Lucas Frungillo

ORCID: 0000-0003-0693-881X
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Plant Stress Responses and Tolerance
  • Plant responses to water stress
  • Plant nutrient uptake and metabolism
  • Photosynthetic Processes and Mechanisms
  • Phytochemical compounds biological activities
  • Mitochondrial Function and Pathology
  • Soybean genetics and cultivation
  • Traditional and Medicinal Uses of Annonaceae
  • Microbial Metabolism and Applications
  • Plant Molecular Biology Research
  • Plant Pathogenic Bacteria Studies
  • Plant-Microbe Interactions and Immunity
  • Legume Nitrogen Fixing Symbiosis
  • Synthetic Organic Chemistry Methods
  • Phytoestrogen effects and research
  • Rice Cultivation and Yield Improvement
  • Genetic Syndromes and Imprinting
  • Polysaccharides and Plant Cell Walls
  • Plant Reproductive Biology
  • RNA modifications and cancer
  • Piperaceae Chemical and Biological Studies
  • Plant Gene Expression Analysis
  • Plant Water Relations and Carbon Dynamics
  • Lipid metabolism and disorders
  • Paraoxonase enzyme and polymorphisms

University of Edinburgh
2016-2023

American Society of Plant Biologists
2022-2023

Universidade Estadual de Campinas (UNICAMP)
2009-2016

Water deficit is a major environmental constraint on crop productivity and performance nitric oxide (NO) an important signaling molecule associated with many biochemical physiological processes in plants under stressful conditions. This study aims to test the hypothesis that leaf spraying of S-nitrosoglutathione (GSNO), NO donor, improves antioxidant defense both roots leaves sugarcane water deficit, positive consequences for photosynthesis. In addition, roles key photosynthetic enzymes...

10.1111/ppl.12575 article EN Physiologia Plantarum 2017-04-18

Nitrate reductase (NR) activity is necessary for the synthesis of nitric oxide (NO), a key signaling molecule in plants. Here, we investigated effect NR deficiency on NO production and phenylpropanoid metabolism Arabidopsis thaliana leaves. HPLC–mass spectrometry analysis showed that double mutant (nia1 nia2) deficient sinapoylmalate (SM), main end-product wild-type leaves, resulting accumulation its precursor sinapoylglucose (SG). While real-time PCR revealed no significant difference at...

10.1093/pcp/pcs104 article EN Plant and Cell Physiology 2012-07-25

An atisane diterpene was isolated from Xylopia langsdorfiana St. Hilaire & Tulasne, Annonaceae, leaves, ent-atisane-7α,16α-diol (xylodiol). Preliminary study showed that xylodiol cytotoxic and induced differentiation on human leukemia cell lines. However, the molecular mechanisms of xylodiol-mediated cytotoxicity have not been fully defined. Thus, we investigated anti-tumor effect in HL60 line. Xylodiol apoptosis necrosis. cells treated with biochemical changes characteristic apoptosis,...

10.1590/s0102-695x2011005000135 article EN cc-by-nc-nd Revista Brasileira de Farmacognosia 2011-08-05

Perception of microbes by plants leads to dynamic reprogramming the transcriptome, which is essential for plant health. The appropriate amplitude this transcriptional response can be regulated at multiple levels, including chromatin. However, mechanisms underlying interplay between chromatin remodeling and transcription dynamics upon activation immunity remain poorly understood. Here, we present evidence that bacteria nucleosome repositioning, correlates with altered transcription....

10.1371/journal.ppat.1009572 article EN cc-by PLoS Pathogens 2021-05-20

Violacein is a compound obtained from Chromobacterium violaceum, bacterium found in the Amazonian region. Violacein-loaded poly (D, L-lactide-co-glycolide) nanoparticles has similar inhibitory effect evaluated by trypan blue assay on leukemic HL60 cells than free form. However, cytotoxic effects phosphatase activity and MTT reduction assays were lower for encapsulated form violacein. Based morphological changes, violacein entrapped to induce terminal differentiation (assessed nitro...

10.1166/jbn.2009.1018 article EN Journal of Biomedical Nanotechnology 2009-03-26

Two new diterpenes were isolated from stems and leaves of Xylopia langsdorffi ana, entatisane- 7α,16α-diol (xylodiol) ent-7α-acetoxytrachyloban-18-oic acid (trachylobane), along with the known 8(17),12E,14-labdatrien-18-oic (labdane). We investigated their antitumour effects on HL60, U937 K562 human leukemia cell lines. found that xylodiol was most potent diterpene in inhibiting proliferation cells, mean IC 50 values 90, 80 μM, respectively. Based nitroblue tetrazolium (NBT) reduction assay,...

10.1515/znc-2009-9-1008 article EN cc-by-nc-nd Zeitschrift für Naturforschung C 2009-10-01

10.1016/j.molcel.2017.08.001 article EN publisher-specific-oa Molecular Cell 2017-08-01

Although soybean isoflavones naturally accumulate in their conjugated forms, the beneficial effects on human health of soybean-containing foods have been credited to aglycone forms. In present study we analyzed a chemical agent, sodium nitroprusside (SNP), eliciting exudation non- from intact seeds, embrionary axes and cotyledons. The exudates were determined by high performance liquid chromatography mass spectrometry. effect emission nitric oxide (NO) proliferation breast carcinoma cells...

10.1590/s0102-695x2012005000101 article EN cc-by-nc-nd Revista Brasileira de Farmacognosia 2012-09-05

Although soybean isoflavones naturally accumulate in their conjugated forms, the beneficial effects on human health of soybean-containing foods have been credited to aglycone forms. In present study we analyzed a chemical agent, sodium nitroprusside (SNP), eliciting exudation non-conjugated from intact seeds, embrionary axes and cotyledons. The exudates were determined by high performance liquid chromatography mass spectrometry. effect emission nitric oxide (NO) proliferation breast...

10.1590/s0102-695x2013000100012 article EN cc-by-nc-nd Revista Brasileira de Farmacognosia 2013-02-01
Coming Soon ...