrometry...
Objective This prospective study compared the efficacy and safety of laparoscopic gastric bypass sleeve gastrectomy in treating overweight obese patients with BMI>28 kg/m2 type-2 diabetes.Methods Patients were randomized into a group (n = 77) or 80). The surgery time, intraoperative blood loss, recovery hospitalization time collected. BMI, waistline, hipline, C-peptide level, insulin resistance index (HOMA-IR), their lipid profile also measured.Results Surgery loss significantly higher...
Background: The reference intervals (RIs) of adult blood lipid parameters currently used in China are not derived from the results research local populations and have been adjusted for age sex. In this study, we aimed to determine accurate RIs glucose (GluG) Chinese adults using a national multicenter study. Methods: A total 11,333 between 18 90 years were recruited seven representative regions June 2020 December 2020. Hospitals participating study regrouped into two geographical regions,...
Background: This study demonstrates differences in the distribution of multiple cardiovascular biomarkers between non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA) patients. Diagnostic machine learning predictive models measured at time admission 1/2 h post-admission, achieving competitive diagnostic results. Objective: aims to explore value changes high-sensitivity cardiac troponin I (hs-cTnI) levels patients with suspected NSTEMI. Methods: A total 267...
<title>Abstract</title> Hypertension combined with hyperhomocysteinemia significantly raises the risk of ischemic stroke. Our study aimed to develop and validate a biomarker-based prediction model for stroke in H-type hypertension patients. We retrospectively included 3,305 patients development cohort, externally validated 103 from another cohort. Logistic regression, LASSO best subset selection analysis were used assess contribution variables stroke, models derived using four machine...
Abstract Background We validated the performance of seven different reagents peroxidase method for sdLDL‐C in two automatic analyzers that are common Chinese laboratories. Methods Seven commercially available assays were analyzed with Beckman AU5400 and Mindray BS2000 analyzers. A total 336 blood samples collected reference interval was also 298 apparently healthy individuals. Serum used comparison precision, recovery, lower limit detection, concurrence analysis, as well reagent. Results The...
An insulin-like growth factor-1 (IGF-1) certified reference material (CRM) was developed by the National Institute of Metrology (NIM), and two different principles for evaluating IGF-1 CRM were established. After optimizing conditions acid hydrolysis, quantitative determination peptide purity, chromatographic separation mass spectrometric detection, amino analysis-based high-performance liquid chromatography combined with isotope-dilution tandem spectrometry methods (AAA-HPLC-IDMS/MS)...
Novel immunodominant antigens are urgently required for the diagnosis and vaccination of Helicobacter pylori (HP). FliD, an important colonization factor, was cloned expressed (rFliD) to evaluate levels specific immunoglobulin G (IgG), IgM, IgA antibodies in serum patients using ELISA. Rabbit anti-rFliD polyclonal antibody (pAb) obtained by subcutaneous injection rFliD. The rFliD-specific IFN-γ IL-4 peripheral blood mononuclear cells CD4+ T from humans were analyzed enzyme-linked immunospot...
Carbamate (CB) pesticides possess potential carcinogenic and mutagenic activities towards humans even at very low dosages. Thus, broad-specificity probes with high sensitivity speed are needed for multiple CB determination. This study is the first to focus on Dy3+ ions-coordinated self-assembly a silica core using surface imprinting procedure, simultaneous fluorometric detection of residues metolcarb (MC) pirimicarb (PC) insecticides. A simple mild solvothermal method was applied preparation...
Objective To establish the reference range of serum human insulin levels in our laboratory and investigate measurement stability, Methods The automated Architect i2000 chemiluminescence immunoassay, calibrator quality control materials were used to measure concentration insulin. Totally 413 cases healthy adults enrolled. physiologic characteristics influence markers on analyzed. Then was established. thermal stability at different temperatures investigated. Results Within-run imprecision...